Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus

Lancet

Volumn 351, Issue 9117, 1998, Pages 1702-1703

  Wagner, John A ^a   Reynolds, Thomas ^b   Moran, Mary Lynn ^b   Moss, Richard B ^b   Wine, Jeffrey J ^b   Flotte, Terence R ^b   Gardner, Phyllis ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TRANSMEMBRANE CONDUCTANCE REGULATOR; VIRUS ANTIBODY;

ADENO ASSOCIATED VIRUS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CYSTIC FIBROSIS; EXPRESSION VECTOR; GENE TRANSFER; HUMAN; MAXILLARY SINUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0032490381     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)77740-0     Document Type: Article

References (5)

1. 1 Flotte TR, Afione SA, Conrad C, et al. Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proc Natl Acad Sci USA 1993; 90: 10613-17.
2. 2 Conrad CK, Allen SS, Afione SA, et al. Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung. Gene Ther 1996; 3: 658-68.
3. 3 Moss RB, King VV. Management of sinusitis in cystic fibrosis by endoscopic surgery and serial antimicrobial lavage: reduction in recurrence requiring surgery. Arch Otolaryngol Head Neck Surg 1995; 121: 566-72.
4. 4 Wine JJ, King VV, Lewiston NJ. Method for rapid evaluation of topically applied agents to cystic fibrosis airways. Am J Physiol 1991; 261 (2pt 1): L218-21.
5. 5 Wagner JA, Moran ML, Messner AH, et al. A phase I/II study of tgAAV-CF for the treatment of chronic sinusitus in patients with cystic fibrosis. Hum Gene Ther 1998; 9: 889-909.