Noggin arrests stromal cell differentiation in vitro

Bone

Volumn 32, Issue 2, 2003, Pages 111-119

  Gazzerro, E ^a,b   Du, Z ^a,b   Devlin, R D ^a   Rydziel, S ^a   Priest, L ^a   Economides, A N ^c   Canalis, E ^a,b  

^a SAINT FRANCIS HOSPITAL AND MEDICAL CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^c REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

Adipocytes; Bone morphogenetic proteins; Cytokines; Glucocorticoids; Growth factors; Osteoblasts

Indexed keywords

ADIPSIN; HYDROCORTISONE; MESSENGER RNA; NOGGIN; OSTEOCALCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; MOUSE; NONHUMAN; OSTEOBLAST; PROMOTER REGION; PROTEIN EXPRESSION; STROMA CELL; TRANSGENIC MOUSE; WILD TYPE;

EID: 0037291304     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(02)00948-1     Document Type: Article

References (52)

1. Delany A.M., Canalis E. Growth factors and bone. LeRoith D., Bondy C. Growth factors and cytokines in health and disease. Vol. III 3A:1997;127-155 JAI Press, Greenwich, CT.
2. Celeste A.J., Iannazzi J.A., Taylor R.C., Hewick R.M., Rosen V., Wang E.A., et al. Identification of transforming growth factor B family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci USA. 87:1990;9843-9847.
3. Gazzero E., Gangi V., Canalis E. Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. J Clin Invest. 102:1998;2106-2114.
4. Hughes F.J., Collyer J., Stanfield M., Goodman S.A. The effects of bone morphogenetic protein-2, -4, and -6 on differentiation of rat osteoblast cells in vitro. Endocrinology. 136:1995;2671-2677.
5. Schmitt J.M., Hwang K., Winn S.R., Hollinger J.O. Bone morphogenetic proteins an update on basic biology and clinical relevance . J Orthop Res. 17:1999;269-278.
6. Abe E., Yamamoto M., Taguchi Y., Lecka-Czernik B., O'Brien C.A., Economides A., et al. Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice antagonism by noggin . J Bone Miner Res. 15:2000;663-673.
7. Hwa V., Oh Y., Rosenfeld R.G. The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocr Rev. 20:1999;761-787.
8. Jones J.I., Clemmons D.R. Insulin-like growth factors and their binding proteins biological actions . Endocr Rev. 16:1995;3-34.
9. Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M. The Xenopus dorsalizing factor gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell. 1:1998;673-683.
10. Minabe-Saegusa C., Saegusa H., Tsukahara M., Noguchi S. Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach. Dev Growth Differ. 40:1998;343-353.
11. Pearce J.J.H., Penny G., Rossant J. A mouse cerberus/dan-related gene family. Dev Biol. 209:1999;98-110.
12. Piccolo S., Agius E., Leyns L., Bhattacharyya S., Grunz H., Bouwmeester T., et al. The head inducer cerberus is a multifunctional antagonist of nodal, BMP and Wnt signals. Nature. 397:1999;707-710.
13. Piccolo S., Sasai Y., Lu B., De Robertis E.M. Dorsoventral patterning in Xenopus inhibition of ventral signals by direct binding of chordin to BMP-4 . Cell. 86:1996;589-598.
14. Ray R.P., Wharton K.A. Twisted perspective new insights into extracellular modulation of BMP signaling during development . Cell. 104:2001;801-804.
15. Stanley E., Biben C., Kotecha S., Fabri L., Tajbakhsh S., Wang C.C., et al. DAN is a secreted glycoprotein related to Xenopus cerberus. Mech Dev. 77:1998;173-184.
16. Valenzuela D.M., Economides A.N., Rojas E., Lamb T.M., Nunez L., Jones P., et al. Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci. 15:1995;6077-6084.
17. Zimmerman L.B., DeJesus-Escobar J.M., Harland R.M. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein-4. Cell. 86:1996;599-606.
18. Aspenberg P., Jeppsson C., Economides A.N. The bone morphogenetic proteins antagonist noggin inhibits membranous ossification. J Bone Miner Res. 16:2001;497-500.
19. Chang C., Hemmati-Brivanlou A. Xenopus GDF6, a new antagonist of noggin and a partner of BMPs. Development. 126:1998;3347-3357.
20. Brunet L.J., McMahon J.A., McMahon A.P., Harland R.M. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science. 280:1998;1455-1457.
21. Gong Y., Krakow D., Marcelino J., Wilkin D., Chitayat D., Babul-Hirji R., et al. Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nature Genetics. 21:1999;302-304.
22. Chen D., Ji X., Harris M.A., Feng J.Q., Karsenty G., Celeste A.J., Rosen V., et al. Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol. 142:1998;295-305.
23. Prockop D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 276:1997;71-74.
24. Otsuka E., Yamaguchi A., Hirose S., Hagiwara H. Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid. Am J Physiol. 277:1999;C132-138.
