(-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3, 2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): A novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 1, 2002, Pages 379-386

  Gopalakrishnan, Murali ^a   Buckner, Steven A ^b   Whiteaker, Kristi L ^a   Shieh, Char Chang ^c   Molinari, Eduardo J ^a   Milicic, Ivan ^b   Daza, Anthony V ^a   Davis Taber, Rachel ^b   Scott, Victoria E ^a   Sellers, Donna ^b   Chess Williams, Russ ^a   Chapple, Christopher R ^b   Liu, Yi ^a   Liu, Dong ^b   Brioni, Jorge D ^a   Sullivan, James P ^a   Williams, Michael ^b   Carroll, William A ^a   Coghlan, Michael J ^a  

^a ABBOTT LABORATORIES   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c Icagen Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; 4 [3,4 DIOXO 2 (1,2,2 TRIMETHYLPROPYLAMINO) 1 CYCLOBUTENYLAMINO] 3 ETHYLBENZONITRILE; 4 [3,4 DIOXO 2 (1,2,2 TRIMETHYLPROPYLAMINO)CYCLOBUT 1 ENYLAMINO] 3 ETHYLBENZONITRILE; 9 (3 BROMO 4 FLUOROPHENYL) 2,3,5,6,7,9 HEXAHYDROTHIENO[3,2 B]QUINOLIN 8(4H) ONE 1,1 DIOXIDE; A 278637; ADENOSINE TRIPHOSPHATE; BENZONITRILE; BIS(1,3 DIBUTYLBARBITURIC ACID)TRIMETHINE OXONOL; CARBACHOL; GLIBENCLAMIDE; N (4 BENZOYLPHENYL) 3,3,3 TRIFLUORO 2 HYDROXY 2 METHYLPROPIONAMIDE; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLADDER CONTRACTION; BLADDER DISEASE; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SWINE;

AMIDES; ANIMALS; AORTA, THORACIC; ATP-BINDING CASSETTE TRANSPORTERS; BENZOPHENONES; CYCLIC S-OXIDES; CYCLOBUTANES; GUINEA PIGS; HUMANS; ION CHANNEL GATING; KINETICS; MALE; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; NITRILES; PATCH-CLAMP TECHNIQUES; PORTAL VEIN; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; URINARY BLADDER;

EID: 0036785473     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.034538     Document Type: Article

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