The relevance of murine animal models to study the development of allergic bronchial asthma

Immunology and Cell Biology

Volumn 74, Issue 2, 1996, Pages 209-217

  Herz, Udo ^a   Lumpp, Uschi ^a   Da Palma, Joao Casimiro ^a   Enssle, Karlheinz ^b   Takatsu, Kiyoshi ^c   Schnoy, Norbert ^a   Daser, Angelika ^a   Köttgen, Eckart ^a   Wahn, Ulrich ^a   Renz, Harald ^a,d  

^a HUMBOLDT UNIVERSITY   (Germany)

^b Behringwerke AG   (Germany)

^c UNIVERSITY OF TOKYO   (Japan)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Airway hyperresponsiveness; Allergic inflammation; Bronchial asthma; Hu SCID mouse; IgE; Murine animal model; SIL 4R

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5;

ANIMAL MODEL; ARTICLE; ASTHMA; COMBINED IMMUNODEFICIENCY; EOSINOPHIL; MOUSE; NONHUMAN; T LYMPHOCYTE;

EID: 9344226742     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1038/icb.1996.30     Document Type: Article

References (61)

1. Burrows B, Martinez FD, Halonen M, Barbec RA. Cline MG. Association of asthma with scrum IgE levels and skin-test reactivity to allergens. N. Engl. J. Med. 1989; 320: 271-7.
2. Sears MR, Burrows B, Flannery EM, Herbison GP. Hewitt CJ, Holdaway MD. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N. Engl. J. Med. 1991; 326: 1067-71.
3. +) T cells and eosinophils in allergy and asthma. Am. Rev. Respir. Dis. 1992; 145: S22-6.
4. Robinson DS, Hamid Q, Ying S et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 1992; 326: 298-303.
5. De Sanctis G, Merchant M, Beier DR et al. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nature Genet. 1995; 11: 150-4.
6. Levitt RC, Eleff SM, Zhang L-Y, Kleeberger SR, Ewart SL. Linkage homology for bronchial hyperresponsiveness between DNA markers on human chromosome 5q31-q33 and mouse chromosome 13. Clin. Exp. Allergy 1995; 25: 61-3.
7. Marsh DG, Hsu SH, Roebber M et al. HLA-Dw2: A genetic marker for human immune response to short ragweed pollen allergen Ra5. J. Exp. Med. 1982; 155: 1439-51.
8. Ansari AA, Freidhoff LR, Meyers DA, Bias WB, Marsh DG. Human immune responsiveness to Lolium perenne pollen allergen Lol p III (rye III) is associated with HLA-DR3 and DR5. Hum. Immunol. 1989; 25: 59-71.
9. Ansari AA, Shinomiya N, Zwollo P, Marsh DG. HLA-D gene studies in relation to immune responsiveness to grass pollen allergen. Lol p III. Immunogenetics 1991; 33: 24-32.
10. Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CIM. Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with major gene for atopy. N. Engl. J. Med. 1995; 333: 894-900.
11. Van Herwerden L, Harrap SB, Wong ZYH et al. Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy. Lancet 1995; 346: 1262-5.
12. Azzawi M, Bradley B, Jeffery PK et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am. Rev. Respir. Dis. 1990; 142: 1407-13.
13. Walker C, Virchow JC, Bruijnzeel PLB, Blaser K.T cell subsets and their soluble products regulate cosinophilia in allergic and non-allergic asthma. J. Immunol. 1991; 146: 1829-35.
14. Bentley AM, Meng Q, Robinson DS, Hamid Q, Kay AB, Durham SR. Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics. Am. J. Respir. Cell Mol. Biol. 1993; 8: 35-42.
15. Yousefi S, Green DR, Blaser K, Simon HU. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc. Natl. Acad. Sci. USA 1994, 91: 10 868-72.
16. Roche WR, Beasley R, Williams JH, Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989; 1: 520-4.
17. Brewster CE, Howarth PH, Djukanovic R, Wilson J, Holgate ST, Roche WR. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 1990; 3: 507-11.
18. Springall DR, Howarth PH, Counihan H, Djukanovic R, Holgate ST, Polak JM. Endothelin immunoreactivity of airway epithelium in asthmatics patients. Lancet 1991; 337: 697-701.
