Saccharomyces cerevisiae MGS1 is essential in strains deficient in the RAD6-dependent DNA damage tolerance pathway

EMBO Journal

Volumn 21, Issue 8, 2002, Pages 2019-2029

  Hishida, Takashi ^a   Ohno, Takayuki ^a   Iwasaki, Hiroshi ^b   Shinagawa, Hideo ^a  

^a OSAKA UNIVERSITY   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

DNA replication; Homologous recombination; MGS1 RAD6 epistasis group

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DNA POLYMERASE; FUNGAL DNA; FUNGAL PROTEIN; HELICASE; HYDROXYUREA; MUTANT PROTEIN; POL PROTEIN; PROTEIN MGS1; RAD18 PROTEIN; RAD5 PROTEIN; RAD52 PROTEIN; RAD6 PROTEIN; RESOLVASE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; ESCHERICHIA COLI; FUNGAL GENE; FUNGAL STRAIN; FUNGUS GROWTH; GENE OVEREXPRESSION; GENETIC STABILITY; HOLLIDAY JUNCTION; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVITY;

ADENOSINE TRIPHOSPHATASES; BACTERIAL PROTEINS; CELL CYCLE; DNA DAMAGE; DNA HELICASES; DNA POLYMERASE III; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; EPISTASIS, GENETIC; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FUNGAL PROTEINS; LIGASES; MUTAGENESIS; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TEMPERATURE; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; FUNGI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0037090484     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.8.2019     Document Type: Article

References (55)

1. RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene
2. Primary structure of the RAD52 gene in Saccharomyces cerevisiae
3. Specific complex formation between yeast RAD6 and RAD18 proteins: A potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites
4. Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding and ATP hydrolytic activities
5. Circles: The replication-recombination-chromosome segregation connection
6. The YDp plasmids: A uniform set of vectors bearing versatile gene disruption cassettes for Saccharomyces cerevisiae
7. Mus81-Emel are essential components of a Holliday junction resolvase
8. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics
9. MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway
10. UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae
11. The importance of repairing stalled replication forks
12. Partial suppression of the fission yeast rqhl(-) phenotype by expression of a bacterial Holliday junction resolvase
13. Mutations in the RNA polymerase II transcription machinery suppress the hyper-recombination mutant hprlA of Saccharomyces cerevisiae
14. Involvement of the yeast DNA polymerase δ in DNA repair in vivo
15. The Werner syndrome protein is a DNA helicase
16. DNA recombination: The replication connection
17. A yeast gene, MGS1, encoding a DNA-dependent AAA+ ATPase is required to maintain genome stability
18. MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae
19. Yeast DNA repair protein RAD5 that promotes instability of simple repetitive sequences is a DNA-dependent ATPase
20. Functional interaction between the Werner syndrome protein and DNA polymerase δ
21. A novel protein interacts with the Werner's syndrome gene product physically and functionally
22. Initiation of genetic recombination and recombination-dependent replication
23. DNA damage-induced mutation: Tolerance via translesion synthesis
24. DNA replication meets genetic exchange: Chromosomal damage and its repair by homologous recombination
25. Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants
26. The distribution of the numbers of mutants in bacterial populations
27. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I
28. Genetic interactions between mutants of the 'error-prone' repair group of Saccharomyces cerevisiae and their effect on recombination and mutagenesis
29. Genetic mapping of the Saccharomyces cerevisiae DNA polymerase I gene and characterization of a poll temperature-sensitive mutant altered in DNA primase-polymerase complex stability
30. Nucleotide sequence and characterization of temperature-sensitive poll mutants of Saccharomyces cerevisiae
31. The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism
32. A rapid method for localized mutagenesis of yeast genes
33. Regulatable promoters of Saccharomyces cerevisiae: Comparison of transcriptional activity and their use for heterologous expression
34. The RFC2 gene, encoding the third-largest subunit of the replication factor C complex, is required for an S-phase checkpoint in Saccharomyces
35. SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions?
36. Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae
37. Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3 and rad52 mutations
38. DNA repair genes and proteins of Saccharomyces cerevisiae
39. Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae
40. The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway
41. The Werner syndrome gene: The molecular basis of RecQ helicase-deficiency diseases
42. Rad51 protein involved in repair and recombination in S.cerevisiae is a RecA-like protein
43. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
44. Elevated recombination rates in transcriptionally active DNA
45. The srs2 suppressor of UV sensitivity acts specifically on the RAD5- and MMS2-dependent branch of the RAD6 pathway
46. Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair
47. Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism
48. A plethora of lesion-replicating DNA polymerases
49. The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways
50. Positional cloning of the Werner's syndrome gene
51. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism
52. CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication