Suicide gene therapy using AAV-HSVtk/ganciclovir in combination with irradiation results in regression of human head and neck cancer xenografts in nude mice

Gene Therapy

Volumn 10, Issue 1, 2003, Pages 51-58

  Kanazawa, T ^a,b   Mizukami, H ^a,b   Okada, T ^a,b   Hanazono, Y ^a,b   Kume, A ^a,b   Nishino, H ^a   Takeuchi, K ^a   Kitamura, K ^c   Ichimura, K ^a   Ozawa, K ^a,b  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Adeno associated virus vector; Animal experiments; Head and neck neoplasms; Herpes simplex thymidine kinase; Irradiation

Indexed keywords

BETA GALACTOSIDASE; GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL CULTURE; CANCER GRAFT; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL COUNT; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GAMMA RADIATION; GENE EXPRESSION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; REVIEW; SUICIDE GENE THERAPY; TRANSGENE;

ANIMALS; ANTIVIRAL AGENTS; BETA-GALACTOSIDASE; COMBINED MODALITY THERAPY; DEPENDOVIRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GANCICLOVIR; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HEAD AND NECK NEOPLASMS; HELA CELLS; HUMANS; MICE; MICE, NUDE; RADIOTHERAPY DOSAGE; SIMPLEXVIRUS; THYMIDINE KINASE; TRANSDUCTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

ADENO-ASSOCIATED VIRUS; ANIMALIA; HUMAN HERPESVIRUS 1; MUS MUSCULUS; SIMPLEXVIRUS;

EID: 0037269104     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301837     Document Type: Review

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