19. Holt PG, Rose AH, Batty JE, Turner KJ. Induction of adjuvant-independent IgE responses in inbred mice. Primary, secondary, and persistent IgE responses to ovalbumin and ovomucoid. Int. Archs. Allergy Appl. Immun. 1981; 65: 42-50.
20. Renz H, Smith HR, Henson JE, Ray BS, Irvin CG, Gelfand EW. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J. All. Clin. Immunol. 1992; 89: 1127-38.
21. Lau S, Falkenhorst G, Weber A, Werthmann I, Lind P, Wahn U. High mite allergen exposure increases the risk of sensitization in atopic children. J. Allergy Clin. Immunol. 1989; 84: 718-25.
22. Stewart GA, Holt PG. Immunogenicity and tolerogenicity of a major house dust mite allergen. Der p I from Dermatophagoides pteronyssinus, in mice and rats. Int. Archs. Allergy Appl. Immun. 1987; 83: 44-51.
23. Nakano Y, Yoshida M, Shibata T. Strong delayed-type hypersensitivity induced against house dust mite antigens in the mice. Int. Arch. Allergy Appl. Immunol. 1989; 88: 434-8.
24. Hoyne GF, O'Hehir RE, Wraith DC, Thomas WR, Lamb JR. Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J. Exp. Med. 1993, 178: 1783-8.
25. Renz H, Bradley KL, Marrack P, Gelfand EW. T cells expressing variable elements of T-cell receptor β8 and β2 chain regulate murine IgE production. Proc. Natl Acad. Sci. USA 1992; 89: 6438-42.
26. Renz H, Bradley K, Saloga J, Loader J, Larsen GL, Gelfand EW. T cells expressiong specific Vβ elements regulate immunoglobulin E production and airways responsiveness in vitro. J. Exp. Med. 1993; 177: 1175-80.
27. Renz H, Lack G, Saloga J et al. Inhibition of IgE production and normalization of airways responsiveness by sensitized CD8 T cells in a mouse model of allergen-induced sensitization. J. Immunol. 1994; 152: 351-60.
28. Watanabe A, Mishima H, Renzi PM, Xu L-J, Hamid Q, Martin JG. Transfer of allergic airway responses with antigen-primed CD4+ but not with CD8+ T cells in Brown Norway rats. J. Clin. Invest. 1995; 96: 1303-10.
29. Watanabe A, Rossi P, Renzi PM, Xu L-J, Guttmann RD, Martin JG. Adoptive transfer of allergic airway responses with sensitized lymphocytes in BN rats. Am. J. Respir. Crit. Care Med. 1995; 152: 64-70.
30. Noble A, Macary PA, Kemeny DM. IFN-γ and IL-4 regulate the growth and differentiation of CD8+ T cells into sub-populations with distinct cytokine profiles. J. Immunol. 1995; 155: 2928-37.
31. Bluestone JA. New perspectives of CD28-B7-mediatcd T cell costimulation. Immunity 1995; 2: 555-9.
32. Zhang K, Clark EA, Saxon A. CD40 stimulation provides and IFN-gamma-independent and IL-4 dependent differentiation signal directly to human B cells for IgE production. J. Immunol. 1991; 146: 1836-42.
33. Finkelman FD, Holmes J. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 1990; 8: 303-33.
34. Kühn R, Rajewski K, Müller W. Generation and analysis of IL-4 deficient mice. Science 1991; 254: 707-10.
35. Suematsu S, Matsuda T, Aozasa K et al. IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc. Natl Acad. Sci. USA 1989; 86: 7547-51.
36. Zurawski G, de Vries JE. Interleukin 13, an interleukin 4-like cytokinc that acts on monocytes and B cells, but not on T cells. Immunol. Today 1994; 15: 19-26.
37. McMenamin C, Pimm C, McKersey M, Holt PG. Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells. Science 1994; 265: 1869-71.
38. Saloga J, Renz H, Lack G, Bradley KL, Larsen G, Gelfand EW. Development and transfer of immediate cutaneous hypersensitivity in mice exposed to aerosolized antigen. J. Clin. Invest. 1993; 91: 133-40.
39. Takizawa F, Adamezewski M, Kinet J-P. Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fcγ-RII and Fcγ-RIII. J. Exp. Med. 1992; 176: 469-76.
40. Garssen J, Nijkamp FP, van der Vliet H, van Loveren H. T-cell-mediated induction of airway hyperreactivity in mice. Am. Rev. Respir. Dis. 1991; 144: 931-8.
