Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site

Journal of Cell Biology

Volumn 138, Issue 6, 1997, Pages 1355-1366

  Tang, Song ^a   Shen, Ying Jing ^a   DeBellard, Maria Elena ^a   Mukhopadhyay, Gitali ^a   Salzer, James L ^b   Crocker, Paul R ^c   Filbin, Marie T ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; MYELIN ASSOCIATED GLYCOPROTEIN; SIALIC ACID;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; CONTROLLED STUDY; GROWTH INHIBITION; GROWTH REGULATION; MUTATION; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; BINDING SITES; CELL ADHESION; CHO CELLS; CRICETINAE; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MYELIN-ASSOCIATED GLYCOPROTEIN; N-ACETYLNEURAMINIC ACID; NEURITES; NEURONS; PROTEIN STRUCTURE, TERTIARY; SCHWANN CELLS; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 14444268726     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.138.6.1355     Document Type: Article

References (44)

1. Asa, D., L. Raycroft, L. Ma, P.A. Aeed, P.S. Kaytes, A.P. Elhammer, and J.G. Geng. 1995. The P-selectin glycoprotein ligand functions as a common human leukocyte ligand for P- and E-selectins. J. Biol. Chem. 270:11662-11670.
2. Bartsch L., C.E. Bandtlow, L. Schnell, S. Bartsch, A.A. Spillmann, B.P. Rubin, R. Hillenbrand, D. Montag, M.E. Schwab, and M. Schachner. 1995. Lack of evidence that the myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS. Neuron. 15:1375-1381.
3. Bregman, B.S., E. Kunke-Bagden, L. Schnell, H.N. Dal, D. Gao, and M.E. Schwab. 1995. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature (Lond.). 378:498-501.
4. Brown, M.C., V.H. Perry, E.R. Lunn, S. Gordon, and R. Heumann. 1991. Macrophage dependence of peripheral sensory nerve regeneration: possible involvement of nerve growth. Neuron. 6:359-370.
5. Brown, M.C., E.R. Lunn, and V.H. Perry. 1992. Consequences of slow Wallerian degeneration for regenerating motor and sensory axons. J. Neurobiol. 23:521-536.
6. Caroni, P., and M.E. Schwab. 1988a. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron. 1:85-96.
7. Caroni, P., and M.E. Schwab. 1988b. Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading. J. Cell Biol. 106:1281-1288.
8. Crocker, P.R., S. Mucklow, V. Bouckson, A. McWilliam, A.C. Willis, S. Gordon, G. Milon, S. Kelm, and P. Bradfield. 1994. Sialoadhesin, a macrophage sialic acid binding receptor for haemopoieic cells with 17 immunoglobulin-like domains. EMBO (Eur. Mol. Biol. Organ.) J. 13:4490-4503.
9. DeBellard, M.E., S. Tang, G. Mukhopadhyay, Y. Shen, and M.T. Filbin. 1996a. Myelin-associated glycoprotein inhibits axonal regeneration from a variety of neurons via interaction with a sialoglycoprotein. Mol. Cell. Neurosci. 7: 89-101.
10. DeBellard, M.E., T. Tang, J. Roder, and M.T. Filbin. 1996b. Inhibition of axonal regeneration by myelin involves a neuronal sialoglycoprotein. Soc. Neurosci. Abs. 130:5.
11. Doherty, P., M. Fruns, P. Seaton, G. Dickson, C.H. Barton, T.A. Sears, and F.A. Walsh. 1990. A threshold effect of the major isoforms of N CAM on neurite outgrowth. Nature (Lond.). 343:464-466.
12. Doherty, P., E. Williams, and F.S. Walsh. 1995. A soluble chimeric form of the L1 glycoprotein stimulates neurite outgrowth. Neuron. 14:57-66.
13. Fawcett, J.W., and R.J. Keynes. 1990. Peripheral nerve regeneration. Annu. Rev. Neurosci. 13:43-60.
14. Filbin, M.T. 1995. Myelin-associated glycoprotein: a role in myelination and in the inhibition of axonal regeneration? Curr. Opin. Neurobiol. 5:588-595.
15. Filbin, M.T. 1996. The muddle with MAG. Mol. Cell. Neurosci. 8:84-92.
16. Johnson, A.R. 1993. Contact inhibition in the failure of mammalian CNS axonal regeneration. Bioessays. 15:807-813.
17. Johnson, P.W., W. Abramow-Newerly, B. Seilheimer, R. Sadoul, M.B. Tropak, M. Arquint, R.J. Dunn, M. Schachner, and J.C. Roder. 1989. Recombinant myelin associated glycoprotein confers neural adhesion and neurite outgrowth function. Neuron. 3:377-385.
18. Kelm S., A. Pelz, R. Schauer, M.T. Filbin, S. Tang, M.-E. de Bellard, R.L. Schnaar, J.A. Mahoney, A. Hartnell, P. Bradfield, and P.R. Crocker. 1994. Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily. Curr. Biol. 4:965-972.
19. Keynes, R.J., and G.M.W. Cook. 1995. Repulsive and inhibitory signals. Curr. Opin. Neurobiol. 5:75-82.
20. Li, C., M.B. Tropak, R. Gerlai, S. Clapoff, W. Abramow-Newerly, B. Trapp, A. Peterson, and J. Roder. 1994. Myelination in the absence of myelin-associated glycoprotein. Nature (Lond.). 369:747-750.
