메뉴 건너뛰기




Volumn 38, Issue 3, 1997, Pages 469-481

Changes in fatty acid metabolism in rat hepatocytes in response to dietary n-3 fatty acids are associated with changes in the intracellular metabolism and secretion of apolipoprotein B-48

Author keywords

fatty acid esterification; fatty acid oxidation; ketogenesis; monounsaturated fat; phospholipids; triaclyglycerol; very low density lipoprotein

Indexed keywords

FISH OIL; OMEGA 3 FATTY ACID;

EID: 0030989832     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (45)

References (48)
  • 1
    • 0027957527 scopus 로고
    • Fish consumption and risk of stroke. The Zutphen Study
    • Keli, S. O., E. J. Feskens, and D. Kromhout. 1994. Fish consumption and risk of stroke. The Zutphen Study. Stroke. 25: 328-332.
    • (1994) Stroke , vol.25 , pp. 328-332
    • Keli, S.O.1    Feskens, E.J.2    Kromhout, D.3
  • 2
    • 0027179312 scopus 로고
    • Epidemiologic studies on Eskimos and fish intake
    • Feskens, E. J., and D. Kromhout. 1993. Epidemiologic studies on Eskimos and fish intake. Ann. N.Y. Acad. Sci. 683: 9-15.
    • (1993) Ann. N.Y. Acad. Sci. , vol.683 , pp. 9-15
    • Feskens, E.J.1    Kromhout, D.2
  • 3
    • 0028123672 scopus 로고
    • Effect of dietary fish oil on blood levells of free fatty acids, ketone bodies and triacylglycerol in humans
    • Dagnelie, P. C., T. Rietveld, G. R. Swart, T. Stijnen, and J. W. van den Berg. 1994. Effect of dietary fish oil on blood levells of free fatty acids, ketone bodies and triacylglycerol in humans. Lipids. 29: 41-45.
    • (1994) Lipids , vol.29 , pp. 41-45
    • Dagnelie, P.C.1    Rietveld, T.2    Swart, G.R.3    Stijnen, T.4    Van Den Berg, J.W.5
  • 7
    • 0028361107 scopus 로고
    • Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: Relative contribution of small, dense LDL to coronary heart disease risk
    • Griffin, B. A., D. J. Freeman, G. W. Tait, J. Thomson, M. J. Caslake, C. J. Packard, and J. Shepherd. 1994. Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis. 106: 241-253.
    • (1994) Atherosclerosis , vol.106 , pp. 241-253
    • Griffin, B.A.1    Freeman, D.J.2    Tait, G.W.3    Thomson, J.4    Caslake, M.J.5    Packard, C.J.6    Shepherd, J.7
  • 8
    • 0027067999 scopus 로고
    • Triglyceride levels and the risk of coronary artery disease: A view from Australia
    • Simons, L. A. 1992. Triglyceride levels and the risk of coronary artery disease: a view from Australia. Am. J. Cardiol. 70: 14H-18H.
    • (1992) Am. J. Cardiol. , vol.70
    • Simons, L.A.1
  • 9
    • 0024558773 scopus 로고
    • Plasma triglyceride as a risk factor for coronary heart disease. The epidemiologic evidence and beyond
    • Austin, M. A. 1989. Plasma triglyceride as a risk factor for coronary heart disease. The epidemiologic evidence and beyond. Am. J. Epidemiol. 129: 249-259.
    • (1989) Am. J. Epidemiol. , vol.129 , pp. 249-259
    • Austin, M.A.1
  • 10
    • 0027168937 scopus 로고
    • Pharmacological control of hypertriglyceridemia
    • Franceschini, G., and R. Paoletti. 1993. Pharmacological control of hypertriglyceridemia. Cardiovasc. Drugs Ther. 7: 297-302.
    • (1993) Cardiovasc. Drugs Ther. , vol.7 , pp. 297-302
    • Franceschini, G.1    Paoletti, R.2
  • 11
    • 0028245446 scopus 로고
    • Fish oils and their possible role in the treatment of cardiovascular diseases
    • Semplicini, A., and R. Valle. 1994. Fish oils and their possible role in the treatment of cardiovascular diseases. Pharmacol. Ther. 61: 385-397.
    • (1994) Pharmacol. Ther. , vol.61 , pp. 385-397
    • Semplicini, A.1    Valle, R.2
  • 12
    • 0025283305 scopus 로고
    • Assembly and secretion of hepatic very-low-density lipoprotein
