Discerning malignancy in adrenocortical tumors: Are molecular markers useful?

European Journal of Endocrinology

Volumn 145, Issue 3, 2001, Pages 335-341

  Wachenfeld, C ^a   Beuschlein, F ^a   Zwermann, O ^a   Mora, P ^a   Fassnacht, M ^a   Allolio, B ^a   Reincke, M ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; KI 67 ANTIGEN; METHIONINE; MONOCLONAL ANTIBODY; MUTANT PROTEIN; POLYCLONAL ANTIBODY; PROTEIN P53;

ADOLESCENT; ADRENAL CORTEX; ADRENAL CORTEX ADENOMA; ADRENAL CORTEX CARCINOMA; ADRENAL CORTEX TUMOR; ADULT; AGED; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BENIGN TUMOR; CANCER INVASION; CHROMOSOME 11Q; CHROMOSOME 17P; CLINICAL ARTICLE; CONTROLLED STUDY; CUSHING SYNDROME; DIFFERENTIAL DIAGNOSIS; DISEASE MARKER; FEMALE; GENE LOCUS; GENE MUTATION; HETEROZYGOSITY LOSS; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; METASTASIS; NICK END LABELING; PRIORITY JOURNAL; PROGNOSIS; SENSITIVITY AND SPECIFICITY; TUMOR CELL; TUMOR SUPPRESSOR GENE;

EID: 0034839753     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1450335     Document Type: Article

References (34)

1. The incidentally discovered adrenal mass
2. Clinical and pathophysiologic aspects of adrenocortical carcinoma
3. Adrenal masses: Evaluation with fast gradient-echo MR imaging and Gd-DTPA-enhanced dynamic studies
4. A survey on adrenal incidentaloma in Italy
5. Natural course of adrenal incidentalomas: Seven-year follow-up study
6. Prognostic factors in adrenal cortical tumors: A mathematical analysis of clinical and morphologic data
7. Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors
8. Pathologic features of prognostic significance in adrenocortical carcinoma
9. Morphologic characteristics of benign and malignant adrenocortical tumors
10. Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma
11. Allelic loss of the retinoblastoma tumor suppressor gene: A marker for aggressive parathyroid tumors?
12. Evaluation of retinoblastoma and Ki-67 immunostaining as diagnostic markers of benign and malignant parathyroid disease
13. Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: Study on a series of 82 tumors
14. Insulin-like growth factor receptors in normal and tumorous adult human adrenocortical glands
15. Increased levels of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 are associated with malignancy in sporadic adrenocortical tumors
16. MHC class II expression - A new tool to assess dignity in adrenocortical tumors
17. Discerning malignancy in human adrenocortical neoplasms: Utility of DNA flow cytometry and immunohistochemistry
18. Immunopathology of adrenal and renal cortical tumors. Coordinated change in antigen expression is associated with neoplastic conversion in the adrenal cortex
19. Immunohistochemical assessment of proliferative activity in adrenocortical neoplasms
20. p53 mutations in adrenal tumors: Caucasian patients do not show the exon 4 Hot Spot found in Taiwan
21. p53 mutations in sporadic adrenocortical tumors
22. Clinical and genetic features of adrenocortical lesions in multiple endocrine neoplasia type 1
23. Adrenal lesion in multiple endocrine neoplasia type 1
24. The adrenal cortex
25. Variable number of tandem repeat (VNTR) markers for human gene mapping
26. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
27. Molecular tools for presymptomatic testing in multiple endocrine neoplasia type 1
28. The role of prognostic markers (MiB-1, RB, and bcl-2) in the diagnosis of parathyroid tumors
29. MIB1 immunopositivity is associated with rapid regrowth of pituitary adenomas
30. Prognostic criteria in nonfunctioning pancreatic endocrine tumours
31. Apoptosis and proliferation in thyroid carcinoma: Correlation with bcl-2 and p53 protein expression
32. Ki67 antigen immunostaining (MIB 1 monoclonal antibody) in serous ovarian tumors: Index of proliferative activity with prognostic significance
33. Prognostic significance of immunohistochemical proliferation markers (Ki-67/MIB-1 and proliferation associated nuclear antigen), p53 accumulation, and neovascularization in clinical stage A nonseminomatous testicular germ cell tumors
34. Risk factors and long-term follow-up of adrenal incidentalomas