Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes

Journal of Pharmacological and Toxicological Methods

Volumn 46, Issue 1, 2001, Pages 45-50

  Whiteaker, Kristi L ^a   Davis Taber, Rachel ^a   Scott, Victoria E S ^a   Gopalakrishnan, Murali ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

ATP sensitive potassium channel (KATP); DiBAC4(3) fluorescence; Glyburide (glibenclamide); Inwardly rectifying potassium channel (KIR); Membrane potential; Methods; Potassium channel opener; Rats; Ventricular cardiomyocytes

Indexed keywords

2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; ADENOSINE TRIPHOSPHATE; BARBITURIC ACID DERIVATIVE; BIS(1,3 DIBUTYLBARBITURIC ACID)TRIMETHINE OXONOL; CROMAKALIM; DIAZOXIDE; GLIBENCLAMIDE; N (4 BENZOYLPHENYL) 3,3,3 TRIFLUORO 2 HYDROXY 2 METHYLPROPIONAMIDE; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; FLUORESCENCE ANALYSIS; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART VENTRICLE; NONHUMAN; RAT;

ADENOSINE TRIPHOSPHATE; AMIDES; ANIMALS; ANIMALS, NEWBORN; BENZOPHENONES; CELLS, CULTURED; CROMAKALIM; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENCE; GLYBURIDE; GUANIDINES; HEART VENTRICLES; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; PINACIDIL; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SARCOLEMMA; VASODILATOR AGENTS;

ANIMALIA;

EID: 0035725988     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(02)00160-0     Document Type: Article

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