The gain-of-function G389R variant of the β1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjects

Clinical Science

Volumn 99, Issue 3, 2000, Pages 233-238

  O'Shaughnessy, K M ^a   Fu, B ^a   Dickerson, C ^a   Thurston, D ^a   Brown, M J ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

G protein; Hypertension; Polymorphism; 1 adrenoceptor

Indexed keywords

ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; RECEPTOR SUBTYPE;

ADULT; AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HEART RATE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0033821403     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0990233     Document Type: Article

References (21)

1. Use of propranolol (Inderal) in the treatment of hypertension
2. Seminars in medicine of the Beth Israel Hospital, Boston. Adrenergic receptors - Evolving concepts and clinical implications
3. Beta-adrenergic receptors and receptor signaling in heart failure
4. Effects of the β 2-adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to β 1-adrenoceptor antagonists
5. Human tissue adrenergic receptors are not predictive of responses to epinephrine in vivo
6. The causes of essential hypertension
7. Renin profiling for diagnosis and treatment of hypertension
8. Oxidation phenotype - A major determinant of metoprolol metabolism and response
9. Association of Glu 27 β 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects
10. Mutations in the gene encoding for the β 2-adrenergic receptor in normal and asthmatic subjects
11. Characterization of a unique genetic variant in the β1-adrenoceptor gene and evaluation of its role in idiopathic dilated cardiomyopathy. CARDIGENE Group
12. Common polymorphisms of β1-adrenoceptor: Identification and rapid screening assay
13. A gain-of-function polymorphism in a G-protein coupling domain of the human β1-adrenergic receptor
14. Optimisation of antihypertensive treatment by crossover rotation of four major classes
15. Relation between initial blood pressure and its fall with treatment
16. Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension
17. Physiological aspects of primary hypertension
18. Plasma catecholamines and essential hypertension. An analytical review
19. Cyclic AMP-induced desensitization of G-protein-regulated phospholipase C in turkey erythrocyte membranes
20. G-protein coupled receptor kinases as modulators of G-protein signalling
21. Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in β2-adrenoreceptor desensitization