    • Gibbons, G. F. 1990. Assembly and secretion of hepatic very-low-density lipoprotein. Biochem. J. 268: 1-13.
    • (1990) Biochem. J. , vol.268 , pp. 1-13
    • Gibbons, G.F.1
  • 13
    • 0028115062 scopus 로고
    • Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion
    • Sparks, J. D., and C. E. Sparks. 1994. Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion. Biochim. Biophys. Acta. 1215: 9-32.
    • (1994) Biochim. Biophys. Acta , vol.1215 , pp. 9-32
    • Sparks, J.D.1    Sparks, C.E.2
  • 15
    • 0024334111 scopus 로고
    • Fish oils and plasma lipid and lipoprotein metabolism in humans: A critical review
    • Harris, W. S. 1989. Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review. J. Lipid Res. 30: 785-807.
    • (1989) J. Lipid Res. , vol.30 , pp. 785-807
    • Harris, W.S.1
  • 16
    • 0025608989 scopus 로고
    • Fish oil fatty acids impair VLDL assembly and/or secretion by cultured rat hepatocytes
    • Lang, C. A., and R. A. Davis. 1990. Fish oil fatty acids impair VLDL assembly and/or secretion by cultured rat hepatocytes. J. Lipid Res. 31: 2079-2086.
    • (1990) J. Lipid Res. , vol.31 , pp. 2079-2086
    • Lang, C.A.1    Davis, R.A.2
  • 17
    • 0028889677 scopus 로고
    • Dietary medium-chain fatty acids raise and (n-3) polyunsaturated fatty acids lower hepatic triacylglycerol synthesis in rats
    • Geelen, M. J., W. J. Schools, C. Bijleveld, and A. C. Beynen. 1995. Dietary medium-chain fatty acids raise and (n-3) polyunsaturated fatty acids lower hepatic triacylglycerol synthesis in rats. J. Nutr. 125: 2449-2456.
    • (1995) J. Nutr. , vol.125 , pp. 2449-2456
    • Geelen, M.J.1    Schools, W.J.2    Bijleveld, C.3    Beynen, A.C.4
  • 18
    • 0024215029 scopus 로고
    • Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A:1,2-diacylglycerol acyltransferase
    • Rustan, A. C., J. O. Nossen, E. N. Christiansen, and C. A. Drevon. 1988. Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A:1,2-diacylglycerol acyltransferase. J. Lipid Res. 29: 1417-1426.
    • (1988) J. Lipid Res. , vol.29 , pp. 1417-1426
    • Rustan, A.C.1    Nossen, J.O.2    Christiansen, E.N.3    Drevon, C.A.4
  • 19
    • 0025250377 scopus 로고
    • Effect of fish-oil diet on hepatic lipid metabolism in non-human primates: Lowering of secretion of hepatic triglyceride but not apoB
    • Parks, J. S., F. L. Johnson, M. D. Wilson, and L. L. Rudel. 1990. Effect of fish-oil diet on hepatic lipid metabolism in non-human primates: lowering of secretion of hepatic triglyceride but not apoB. J. Lipid Res. 31: 455-466.
    • (1990) J. Lipid Res. , vol.31 , pp. 455-466
    • Parks, J.S.1    Johnson, F.L.2    Wilson, M.D.3    Rudel, L.L.4
  • 20
    • 0026021222 scopus 로고
    • Differential effects of eicosapentaenoic acid and oleic acid on lipid synthesis and secretion by HepG2 cells
    • Homan, R., J. E. Grossman, and H. J. Pownall. 1991. Differential effects of eicosapentaenoic acid and oleic acid on lipid synthesis and secretion by HepG2 cells. J. Lipid Res. 32: 231-241.
    • (1991) J. Lipid Res. , vol.32 , pp. 231-241
    • Homan, R.1    Grossman, J.E.2    Pownall, H.J.3
  • 21
    • 0027252120 scopus 로고
    • N-3 fatty acids stimulate intracellular degradation of apoprotein B in rat hepatocytes
    • Wang, H., X. Chen, and E. A. Fisher. 1993. N-3 fatty acids stimulate intracellular degradation of apoprotein B in rat hepatocytes. J. Clin. Invest. 91: 1380-1389.
    • (1993) J. Clin. Invest. , vol.91 , pp. 1380-1389
    • Wang, H.1    Chen, X.2    Fisher, E.A.3
  • 22
    • 0028235133 scopus 로고
    • The effects of n-3 fatty acids on the secretion of carboxyl-terminally truncated forms of human apoprotein B
