Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H, 5H)-acridinedione (A-184209) as a novel K ATP channel inhibitor

British Journal of Pharmacology

Volumn 138, Issue 2, 2003, Pages 393-399

  Gopalakrishnan, Murali ^a   Miller, Thomas R ^a   Buckner, Steven A ^a   Milicic, Ivan ^a   Molinari, Eduardo J ^a   Whiteaker, Kristi L ^a   Davis Taber, Rachel ^a   Scott, Victoria E ^a   Cassidy, Christopher ^a   Sullivan, James P ^a   Carroll, William A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

A 184209; ATP sensitive potassium channel; Dihydropyridine; K ATP channel inhibitor; K ATP channel opener; Urinary bladder; Vascular smooth muscle

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; 2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; 9 (3,4 DICHLOROPHENYL) 3,3,6,6 TETRAMETHYL 3,4,6,7,9,10 HEXAHYDRO 1,8(2H,5H) ACRIDINEDIONE; 9 (3,4 DICHLOROPHENYL) 3,4,6,7,9,10 HEXAHYDRO 1,8(2H,5H) ACRIDINEDIONE; A 184208; A 184209; A 312110; ADENOSINE TRIPHOSPHATE; DEOXYGLUCOSE; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; RADIOLIGAND; SULFONYLUREA RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA STRIP; ARTICLE; BLADDER MUSCLE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DRUG BINDING SITE; GUINEA PIG; HEART MUSCLE CELL; HUMAN; HUMAN CELL; LIGAND BINDING; MALE; NONHUMAN; PANCREAS CELL; PHARMACOPHORE; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; VASCULAR SMOOTH MUSCLE;

ACRIDINES; ANIMALS; AORTA, THORACIC; CELL LINE; DIHYDROPYRIDINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; MALE; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0037275189     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705048     Document Type: Article

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