41. Larsen GL, Renz H, Loader JE, Bradley KL, Gelfand EW. Airway response to electrical field stimulation in sensitized inbred mice: passive transfer of increased responsiveness with peribronchial lymph nodes. J. Clin. Invest. 1992; 89: 747-52.
42. 2 into human airways during acute antigen challenge. N. Engl. J. Med. 1986; 315: 800-4.
43. Virchow J-C, Walker C, Hafner D et al. T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am. J. Respir. Crit. Care Med. 1995; 151: 960-8.
44. Larsen GL, Fame TM, Renz H et al.Increased acetylcholine release in tracheas from allergen-exposed IgE-immune mice. Am. J. Physiol. 1994; 266: L263-70.
45. Maliszewski CR, Sato TA, Vanden Bos S et al. Cytokine receptors and B cell function. 1. Recombinant soluble receptors specifically inhibit IL-I and IL-4 induced B cell activities in vitro. J. Immunol. 1990; 144: 3028-33.
46. Garrone P, Djossou O, Galizzi J-P, Banchereau J. A recombinant extracellular domain of the human interleukin-4 receptor inhibits the biological effects of interleukin-4 on T and B lymphocytes. Eur. J. Immunol. 1991; 21: 1365-9.
47. Sato TA, Widmer MB, Finkelman FD et al. Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo. J. Immunol. 1993; 150: 2717-23.
48. Nasert S, Millner M, Herz U et al. Therapeutic interference with interferon-γ (IFN-γ) and soluble IL-4 receptor (sIL-4R) in allergic diseases. Behring Inst. Mitt. 1995; 96: 118-30.
49. Finkelman FD, Katona IM, Urban JF, Snapper CM, Ohara J, Paul WE. Suppression of in vivo polyclonal IgE responses by mononuclear antibody to the lymphokine BSF-1. Proc. Natl Acad. Sci. USA 1986; 83: 9675-8.
50. Kennedy JD, Hatfield CA, Fidler SF et al. Phenotypic characterization of T lymphocytes emigration into lung tissue and the airway lumen after antigen inhalation in sensitized mice. Am. J. Respir. Cell Mol. Biol. 1995; 12: 613-23.
51. Van Oosterhout AJM, Fattah D, van Ark I, Hofman G, Buckley TL, Nijkamp FP. Eosinophil infiltration precedes development of airway hyperreactivity and mucosal exudation after intranasal administration of interleukin-5 to mice. J. Allergy Clin. Immunol. 1995; 96: 104-12.
52. Van Oosterhout AJM, Ladenius ARC, Savelkoul HFJ, Van Ark I, Delsman KC, Nijkamp FP. Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs. Am. Rev. Respir. Dis. 1993; 147: 548-52.
53. Nagai H, Yamaguchi S, Inagaki N, Tsuruoka N, Hitoshi Y, Takatsu K. Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in mice. Life Sciences 1993; 53: 243-7.
54. Yamaguchi S, Nagai H, Tanaka H, Tsujimoto M, Tsuruoka N. Time course study for antigen-induced airway hyperreactivity and the effect of soluble IL-5 receptor. Life Science 1994; 54: 471-5.
55. Mauser PJ, Pitman AM, Fernandez X et al. Effects of an antibody to interleukin-5 in a monkey model of asthma. Am. J. Respir. Crit. Care Med. 1995; 152: 467-72.
56. Kung TT, Stelts DM, Zurcher JA et al. Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody. Am. J. Respir. Cell Mol. Biol. 1995, 13: 360-5.
57. Gavett SH, Chen X, Finkelman F, Wills-Karp M. Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am. J. Respir. Cell Mol. Biol. 1994, 10: 587-93.
58. Coyle AJ, Le Gros G, Bertrand C et al. Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am. J. Respir. Cell Mol. Biol. 1995; 13: 54-59.
59. Brusselle G, Kips J, Joos G, Bluethmann H, Pauwels R. Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am. J. Respir. Cell Mol. Biol. 1995; 12: 254-9.
60. + T-lymphocytes and interleukin-5 mediate antigen-induced cosinophil infiltration into the mouse trachea. Am. Rev. Respir. Dis. 1992; 146: 374-7.
61. Kung TT, Jones H, Adamm III GK et al. Characterization of a murine model of allergic pulmonary inflammation. Im. Arch. Allergy Immunol. 1994, 105: 83-90.