    • Wang, H., Z. Yao, and E. A. Fisher. 1994. The effects of n-3 fatty acids on the secretion of carboxyl-terminally truncated forms of human apoprotein B. J. Biol. Chem. 269: 18514-18520.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18514-18520
    • Wang, H.1    Yao, Z.2    Fisher, E.A.3
  • 23
    • 0028036640 scopus 로고
    • Studies on the assembly of apolipoprotein B-100 and B-48-containing VLDL in McA-RH7777 cells
    • Boren, J., S. Rustaeus, and S. O. Olofsson. 1994. Studies on the assembly of apolipoprotein B-100 and B-48-containing VLDL in McA-RH7777 cells. J. Biol. Chem. 269: 25879-25888.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25879-25888
    • Boren, J.1    Rustaeus, S.2    Olofsson, S.O.3
  • 24
    • 0028919913 scopus 로고
    • Assembly of very low density lipoprotein in rat liver: A study of nascent particles recovered from the rough endoplasmic reticulum
    • Swift, L. L. 1995. Assembly of very low density lipoprotein in rat liver: a study of nascent particles recovered from the rough endoplasmic reticulum. J. Lipid Res. 36: 395-406.
    • (1995) J. Lipid Res. , vol.36 , pp. 395-406
    • Swift, L.L.1
  • 25
    • 0029944354 scopus 로고    scopus 로고
    • Selective recruitment of apoB-48 for the assembly of VLDL in rat triacylglycerol-enriched hepatocytes
    • Coussons, P. J., C. S. Bourgeois, D. Wiggins, and G. F. Gibbons. 1996. Selective recruitment of apoB-48 for the assembly of VLDL in rat triacylglycerol-enriched hepatocytes. Arterioscler Thromb. Vasc. Biol. 16: 889-897.
    • (1996) Arterioscler Thromb. Vasc. Biol. , vol.16 , pp. 889-897
    • Coussons, P.J.1    Bourgeois, C.S.2    Wiggins, D.3    Gibbons, G.F.4
  • 26
    • 0028085432 scopus 로고
    • Dietary polyunsaturated fatty acid regulation of gene transorption
    • Clarke, S. P., and D. B. Jump. 1994. Dietary polyunsaturated fatty acid regulation of gene transorption. Annu. Rev. Nutr. 14: 83-98.
    • (1994) Annu. Rev. Nutr. , vol.14 , pp. 83-98
    • Clarke, S.P.1    Jump, D.B.2
  • 27
    • 0027185720 scopus 로고
    • The hypotriglyceridemic effect of eicosapentaenoic acid in rats is reflected in increased mitochondrial fatty acid oxidation followed by diminished lipogenesis
    • Willumsen, N., J. Skorve, S. Hexeberg, A. C. Rustan, and R. K. Berge. 1993. The hypotriglyceridemic effect of eicosapentaenoic acid in rats is reflected in increased mitochondrial fatty acid oxidation followed by diminished lipogenesis. Lipids. 28: 683-690.
    • (1993) Lipids , vol.28 , pp. 683-690
    • Willumsen, N.1    Skorve, J.2    Hexeberg, S.3    Rustan, A.C.4    Berge, R.K.5
  • 28
    • 0029042515 scopus 로고
    • Quantification in vivo of the effects of different types of dietary fat on the loci of control involved in hepatic triacylglycerol secretion
    • Moir, A. M., B. S. Park, and V. A. Zammit. 1995. Quantification in vivo of the effects of different types of dietary fat on the loci of control involved in hepatic triacylglycerol secretion. Biochem. J. 308: 537-542.
    • (1995) Biochem. J. , vol.308 , pp. 537-542
    • Moir, A.M.1    Park, B.S.2    Zammit, V.A.3
  • 29
    • 0026545285 scopus 로고
    • Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed ω-3 and ω-6 fatty acids
    • Rustan, A. C., E. N. Christiansen, and C. A. Drevon. 1992. Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed ω-3 and ω-6 fatty acids. Biochem. J. 283: 333-339.
    • (1992) Biochem. J. , vol.283 , pp. 333-339
    • Rustan, A.C.1    Christiansen, E.N.2    Drevon, C.A.3
  • 30
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch, J., M. Lees, and G. H. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509.
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane-Stanley, G.H.3
  • 31
    • 0016710260 scopus 로고
    • Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations
    • Michalopoulos, G., and H. C. Pitot. 1975. Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations. Exp. Cell Res. 94: 70-78.
    • (1975) Exp. Cell Res. , vol.94 , pp. 70-78
    • Michalopoulos, G.1    Pitot, H.C.2
  • 32
    • 0014670025 scopus 로고
    • Hepatic lipid metabolism in experimental diabetes. V. The effect of concentrations of oleate on metabolism of triglycerides and ketogenesis
    • van Harken, D. R., C. W. Dixon, and M. Heimberg. 1969. Hepatic lipid metabolism in experimental diabetes. V. The effect of concentrations of oleate on metabolism of triglycerides and ketogenesis. J. Biol. Chem. 244: 2278-2285.
    • (1969) J. Biol. Chem. , vol.244 , pp. 2278-2285
    • Van Harken, D.R.1    Dixon, C.W.2    Heimberg, M.3
  • 33
    • 0025600431 scopus 로고
    • Storage, mobilization and secretion of cytosolic triacylglycerol in hepatocyte cultures. The role of insulin
    • Duerden, J. M., and G. F. Gibbons. 1990. Storage, mobilization and secretion of cytosolic triacylglycerol in hepatocyte cultures. The role of insulin. Biochem. J. 272: 583-587.
    • (1990) Biochem. J. , vol.272 , pp. 583-587
    • Duerden, J.M.1    Gibbons, G.F.2
  • 35
    • 9044249405 scopus 로고
    • Enzymic determination of D-( - )-β-hydroxybutyric acid and acetoacetic acid in blood
    • Williamson, D. H., J. Mellanby, and H. A. Krebs. 1962. Enzymic determination of D-( - )-β-hydroxybutyric acid and acetoacetic acid in blood. Biochem. J. 82: 90-96.
    • (1962) Biochem. J. , vol.82 , pp. 90-96
    • Williamson, D.H.1    Mellanby, J.2    Krebs, H.A.3
  • 36
    • 0026526715 scopus 로고
    • The role of pancreatic hormones in the regulation of lipid storage, oxidation and secretion in primary cultures of rat hepatocytes. Short- and long-term effects
    • Björnsson, 'O. G., J. M. Duerden, S. M. Bartlett, J. D. Sparks, C. E. Sparks, and G. F. Gibbons. 1992. The role of pancreatic hormones in the regulation of lipid storage, oxidation and secretion in primary cultures of rat hepatocytes. Short- and long-term effects. Biochem. J. 281: 381-386.
    • (1992) Biochem. J. , vol.281 , pp. 381-386
    • Björnsson, O.G.1    Duerden, J.M.2    Bartlett, S.M.3    Sparks, J.D.4    Sparks, C.E.5    Gibbons, G.F.6
  • 37
    • 0027242108 scopus 로고
    • Restoration in vitro of normal rates of very-low-density lipoprotein triacylglycerol and apoprotein B secretion in hepatocyte cultures from diabetic rats
    • Duerden, J. M., and G. F. Gibbons. 1993. Restoration in vitro of normal rates of very-low-density lipoprotein triacylglycerol and apoprotein B secretion in hepatocyte cultures from diabetic rats. Biochem. J. 294: 167-171.
    • (1993) Biochem. J. , vol.294 , pp. 167-171
    • Duerden, J.M.1    Gibbons, G.F.2
  • 38
    • 6544229829 scopus 로고
    • A study of the conditions and mechanism of the diphenylamine reaction for the colourimetric estimation of deoxyribonucleic acid
    • Burton, K. 1956. A study of the conditions and mechanism of the diphenylamine reaction for the colourimetric estimation of deoxyribonucleic acid. Biochem. J. 62: 315-323.
    • (1956) Biochem. J. , vol.62 , pp. 315-323
    • Burton, K.1
  • 39
    • 0024413643 scopus 로고
    • Eicosapentaenioc acid inhibits hepatic production of very low density lipoprotein
    • Rustan, A. C., and C. A. Drevon. 1989. Eicosapentaenioc acid inhibits hepatic production of very low density lipoprotein. J. Intern. Med. Suppl. 225: 31-38.
    • (1989) J. Intern. Med. Suppl. , vol.225 , pp. 31-38
    • Rustan, A.C.1    Drevon, C.A.2
  • 40
    • 0021333269 scopus 로고
    • The adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver
