Mechanism of Janus kinase 3-catalyzed phosphorylation of a Janus kinase 1 activation loop peptide

Archives of Biochemistry and Biophysics

Volumn 410, Issue 1, 2003, Pages 7-15

  Wang, Ruixiu ^a   Griffin, Patrick R ^b   Small, Eliza C ^c   Thompson, James E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Carta Pharmaceuticals   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

JAK1; JAK3; Peptide phosphorylation; Protein tyrosine kinase

Indexed keywords

ALANINE; AMINO ACID DERIVATIVE; INTERLEUKIN 2; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; LYSYLALANYLISOLEUCYLGLUTAMYLTHREONYLASPARTYLLYSYLGLUTAMYLTYROSYLTYROSYLTHRE ONYLVALYLLYSYLASPARTIC ACID; LYSYLGLUTAMYLTYROSYLTYROSYLTHREONYLVALINE; METHYL GROUP; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CATALYST; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE LIBRARY; HYDROPHOBICITY; IMMOBILIZATION; IN VITRO STUDY; KINETICS; MASS SPECTROMETRY; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; CATALYSIS; ENZYME ACTIVATION; JANUS KINASE 1; JANUS KINASE 3; KINETICS; MASS SPECTROMETRY; MODELS, CHEMICAL; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECOMBINANT PROTEINS; TYROSINE;

JANUS;

EID: 0037325613     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9861(02)00637-9     Document Type: Article

References (23)

1. O'Shea J.J., Gadina M., Schreiber R.D. Cell. 109S:2002;121-131.
2. Duhe R.J., Farrar W.L. J. Interferon Cytokine Res. 18:1998;1-15.
3. O'Shea J.J. Immunity. 7:1997;1-11.
4. Pelligrini S., Dusanter-Fourt I. Eur. J. Biochem. 248:1997;615-633.
5. Baird A.M., Thomas D.C., Berg L.J. J. Leukocyte Biol. 63:1998;669-677.
6. Russell S.M., Taybedi N., Makajima H., Riedy M.C., Roberts J.L., Aman M.J., Migone T.-S., Noguchi M., Markert M.L., Buckley R.H., O'Shea J.J., Leonard W.J. Science. 270:1995;797-800.
7. Brugnoni D., Notarangelo L.D., Sottini A., Airo P., Pennacchio M., Mazzolari E., Signorini S., Candotti F., Villa A., Mella P., Vazzoni P., Cattaneo R., Ugazio A.G., Imberti L. Blood. 91:1998;949-955.
8. Rodig S.J., Meraz M.A., White J.M., Lampe P.A., Riley J.K., Arthur C.D., King K.L., Sheehan K.C., Yin L., Pennica D., Johnson E.M., Schreiber R.D. Cell. 93:1998;373-383.
9. Lin J.-L., Leonard W.J. Cytokine Growth Factor Rev. 8:1997;313-332.
10. Hubbard S., Mohammadi M., Schlessinger J. J. Biol. Chem. 273:1998;11987-11990.
11. Zhou Y.-J., Hanson E.P., Chen Y.-Q., Magnuson K., Chen M., Swann P.G., Wang R.L., Changelian P.S., O'Shea J.J. Proc. Natl. Acad. Sci. USA. 94:1997;13850-13855.
12. Liu K.D., Gaffen S.L., Goldsmith M.A., Greene W.C. Curr. Biol. 7:1997;817-826.
13. Segel I.H. Enzyme Kinetics. 1975;Wiley, New York.
14. Burbaum J.J., Raines R.T., Albery W.J., Knowles J.R. Biochemistry. 28:1989;9293-9305.
15. Fersht A. Enzyme Structure and Mechanism. 1977;Freeman, New York.
16. Ast T., Heine N., Germeroth L., Schneider-Mergener J., Wenschuh H. Tetrahedron Lett. 40:1999;4317-4318.
17. Kramer A., Reineke U., Dong L., Hoffmann B., Hoffmuller U., Winkler D., Volkmer-Engert R., Schneider-Mergener J. J. Peptide Res. 54:1999;319-357.
18. Krebs D., Hilton D. Stem Cells. 19:2001;378-387.
19. Yasukawa H., Misawa H., Sakamoto H., Masuhara M., Sasaki A., Wakioka T., Ohtsuka S., Imaizumi T., Matsuda T., Ihle J., Yoshimura A. EMBO J. 18:1999;1309-1320.
20. Ferrell J., Bhatt R. J. Biol. Chem. 272:1997;19008-19016.
21. Boerner R.J., Barker S.C., Knight W.B. Biochemistry. 34:1995;16419-16423.
22. Bradshaw J., Waksman G. Biochemistry. 38:1999;5147-5154.
23. Feng J., Witthuhn B.A., Matsuda T., Kohlhuber F., Kerr I.M., Ihle J.N. Mol. Cell. Biol. 17:1997;2497-2501.