Comparison of the affinity of β-blockers for two states of the β1-adrenoceptor in ferret ventricular myocardium

British Journal of Pharmacology

Volumn 135, Issue 2, 2002, Pages 451-461

  Lowe, Martin D ^a   Lynham, James A ^a   Grace, Andrew A ^a   Kaumann, Alberto J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CGP12177; Ferret heart; adrenoceptor blocking agents

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ALPRENOLOL; ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; BUPRANOLOL; CARVEDILOL; ISOPRENALINE; METOPROLOL; NADOLOL; PINDOLOL; PROPRANOLOL DERIVATIVE; SOTALOL; TIMOLOL;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; FERRET; HEART MUSCLE; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; FERRETS; HEART VENTRICLES; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; RECEPTORS, ADRENERGIC, BETA-1; STIMULATION, CHEMICAL;

EID: 0036174668     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704450     Document Type: Article

References (46)

1. Some quantitative uses of drug antagonists
2. Convenient apparatus for recording contractions of isolated muscle
3. Receptor pharmacology of carvedilol in the human heart
4. 2-adrenergic receptor gene
5. Structure-basicity and structure-affinity relationships of β-adrenergic blocking agents
6. 2+ transients in mouse ventricular myocytes
7. 2-adrenoceptors of human heart. Differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by (-)-noradrenaline and (-)-adrenaline
8. 1-adrenergic receptor
9. 2-adrenoceptors in human atrium
10. Usefulness of pindolol in neurocardiogenic syncope
11. Potentiation of the effects of isoprenaline and noradrenaline by hydrocortisone in cat heart muscle
12. Adrenergic receptors in heart muscle. Two different mechanisms of β-blockers as partial agonists. Int. Union of Biochemistry, Symposium Nr 52
13. Cardiac β-adrenoceptors - Experimental viewpoints
14. 2-adrenoceptors activated by (-)-adrenaline in rat sinoatrial node
15. Is there a third heart β-adrenoceptor?
16. 4-like receptors
17. (-)-CGP12177-induced increase of human atrial contraction through a putative third β-adrenoceptor
18. Four β-adrenoceptor subtypes in the mammalian heart
19. 2-Adrenoceptor-mediated positive inotropic effects of adrenaline in human ventricular myocardium. Quantitative discrepancies between binding and adenylate cyclase stimulation
20. 3-adrenoceptor in the rat
21. Modulation of human cardiac function through 4 β-adrenoceptor populations
22. 2-adrenoceptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I and C protein in ventricular myocardium from patients with terminal heart failure
23. 4-adrenoceptor pharmacology
24. A comparison of the effects of adrenaline and noradrenaline on human heart: The role of adenylate cyclase and contractile force
25. 3-adrenoceptor knockout mice
26. 2-adrenoceptor activation by zinterol causes phosphorylation, contractile effects and relaxant effects through a cAMP pathway in human atrium
27. 4-adrenoceptor mediated responses occur in parallel in a rat model of cardiac failure
28. 3-adrenergic-independent effects of CGP12177 in brown adipose tissue
29. 1-adrenergic receptors
30. 2-adrenoceptor-mediated positive inotropic effect possibly unrelated to cyclic AMP
31. 3H]-ICI 118,551 and blocking potency of ICI 118,551
32. 2-adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (-)-atenolol
33. 1-adrenoceptors by carvedilol in ferret myocardium
34. 2-adrenoceptor-mediated effects
35. Pindolol acts as a beta-adrenoceptor agonist in orthostatic hypotension: Therapeutic implications
36. 2-adrenergic receptors to Gs-protein
37. 3H]-CGP 12177 for resolving subtype-selectivity of competing ligands
38. 1-adrenergic receptors
39. 2-adrenergic receptors
40. 4-adrenoceptor' in rat atrium
41. 3H]-CGP 12177 binding
42. Increased survival with β-blockers: Importance of ancillary properties
43. CGP-12177. A hydrophillic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells
44. Cardiac adrenergic receptor effects of carvedilol
45. Beta-blockade during and after myocardial infarction: An overview of the randomized trials