A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats

Surgery

Volumn 133, Issue 2, 2003, Pages 197-206

  Takeda, Keisa ^a   Jin, Maeng Bong ^a   Fujita, Miri ^a   Fukai, Moto ^a   Sakurai, Tsunenori ^a   Nakayama, Masato ^a   Taniguchi, Masahiko ^a   Suzuki, Tomomi ^a   Shimamura, Tsuyoshi ^a   Furukawa, Hiroyuki ^a   Todo, Satoru ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; COMPLEMENT MEMBRANE ATTACK COMPLEX; ENDOTHELIN 1; HYALURONIC ACID; INTERCELLULAR ADHESION MOLECULE 1; MALONALDEHYDE; MYELOPEROXIDASE; RHO ASSOCIATED COILED COIL FORMING PROTEIN KINASE 1; RHO KINASE; UNCLASSIFIED DRUG;

ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; CARDIOPULMONARY HEMODYNAMICS; CONTROLLED STUDY; CYTOARCHITECTURE; DRUG ACTIVITY; ENZYME ACTIVITY; HYPOTHESIS; LIVER BLOOD FLOW; LIVER FUNCTION TEST; LIVER ISCHEMIA; LIVER PRESERVATION; LIVER RESECTION; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SPECIES COMPARISON; STAINING; SURVIVAL TIME; TISSUE SECTION;

EID: 0037305149     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1067/msy.2003.59     Document Type: Article

References (54)

