The identification of a potent imidazoline-based vascular K(ATP) channel antagonist

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 362, Issue 2, 2000, Pages 145-151

  Bell, K ^a   Favaloro, J ^a   Khalil, V ^a   Iskander, M M ^a   McPherson, G A ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Imidazolines; K(ATP) channel antagonists; K(ATP) channels; Levcromakalim; Pig coronary artery; Rat right atria; Smooth muscle relaxation

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 [N (2,6 DICHLOROPHENYL) N (4 FLUOROBENZYL)AMINO]IMIDAZOLINE; 2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; CLONIDINE DERIVATIVE; GLIBENCLAMIDE; IMID 1M; IMID 26F; IMIDAZOLINE DERIVATIVE; LEMAKALIM; NITROPRUSSIDE SODIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; SULFONYLUREA DERIVATIVE; TETRAPHENYLPHOSPHONIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA MEDIA; ARTICLE; BRAIN MEMBRANE; CATTLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; HEART RATE; HEART RIGHT ATRIUM; ISOLATED ARTERY; MALE; NONHUMAN; PKA; RAT; SWINE; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CATTLE; CLONIDINE; CORONARY VESSELS; CROMAKALIM; GLYBURIDE; GUANIDINES; HEART ATRIA; HEART RATE; HYPOGLYCEMIC AGENTS; IMIDAZOLES; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PYRIDINES; RADIOLIGAND ASSAY; RATS; SWINE; VASODILATOR AGENTS;

EID: 0033894998     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000261     Document Type: Article

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