Gut epithelial cells as targets for gene therapy of hemophilia

Human Gene Therapy

Volumn 8, Issue 12, 1997, Pages 1481-1490

  Lozier, Jay N ^a,d   Morgan, Richard A ^a,b,c  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; LIPOSOME; RECOMBINANT PROTEIN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HEMOPHILIA; HUMAN; HUMAN CELL; INTESTINE; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; NONHUMAN; PROTEIN SECRETION; PROTEIN SYNTHESIS; RETROVIRUS; VIRUS TITRATION;

ADENOVIRIDAE; ANIMALIA; SUIDAE; UNIDENTIFIED RETROVIRUS;

EID: 16944362534     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.12-1481     Document Type: Article

References (4)

1. ALTMANN, G.G., and ENESCO, M. (1967). Cell number as a measure of distribution and renewal of epithelial cells in the small intestine of growing and adult rats. Am. J. Anat. 121, 319-336.
2. CHEN, L., PERLICK H., and MORGAN, R.A. (1997). Comparison of retroviral and adeno-associated viral vectors designed to express human clotting factor IX. Hum. Gene Ther. 8, 125-135.
3. CHUAH, M.K.L., VANDENDRIESSCHE, T., and MORGAN, R.A. (1995). Development and analysis of retroviral vectors expressing human factor VIII as a potential gene therapy for hemophilia A. Hum. Gene Ther. 6, 1363-1377.
4. CONNELLY, S., SMITH, T.A.G., DHIR, G., GARDNER, J.M., MEHAFFEY, M.G., ZARET, K.S., McCLELLAND, A., and KALEKO, M. (1995). In vivo gene delivery and expression of physiological levels of functional human factor VIII in mice. Hum. Gene Ther. 6, 185-193.