21. Li, M., A. Shibata, C. Li, P.E. Braun, L. McKerracher, J. Roder, S.B. Kater, and S. David. 1996. Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse. J. Neurosci. Res. 46:404-414.
22. McKerracher L., S. David, D.L. Jackson, V. Kottis, R.J. Dunn, and P.E. Braun. 1994. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite outgrowth. Neuron. 13:805-811.
23. Montag, D., K.P. Giese, U. Bartsch, R. Martini, Y. Lang, H. Bluthmann, J. Karthigasan, D.A. Kirschner, E.S. Wintergerst, K.A. Nave, et al. 1994. Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron. 13:229-246.
24. Mukhopadhyay G., P. Doherty, F.S. Walsh, P.R. Crocker, and M.T. Filbin. 1994. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron. 13:757-767.
25. Ng, W.P., N. Cartel, C. Li, J. Roder, and A. Lozano. 1996. Myelin from MAG-deficient mice is a strong inhibitor of neurite outgrowth. Neuroreport. 7:861-864.
26. Owens, G.C., C.J. Boyd, R.P. Bunge, and J.L. Salzer. 1990. Expression of recombinant myelin-associated glycoprotein in primary Schwann cells promotes the initial investment of axons by Schwann cells. J. Cell Biol. 111: 1171-1182.
27. Pedraza, L., G.C. Owens, L.A. Green, and J.L. Salzer. 1990. The myelin-associated glycoproteins: membrane diposition, evidence for a novel disulfide linkage between immunoglobulin-like domains, and posttranslational palmitylation. J. Cell Biol. 111:2651-2661.
28. Poltorak, M., R. Sadoul, G. Keilhauer, C. Landa, T. Fahrig, and M. Schachner. 1987. Myelin-associated glycoprotein, a member of the L2/HNK-1 family of neural cell adhesion molecules, is involved in neuron-oligodendrocyte and oligodendrocyte interaction. J. Cell Biol. 105:1897-1899.
29. Porter, S.L., L. Glaser, and R.P. Bunge. 1987. Release of autocrine growth factor by primary and immortalized Schwann cell. Proc. Natl. Acad. Sci. USA. 83:7768-7771.
30. Pouyani, T., and B. Seed. 1995. PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus. Cell. 83: 333-343.
31. Ruoslahti, E., and M.D. Pierschbacher. 1987. New perspectives in cell adhesion: RGD and integrins. Science (Wash. DC). 238:491-497.
32. Sadoul, R., T. Fahring, U. Bartig, and M. Schachner. 1990. Binding properties of liposomes containing the myelin-associated glycoprotein MAG to neural cell cultures. J. Neurosci. Res. 25:1-13.
33. Sako, D., K.M. Comess, K.M. Barone, R.T. Camphausen, D.A. Cumming, and G.D. Shaw. 1995. A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding. Cell. 83:323-332.
34. Schafer, M., M. Fruttiger, D. Montag, M. Schachner, and R. Martini. 1996. Disruption of the gene for the myelin-associated glycoprotein improves axonal regrowth in C57BL/Wld mice. Neuron. 16:1107-1113.
35. Schnell, L., and M.E. Schwab. 1990. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature (Lond.). 343:269-272.
36. Schwab, M.E., J.P. Kapfhammer, and C.E. Bandtlow. 1993. Inhibitors of neurite growth. Annu. Rev. Neurosci. 16:565-596.
37. Shen, Y., F.S. Walsh, and M.T. Filbin. 1996. MAG expressed by Schwann cells inhibits axonal growth and branching. Soc. Neursci. Abstr. 130:6.
38. Simmons, D.L. 1993. Cloning cell surface molecules by transient expression in mammalian cells. In Cellular Interactions in Development - a Practical Approach. D.A. Hartley, IRL Press, Oxford. 93-128.
39. Tang, S., R.W. Woodhall, Y.J. Shen, M.E. DeBellard, J.L. Saffell, P. Doherty, F.S. Walsh, and M.T. Filbin. 1997. Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration. Mol. Cell. Neurosci. In press.
40. van der Merwe, A., P.R. Crocker, M. Vinson, A.N. Barclay, R. Schauer, and S. Kelm. 1996. Localization of the putative sialic acid-binding site on the immunoglobulin superfamily cell-surface molecule CD22. J. Biol. Chem. 271: 9273-9280.
41. Varki, A. 1994. Selectin ligands. Proc. Natl. Acad. Sci. USA. 91:7390-7397.
42. Varki, A., and J. Marth. 1995. Oligosaccharides in vertebrate development. Semin. Dev. Biol. 6:27-36.
43. Vinson, M., A. van der Merwe, S. Kelm, A. May, E.Y. Jones, and P.R. Crocker. 1996. Characterization of the sialic acid binding site in sialoadhesin by site-directed mutagenesis. J. Biol. Chem. 271:9267-9280.
44. Yang, L.J., C.B. Zeller, N.L. Shaper, M. Kiso, A. Hasegawa, R.E. Shapiro, and R.L. Schnaar. 1996. Gangliosides are neuronal ligands for myclin-asociated glycoprotein. Proc. Natl. Acad. Sci. USA. 93:814-818.