Treatment of lacZ plasmid-based transgenic mice with benzo[a]pyrene: Measurement of DNA adduct levels, mutant frequencies, and mutant spectra

Environmental and Molecular Mutagenesis

Volumn 34, Issue 2-3, 1999, Pages 140-147

  Boerrigter, Michaël E T I ^a  

^a Leven Inc   (United States)

Author keywords

Benzo a pyrene; DNA adducts; Mouse; Mutatians; Transgenic

Indexed keywords

BENZO[A]PYRENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DNA ADDUCT; DNA DAMAGE; DNA MODIFICATION; MOUSE; MUTATION RATE; NONHUMAN; RESTRICTION MAPPING; SOMATIC MUTATION; TRANSGENIC MOUSE;

ANIMALS; BENZO(A)PYRENE; DNA ADDUCTS; LAC OPERON; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PHOSPHORUS RADIOISOTOPES; PLASMIDS;

EID: 0032749588     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1999)34:2/3<140::AID-EM13>3.0.CO;2-J     Document Type: Article

References (22)

1. Boerrigter METI. 1998. High sensitivity for color mutants in lacZ plasmid-based transgenic mice, as detected by positive selection. Environ Mol Mutagen 32:148-154.
2. Boerrigter METI, Vijg J. 1997. Sources of variability in mutant frequency determinations in different organs of lacZ plasmid-based transgenic mice: experimental features and statistical analysis. Environ Mol Mutagen 29:221-229.
3. Boerrigter METI, Dolle MET, Martus H-J, Gossen JA, Vijg J. 1995a. Plasmid-based transgenic mouse model for studying in vivo mutations. Nature (Lond) 377:657-659.
4. Boerrigter METI, Wei JY, Vijg J. 1995b. Induction and repair of benzo[a]pyrene-DNA adducts in C57BL/6 and BALB/c mice: association with aging and longevity. Mech Ageing Dev 82:31-50.
5. Dolle MET, Martus H-J, Gossen JA, Boerrigter METI, Vijg J. 1996. Evaluation of a plasmid-based transgenic mouse model for detecting in vivo mutations. Mutagenesis 11:111-118.
6. Eastman A, Sweetenham J, Bresnick E. 1978. Comparison of in vivo and in vitro binding of polycyclic hydrocarbons to DNA. Chem Biol Interact 23:345-353.
7. Gelboin HW. 1980. Benzo[a]pyrene metabolism, activation, and carcino-genesis: role and regulation of mixed-function oxidases and related enzymes. Physiol Rev 60:1107-1166.
8. Ginsberg GL, Atherholt TB. 1989. Transport of DNA adducting metabolites in mouse serum following benzo[a]pyrene administration. Carcinogenesis 10:673-679.
9. Ginsberg GL, Atherholt TB. 1990. DNA adduct formation in mouse tissues in relation to serum levels of benzo[a]pyrene-diol-epoxide after injection of benzo[a]pyrene or the diol-epoxide. Cancer Res 50: 1189-1194.
10. Gossen JA, Martus H-J, Wei JY, Vijg J. 1995. Spontaneous and X-ray-induced deletion mutations in a lacZ plasmid-based transgenic mouse model. Mutat Res 331:89-97.
11. Heddle JA, Shaver-Walker P, Tao KS, Zhang XB. 1995. Treatment protocols for transgenic mutation assays in vivo. Mutagenesis 10:467-470.
12. Kulkarni MS, Anderson MW. 1984. Persistence of benzo[a]pyrene metabolite: DNA adducts in lung and liver of mice. Cancer Res 44:97-101.
13. Lei W, Yu R, Mandlekar S, Kong AN. 1998. Induction and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase-3) and c-Jun NH2-terminal kinase 1 by benzo[a]pyrene. Cancer Res 58:2102-2106.
14. 32P-postlabeling assay in mice of transplacental DNA damage induced by the environmental carcinogens safrole, 4-aminobiphenyl, and benzo-[a]pyrene. Cancer Res 46:3046-3054.
15. Osborne MR, Beland FA, Harvey RG, Brookes P. 1976. The reaction of (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10- tetrahydrobenzo[a]-pyrene with DNA. Int J Cancer 18:362-368.
16. Poirier MC, Beland FA. 1992. DNA adduct measurement and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment. Chem Res Toxicol 5:749-755.
17. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7:1543-1551.
18. Ross J, Nelson G, Kligerman A, Erexson G, Bryant M, Earley K, Gupta R, Nesnow S. 1990. Formation and persistence of novel benzo-[a]pyrene adducts in rat lung, liver and peripheral blood lymphocyte DNA. Cancer Res 50:5088-5094.
19. Ross JA, Nelson G, Holden K, Kligerman K, Erexson G, Bryant M, Earley K, Beach A, Gupta RC, Nesnow S. 1992. DNA adducts and induction of sister chromatid exchanges in the rat following benzo[b]fluoranthrene administration. Carcinogenesis 13:1731-1734.
20. Rüther U, Müller-Hill B. 1983. Easy identification of cDNA clones. EMBO J 2:1791-1794.
21. Stowers SJ, Anderson MW. 1985. Formation and persistence of benzo-[a]pyrene metabolite-DNA adducts. Environ Health Perspect 62: 31-39.
22. Van Schooten FJ, Hillebrand MJX, Scherer E, den Engelse L, Kriek E. 1991. Immunocytochemical visualization of DNA adducts in mouse tissues and human white blood cells following treatment with benzo[a]pyrene or its diol epoxide: a quantitative approach. Carcinogenesis 12:427-433.