    • Wong, S. H., P. J. Nestel, R. P. Trimble, G. B. Storer, R. J. Illman, and D. L. Topping. 1984. The adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver. Biochim. Biophys. Acta. 792: 103-109.
    • (1984) Biochim. Biophys. Acta , vol.792 , pp. 103-109
    • Wong, S.H.1    Nestel, P.J.2    Trimble, R.P.3    Storer, G.B.4    Illman, R.J.5    Topping, D.L.6
  • 41
    • 0027498292 scopus 로고
    • Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats
    • Willumsen, N., S. Hexeberg, J. Skorve, M. Lundquist, and R. K. Berge. 1993. Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats. J. Lipid Res. 34: 13-22.
    • (1993) J. Lipid Res. , vol.34 , pp. 13-22
    • Willumsen, N.1    Hexeberg, S.2    Skorve, J.3    Lundquist, M.4    Berge, R.K.5
  • 42
    • 0024368071 scopus 로고
    • Effects of eicosapentaenoic and docosahexaenoic acids on apoprotein B mRNA and secretion of very low density lipoprotein in HepG2 cells
    • Wong, S. H., E. A. Fisher, and J. B. Marsh. 1989. Effects of eicosapentaenoic and docosahexaenoic acids on apoprotein B mRNA and secretion of very low density lipoprotein in HepG2 cells. Arteriosclerosis. 9: 836-841.
    • (1989) Arteriosclerosis , vol.9 , pp. 836-841
    • Wong, S.H.1    Fisher, E.A.2    Marsh, J.B.3
  • 43
    • 0028180094 scopus 로고
    • A comparison of in vitro models to study hepatic lipid and lipoprotein metabolism
    • Gibbons, G. F. 1994. A comparison of in vitro models to study hepatic lipid and lipoprotein metabolism. Curr. Opin. Lipidol. 5: 191-199.
    • (1994) Curr. Opin. Lipidol. , vol.5 , pp. 191-199
    • Gibbons, G.F.1
  • 44
    • 0021969805 scopus 로고
    • Regulated biosynthesis and divergent metabolism of three forms of hepatic apolipoprotein B in the rat
    • Windmueller, H. G., and A. E. Spaeth. 1985. Regulated biosynthesis and divergent metabolism of three forms of hepatic apolipoprotein B in the rat. J. Lipid Res. 26: 70-81.
    • (1985) J. Lipid Res. , vol.26 , pp. 70-81
    • Windmueller, H.G.1    Spaeth, A.E.2
  • 45
    • 0022401768 scopus 로고
    • Intrahepatic assembly of very low density lipoproteins. Varied synthetic response of individual apolipoproteins to fasting
    • Davis, R. A., J. R. Boogaerts, R. A. Borchardt, M. Malone-McNeil, and J. Archambault-Schexnayder. 1985. Intrahepatic assembly of very low density lipoproteins. Varied synthetic response of individual apolipoproteins to fasting. J. Biol. Chem. 260: 14137-14144.
    • (1985) J. Biol. Chem. , vol.260 , pp. 14137-14144
    • Davis, R.A.1    Boogaerts, J.R.2    Borchardt, R.A.3    Malone-McNeil, M.4    Archambault-Schexnayder, J.5
  • 46
    • 0023846290 scopus 로고
    • Developmental coordinate expression of triacylglycerol and small molecular weight apoB synthesis and secretion by rat hepatocytes
    • Coleman, R. A., E. B. Haynes, T. M. Sand, and R. A. Davis. 1988. Developmental coordinate expression of triacylglycerol and small molecular weight apoB synthesis and secretion by rat hepatocytes. J. Lipid Res. 29: 33-42.
    • (1988) J. Lipid Res. , vol.29 , pp. 33-42
    • Coleman, R.A.1    Haynes, E.B.2    Sand, T.M.3    Davis, R.A.4
  • 47
    • 0025121010 scopus 로고
    • Fasting decreases apoB mRNA editing and the secretion of small molecular weight apoB by rat hepatocytes
    • Leighton, J. K., J. Joyner, J. Zamarripa, M. Deines, and R. A. Davis. 1990. Fasting decreases apoB mRNA editing and the secretion of small molecular weight apoB by rat hepatocytes. J. Lipid Res. 31: 1663-1668.
    • (1990) J. Lipid Res. , vol.31 , pp. 1663-1668
    • Leighton, J.K.1    Joyner, J.2    Zamarripa, J.3    Deines, M.4    Davis, R.A.5
  • 48


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.