25. Erlebacher A., Derynck R. Increased expression of TGF-β2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol. 132:1996;195-210.
26. Irwin N. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning. 1989;932-936 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
27. Dahl L.K. A simple and sensitive histochemical method for calcium. Proc Soc Exp Biol Med. 80:1952;474-479.
28. Wu Z., Xie Y., Morison R.F., Bucher N.L.R., Farmer S.R. PPARγ induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EPPα during the conversion of 3T3 into adipocytes. J Clin Invest. 101:1998;22-32.
29. Canalis E. Effect of glucocorticoids on type I collagen synthesis, alkaline phosphatase activity and deoxyribonucleic acid content in cultured rat calvariae. Endocrinology. 112:1983;931-939.
30. Dempster D.W., Moonga B.S., Stein L.S., Horbert W.R., Antakly T. Glucocorticoids inhibit bone resorption by isolated rat osteoclasts by enhancing apoptosis. J Endocrinol. 154:1997;397-406.
31. Laemmli U.K. Cleavage of structural protein during the assembly of the head bacteriophage T4. Nature. 277:1970;680-685.
32. Lennon G., Auffray C., Polymeropoulos M., Bento Soares M. The I.M.A.G.E. consortium an integrated molecular analysis of genomes and their expression . Genomics. 33:1996;151-152.
33. Lian J., Stewart C., Puchacz E., Mackowiak S., Shalhoub V., Collart D., et al. Structure of rat osteocalcin gene and regulation of vitamin D-dependent expression. Proc Natl Acad Sci USA. 86:1989;1143-1147.
34. Banerjee C., Javed A., Choi J., Green J., Rosen V., Van Wijnen A.J., et al. Differential regulation of the two principal runx2/Cbfa1 N-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype. Endocrinology. 142:2001;4026-4039.
35. Pereira R.C., Delany A.M., Canalis E. Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation. Correlation with CCAAT enhancer binding protein expression. Bone. 30:2002;685-691.
36. Yamaguchi A., Ishizuya T., Kintou N., Wada Y., Katagiri T., Wozney J.M., et al. Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem Biophys Res Commun. 220:1996;366-371.
37. Gimble J.M., Morgan C., Kelly K., Wu X., Dandapani V., Wang C.S., et al. Bone morphogenetic proteins inhibit adipocyte differentiation by bone marrow stromal cells. J Cell Biochem. 58:1995;393-402.
38. Pereira R.M.R., Delany A.M., Canalis E. Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture. Bone. 28:2001;484-490.
39. Frenkel B., Capparelli C., Van Auken M., Baran D., Bryan J., Stein J.L., et al. Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures effects of age and sex . Endocrinology. 138:1997;2109-2116.
40. Hay E., Lemonnier J., Fromigue O., Marie P.J. Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway. J Biol Chem. 276:2001;29028-29036.
41. Izumi M., Fujio Y., Kunisada K., Negoro S., Tone E., Funamoto M., et al. Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smadl pathway. J Biol Chem. 276:2001;31133-31231.
42. Thies R.S., Bauduy M., Ashton B.A., Kurtzberg L., Wozney J.M., Rosen V. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology. 130:1992;1318-1324.
43. Darlington G.J., Ross S.E., MacDougald O.A. The role of C/EBP genes in adipocyte differentiation. J Biol Chem. 273:1998;30057-30060.
44. Ducy P., Starbuch M., Priemel M., Shen J., Pinero G., Geoffroy V., et al. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev. 3:1999;1025-1036.
45. Ducy P., Zhang R., Geoffroy V., Ridall A.L., Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 89:1997;747-754.
46. Johnson P.F., McKnight S.L. Eukaryotic transcriptional regulatory proteins. Annu Rev Biochem. 58:1989;799-839.
47. Tanaka T., Yoshida N., Kishimoto T., Akira S. Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene. EMBO J. 16:1997;7432-7443.
48. Wu Z., Bucher N.L.R., Farmer S.R. Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids. Mol Cell Biol. 16:1996;4128-4136.
49. Xiao Z.S., Thomas R., Hinson T.K., Quarles L.D. Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. Gene. 214:1998;187-197.
50. Harada H., Tagashira S., Fujiwara M., Ogawa S., Katsumata T., Yamaguchi A., et al. Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem. 274:1999;6972-6978.
51. Sudhakar S., Katz M.S., Elango N. Analysis of type-I and type-II RUNX2 protein expression in osteoblasts. Biochem Biophys Res Commun. 286:2001;74-79.
52. Andress D.L. IGF-binding protein-5 stimulates osteoblast activity and bone accretion in ovariectomized mice. Am J Physiol. 281:2001;E283-288.