Human T cells that have been conditioned by the proteolytic activity of the major dust mite allergen Der p 1 trigger enhanced immunoglobulin E synthesis by B cells

Clinical and Experimental Allergy

Volumn 32, Issue 5, 2002, Pages 728-732

  Ghaemmaghami, A M ^a   Shakib, F ^a,b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

B cell; Der p 1; IFN ; IgE; IL 4; T cell

Indexed keywords

HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; DERMATOPHAGOIDES PTERONYSSINUS ANTIGEN P 1; HLA D ANTIGEN;

ARTICLE; B LYMPHOCYTE; CELL ACTIVITY; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATOPHAGOIDES PTERONYSSINUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; T LYMPHOCYTE; BIOSYNTHESIS; DRUG EFFECT; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; TH2 CELL;

ANTIGENS, DERMATOPHAGOIDES; B-LYMPHOCYTES; COCULTURE; HLA-D ANTIGENS; HUMAN; IMMUNOGLOBULIN E; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TH2 CELLS; COCULTURE TECHNIQUES; HUMANS;

EID: 0035999857     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2002.01374.x     Document Type: Article

References (15)

1. The human IgE network
2. Proteolytic cleavage of CD25, the α subunit of the human T cell interleukin 2 receptor, by Der p 1: A major mite allergen with cysteine protease activity
3. Human T cell subset commitment determined by the intrinsic property of antigen: The proteolytic activity of the major mite allergen Der p 1 conditions T cells to produce more IL-4 and less IFN-γ
4. Functional diversity of helper T lymphocytes
5. The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response
6. A sensitive fluorescent assay for measuring the cysteine protease activity of Der p 1, a major allergen from the dust mite Dermatophagoides pteronyssinus
7. Potentiation of in vitro synthesis of human IgE by Cyclosporin A (CsA)
8. Peripheral blood based T cell-containing and T cell-depleted culture systems for human IgE synthesis: The role of T cells
9. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies
10. Determination of antigen-specific memory effector CD4+ T cell frequency by flow cytometry
11. Expression and kinetics of cytokines determined by intracellular staining using flow cytometry
12. Induction and regulation of the IgE response
13. Function of CD40 on B cells, dendritic cells and other cells
14. Environmental and bronchoalveolar lavage Dermatophagoides pteronyssinus antigen levels in atopic asthmatics
15. Functional effects of the inhibition of the cysteine protease activity of the major house dust mite allergen Der p 1 by a novel peptide based inhibitor