1. Jaeschke H, Farhood A, Smith CW. Neutrophil contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J 1990;4:3355-9.
2. Martinez-Mier G, Toledo-Pereyra LH, Ward PA. Adhesion molecules in liver ischemia and reperfusion. J Surg Res 2000;94:185-94.
3. Menger MD, Richter S, Yamauchi J, Vollmar B. Role of microcirculation in hepatic ischemia/reperfusion injury. Hepatogastroenterology 1999;46:1452-7.
4. Urakami A, Todo S, Zhu Y, Zhang S, Jin MB, Ishizaki N, et al. Attenuation of ischemic liver injury by monoclonal anti-endothelial antibody, AwETN40. J Am Coll Surg 1997;185:358-64.
5. Shimamura T, Zhu Y, Zhang S, Jin MB, Ishizaki N, Urakami A, et al. Protective role of nitric oxide in ischemia reperfusion injury of the liver. J Am Coll Surg 1999;188:43-52.
6. Totsuka E, Todo S, Zhu Y, Ishizaki N, Kawashima Y, Jin MB, et al. Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483. J Am Coll Surg 1998;187:276-86.
7. Koo A, Komatsu H, Tao G, Inoue M, Guth PH, Kaplowitz N. Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: evidence for a role for superoxide anion. Hepatology 1991;15:507-14.
8. Grattagliano I, Vendemiale G, Lauterburg BH. Reperfusion injury of the liver: role of mitochondria and protection by glutathione ester. J Surg Res 1999;86:2-8.
9. Ross SD, Tribble CG, Gaughen JR Jr, Shockey KS, Parrino PE, Kron IL. Reduced neutrophil infiltration protects against lung reperfusion injury after transplantation. Ann Thorac Surg 1999;67:1428-33.
10. Dulkanchainun TS, Goss JA, Imagawa DK, Shaw GD, Anselmo DM, Kalas F, et al. Reduction of hepatic ischemia/reperfusion injury by a soluble P-selectin glycoprotein ligand-1. Ann Surg 1998;227:832-40.
11. Jaschke H, Farhood A, Bautista AP, Spolarics Z, Spitzer JJ, Smith CW. Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver. Hepatology 1993;17:915-23.
12. Leung T, Chen XQ, Manser E, Lim L. The p160 Rho A-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol 1996;16:5313-27.
13. Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, Matsuura Y, et al. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science;275:1308-11.
14. Ishizaki T, Naito M, Fujisawa K, Maekawa M, Watanabe N, Saito Y, et al. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett 1997;404;118-24.
15. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997;389:990-4.
16. Kawaguchi A, Ohmori M, Harada K, Tsuruoka S, Sugimoto K, Fujimura A. The effect of a Rho kinase inhibitor Y-27632 on superoxide production, aggregation and adhesion in human polymorphonuclear leukocytes. Eur J Pharmacol 2000;403:203-8.
17. Niggli V. Rho-kinase in human neutrophils: a role in signaling for myosin light chain phosphorylation and cell migration. FEBS Lett 1999;445:69-72.
18. Kawada N, Seki S, Kuroki T, Kaneda K. ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1. Biochem Biophys Res Commun 1999;266:296-300.
19. Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med 1999;5:221-5.
20. Takamura M, Sakamoto M, Genda T, Asakura H, Hirohashi S. Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632. Hepatology 2001;33:577-81.
21. Kawano K, Kim Y, Kaketani K, Kobayashi M. The beneficial effect of cyclosporine on liver ischemia in rats. Transplantation 1989;48:759-64.
22. Chichibu K, Matsuura T, Shichijo S, Yokoyama MM. Assay of serum hyaluronic acid in clinical application. Clin Chim Acta 1989;181:317-24.
23. Henson PM, zanolari B, Schwartzman NA, Hong SR. Intracellular control of human neutrophil secretion. I. C5a-induced stimulus-specific deseneotozation and the effects of cytochalasin B J Immunol 1978;121:851-5.
24. Suzuki S, Toledo-Pereyra LH, Rodriguez FJ, Cejalvo D. Neutrophil infiltration as an important factor in liver ischemia and reperfusion. Transplantation 1993;55:1265-72.
25. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;11:493-501.
26. Narumiya S. The small GTPase Rho: cellular functions and signal transduction. J Biochem 1996;120:215-28.
27. Bauer M, Retzer M, Wilde JI, Maschberger P, Essler M, Aepfelbacher M, et al. Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets. Blood 1999;94:1665-72.
28. 2+ -sensitization of smooth muscle. FEBS Lett 1998;440:183-7.
29. Hirose M, Ishizaki T, Watanabe N, Uehata M, Kranenburg O, Moolenaar WH, et al. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J cell Biol 1998;141:1625-36.
30. Kuwahara K, Saito Y, Nakagawa O, Kishimoto I, Harada M, Ogawa E, et al. The effects of the selective ROCK inhibitor, Y-27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes: Possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy. FEBS Lett 1999;452:314-8.
31. Klages B, Brandt U, Simon MI, Schultz G, Offermanns S. Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 1999;144:745-54.
32. Vollmar B, Glasz J, Menger MD, Messmer K. Leukocytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence. Surgery 1995;117:195-200.
33. Miyamoto S, Teramoto H, Coso OA, Gutkind JS, Burbelo PD, Akiyama SK, et al. Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol 1995;131:791-807.
34. Hotchin NA, Hall A. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol 1995;131:1857-65.
35. Sans E, Delachanal E, Duperray A. Analysis of the roles of ICAM-1 in neutrophil transmigration using a reconstituted mammalian cell expression model: implication of ICAM-1 cytoplasmic domain and Rho-dependent signaling pathway. J Immune 2001;166:544-51.
36. Buckley GB. Reactive oxygen metabolites and reperfusion injury: aberrant triggering of reticuloendothelial function. Lancet 1994;344:934-6.
37. Toledo-Pereyra LH, Suzuki S. Neutrophils, cytokines, and adhesion molecules in hepatic ischemia and reperfusion injury. J Am Coll Surg 1994;179:758-62.
38. Hammerschmidt S, Wahn H. Comparable effects of HOCL and of FMLP-stimulated PMN on the circulation in an isolated lung model. Am J Respir Crit Care Med 1997;156:924-31.
39. Komatsu H, Koo A, Ghadishah E, Zeng H, Kuhlenkamp JF, Inoue M, et al. Neutrophil accumulation in ischemic reperfused rat liver: evidence for a role for superoxide free radicals. Am J Pathol 1992;262:G669-G676.
40. Yamaguchi Y, Akizuki E, Ichiguchi O, Matsumura F, Goto M, Miyanari N, et al. Neutrophil elastase inhibitor reduces neutrophil chemoattractant production after ischemia-reperfusion in rat liver. Gastroenterology 1997:112:551-60.
41. Terajima H, Yagi T, Shirakata H, Shinohara H, Satoh S, Arima Y, et al. Assessment of hyaluronate clearance and endothelin production during extracorporeal xenogeneic pig liver perfusion. Transplant Proc 1996;28:633-4.
42. Shimizu H, He W, Glu P, Dziadkoviec I, Miyazaki M, Falk RE. Serum hyaluronate in the assessment of liver endothelial cell function after orthotopic liver transplantation in the rat. Hepatology 1994;20:1323-9.
43. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-5.
44. Rakugi H, Tabuchi Y, Nakamura M, Nagano M, Higashimori K, Mikami H, et al. Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia. Biochem Biophys Res Commun 1990;169:973-7.
45. Hughes AK, Stricklett PK, Padilla E, Koden DE. Effect of reactive oxygen species on endothelin-1 production by human mesangial cells. Kidney Int 1996;49:181-9.
46. Morita T, Kurihara H, Yoshizumi M, Maemura K, Sugiyama T, Nagai R, et al. Human polymorphonuclear leukocytes have dual effects on endothelin-1: the induction of endothelin-1 mRNA expression in vascular endothelial cells and modification of the endothelin-1 molecules. Heart Vessels 1993;8:1-6.
47. Kruse-Elliott KT, Whorton AR, Olson NC. Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. Shock 1998;9:40-5.
48. Gomez-Garre D, Guerra M, Lopez-Farre A, Caramelo C, Escanero J, Egido J. Aggregation of human polymorphonuclear leukocytes by endothelin: role of platelet-activating factor. Eur J Pharmacol 1992;224:167-72.
49. Todo S, Zhu Y, Zhang S, Jin MB, Ishizaki N, Tanaka H, et al. Attenuation of ischemic liver injury by augmentation of endogenous adenosine. Transplantation 1997;27:217-23.
50. Ishikawa H, Jin MB, Suzuki T, Shimamura T, Taniguchi M, Magata S, et al. Elevation of cyclic nucleotides attenuates ischemia and reperfusion injury of liver. Transplant Proc 2001;33:982-3.
51. Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, et al. Identification of the platelet ADP receptor targeted by antithrombotic drug. Nature 2001;409:202-7.
52. Laudanna C, Campbell JJ, Butcher EC. Elevation of intracellular camp inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants. J Biol Chem 1997;272:24141-4.
53. Yamauchi J, Hirasawa A, Miyamoto Y, Itoh H, Tsujimoto G. Beta2-adrenergic receptor/cyclic adenosine monophosphate (cAMP) leads to JNK activation through Rho family small GTPases. Biochem Biophys Res Commun 2001;284:1199-1203.
54. Ishizaki Y, Uehata M, Tamechika I, et al. Pharmacological properties of Y-27632, a specific inhibitor of Rho-associated kinases. Mol Pharmacol 2000;57:976-83.