(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the β-adrenoceptor

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 367, Issue 1, 2003, Pages 10-21

  Sarsero, Doreen ^a   Russell, Fraser D ^b   Lynham, James A ^c   Rabnott, Glenn ^d   Yang, Ian ^d   Fong, Kwun M ^d   Li, Li ^b   Kaumann, Alberto J ^c   Molenaar, Peter ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d THE PRINCE CHARLES HOSPITAL   (Australia)

Author keywords

( ) CGP 12177; ( ) Propranolol resistant 1 adrenoceptors; Cyclic AMP; Cyclic AMP dependent protein kinase; Heart failure; Human heart; Lusitropy; Positive inotropy

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; BETA 1 ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE INHIBITOR; PROPANOL;

ADULT; AGED; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; ENZYME ACTIVATION; FEMALE; GENETIC POLYMORPHISM; HEART FAILURE; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE RELAXATION; HEART RIGHT ATRIUM; HUMAN; HUMAN TISSUE; INOTROPISM; MAJOR CLINICAL STUDY; MALE;

ADULT; AGED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCLE RELAXATION; MYOCARDIAL CONTRACTION; MYOCARDIUM; PROPANOLAMINES; PROPRANOLOL; PROTEIN BINDING; RECEPTORS, ADRENERGIC, BETA-1; STIMULATION, CHEMICAL;

EID: 0037275048     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0652-9     Document Type: Article

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