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0037071880
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Spinal axon regeneration induced by elevation of cyclic AMP
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This study shows that after a peripheral conditioning lesion, cAMP levels in DRG cell bodies transiently increase. The authors also show that direct injection of db-cAMP into the DRG cell body without a conditioning lesion is sufficient to induce regeneration of subsequently lesioned dorsal column axons. This regeneration is of a similar extent to that seen with a conditioning lesion and provides further evidence of the importance of intracellular cAMP levels in the induction of regeneration following injury.
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Qiu J., Cai D., Dai H., McAtee M., Hoffman P.N., Bregman B.S., Filbin M.T. Spinal axon regeneration induced by elevation of cyclic AMP. Neuron. 34:2002;895-903 This study shows that after a peripheral conditioning lesion, cAMP levels in DRG cell bodies transiently increase. The authors also show that direct injection of db-cAMP into the DRG cell body without a conditioning lesion is sufficient to induce regeneration of subsequently lesioned dorsal column axons. This regeneration is of a similar extent to that seen with a conditioning lesion and provides further evidence of the importance of intracellular cAMP levels in the induction of regeneration following injury.
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(2002)
Neuron
, vol.34
, pp. 895-903
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Qiu, J.1
Cai, D.2
Dai, H.3
McAtee, M.4
Hoffman, P.N.5
Bregman, B.S.6
Filbin, M.T.7
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41
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0037104645
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Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro
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The authors describe a downstream consequence of elevated cAMP, which allows axons to grow on a myelin substrate. The enzyme Arginase I (ArgI), which is key in the synthesis of polyamines, is up-regulated by cAMP. Polyamines are also elevated in response to treatment with db-cAMP. Either overexpression of ArgI or addition of polyamines is sufficient to overcome inhibition by myelin. These findings illustrate yet another downstream, therapeutic target for encouraging axonal regeneration after injury.
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Cai D., Deng K., Mellado W., Lee J., Ratan R.R., Filbin M.T. Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro. Neuron. 35:2002;711-719 The authors describe a downstream consequence of elevated cAMP, which allows axons to grow on a myelin substrate. The enzyme Arginase I (ArgI), which is key in the synthesis of polyamines, is up-regulated by cAMP. Polyamines are also elevated in response to treatment with db-cAMP. Either overexpression of ArgI or addition of polyamines is sufficient to overcome inhibition by myelin. These findings illustrate yet another downstream, therapeutic target for encouraging axonal regeneration after injury.
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(2002)
Neuron
, vol.35
, pp. 711-719
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Cai, D.1
Deng, K.2
Mellado, W.3
Lee, J.4
Ratan, R.R.5
Filbin, M.T.6
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