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Volumn 14, Issue 1, 2003, Pages 241-250

Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; RAS PROTEIN;

EID: 0037240419     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E02-05-0297     Document Type: Article
Times cited : (31)

References (63)
  • 1
    • 0003455528 scopus 로고
    • Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
    • Ashburner, M. (1989). Drosophila: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
    • (1989) Drosophila: A Laboratory Manual
    • Ashburner, M.1
  • 2
    • 0027299467 scopus 로고
    • Multiple extracellular signals are required for long-term oligodendrocyte survival
    • Barres, B.A., Schmid, R., Sendtner, M., and Raff, M.C. (1993). Multiple extracellular signals are required for long-term oligodendrocyte survival. Development 118, 283-295.
    • (1993) Development , vol.118 , pp. 283-295
    • Barres, B.A.1    Schmid, R.2    Sendtner, M.3    Raff, M.C.4
  • 3
    • 0032582662 scopus 로고    scopus 로고
    • The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
    • Bergmann, A., Agapite, J., McCall, K., and Steller, H. (1998). The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341.
    • (1998) Cell , vol.95 , pp. 331-341
    • Bergmann, A.1    Agapite, J.2    McCall, K.3    Steller, H.4
  • 4
    • 0025060344 scopus 로고
    • Rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster
    • Bier, E., Jan, L.Y., and Jan, Y.N. (1990). rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Genes Dev. 4, 190-203.
    • (1990) Genes Dev. , vol.4 , pp. 190-203
    • Bier, E.1    Jan, L.Y.2    Jan, Y.N.3
  • 5
    • 0032698075 scopus 로고    scopus 로고
    • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    • Bonni, A., Brunet, A., West, A.E., Datta, S.R., Takasu, M.A., and Greenberg, M.E. (1999). Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286, 1358-1362.
    • (1999) Science , vol.286 , pp. 1358-1362
    • Bonni, A.1    Brunet, A.2    West, A.E.3    Datta, S.R.4    Takasu, M.A.5    Greenberg, M.E.6
  • 6
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand, A.H., and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 8
    • 0026643441 scopus 로고
    • mip causes hyperinnervation of a retinotopic map in Drosophila by excessive recruitment of R7 photoreceptor cells
    • Buckles, G.R., Smith, Z.D., and Katz, F.N. (1992). mip causes hyperinnervation of a retinotopic map in Drosophila by excessive recruitment of R7 photoreceptor cells. Neuron 8, 1015-1029.
    • (1992) Neuron , vol.8 , pp. 1015-1029
    • Buckles, G.R.1    Smith, Z.D.2    Katz, F.N.3
  • 9
    • 0033525895 scopus 로고    scopus 로고
    • Sprouty, an intracellular inhibitor of Ras signaling
    • Casci, T., Vinós, J., and Freeman, M. (1999). Sprouty, an intracellular inhibitor of Ras signaling. Cell 96, 655-665.
    • (1999) Cell , vol.96 , pp. 655-665
    • Casci, T.1    Vinós, J.2    Freeman, M.3
  • 10
    • 0033118229 scopus 로고    scopus 로고
    • Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells
    • Chi, S. et al. (1999). Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells. Oncogene 18, 2281-2290.
    • (1999) Oncogene , vol.18 , pp. 2281-2290
    • Chi, S.1
  • 11
    • 0025283961 scopus 로고
    • Developmental cell death: Morphological diversity and multiple mechanisms
    • Clarke, P.G. (1990). Developmental cell death: morphological diversity and multiple mechanisms. Anat. Embryol. (Berl.) 181, 195-213.
    • (1990) Anat. Embryol. (Berl.) , vol.181 , pp. 195-213
    • Clarke, P.G.1
  • 12
    • 0032238275 scopus 로고    scopus 로고
    • Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway
    • Cleghon, V., Feldmann, P., Ghiglione, C., Copeland, T.D., Perrimon, N., Hughes, D.A., and Morrison, D.K. (1998). Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. Mol. Cell 2, 719-727.
    • (1998) Mol. Cell , vol.2 , pp. 719-727
    • Cleghon, V.1    Feldmann, P.2    Ghiglione, C.3    Copeland, T.D.4    Perrimon, N.5    Hughes, D.A.6    Morrison, D.K.7
  • 13
    • 0024379012 scopus 로고
    • Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene
    • Clifford, R.J., and Schupbach, T. (1989). Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene. Genetics 123, 771-87.
    • (1989) Genetics , vol.123 , pp. 771-787
    • Clifford, R.J.1    Schupbach, T.2
  • 14
    • 0029815737 scopus 로고    scopus 로고
    • Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: A case study of the mushroom body miniature gene (mbm)
    • de Belle, J.S., and Heisenberg, M. (1996). Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: a case study of the mushroom body miniature gene (mbm). Proc. Natl. Acad. Sci. USA 93, 9875-9880.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9875-9880
    • De Belle, J.S.1    Heisenberg, M.2
  • 15
    • 0032981635 scopus 로고    scopus 로고
    • Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein
    • Feldmann, P., Eicher, E.N., Leevers, S.J., Hafen, E., and Hughes, D.A. (1999). Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein. Mol. Cell. Biol. 19, 1928-1937.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1928-1937
    • Feldmann, P.1    Eicher, E.N.2    Leevers, S.J.3    Hafen, E.4    Hughes, D.A.5
  • 16
    • 0034176088 scopus 로고    scopus 로고
    • Modeling human neurodegenerative diseases in Drosophila
    • Fortini, M.E., and Bonini, N.M. (2000). Modeling human neurodegenerative diseases in Drosophila. Trends Genet. 16, 161-167.
    • (2000) Trends Genet. , vol.16 , pp. 161-167
    • Fortini, M.E.1    Bonini, N.M.2
  • 17
    • 0027229556 scopus 로고
    • Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
    • Gale, N.W., Kaplan, S., Lowenstein, E.J., Schlessinger, J., and Bar-Sagi, D. (1993). Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature 363, 88-92.
    • (1993) Nature , vol.363 , pp. 88-92
    • Gale, N.W.1    Kaplan, S.2    Lowenstein, E.J.3    Schlessinger, J.4    Bar-Sagi, D.5
  • 18
    • 0029892754 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase
    • Gardner, A.M., and Johnson, G.L. (1996). Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase. J. Biol. Chem. 271, 14560-14566.
    • (1996) J. Biol. Chem. , vol.271 , pp. 14560-14566
    • Gardner, A.M.1    Johnson, G.L.2
  • 19
    • 0026588783 scopus 로고
    • A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase
    • Gaul, U., Mardon, G., and Rubin, G.M. (1992). A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell 68, 1007-1019.
    • (1992) Cell , vol.68 , pp. 1007-1019
    • Gaul, U.1    Mardon, G.2    Rubin, G.M.3
  • 20
    • 0029855245 scopus 로고    scopus 로고
    • The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm
    • Golembo, M., Raz, E., and Shilo, B.Z. (1996). The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm. Development 122, 3363-3370.
    • (1996) Development , vol.122 , pp. 3363-3370
    • Golembo, M.1    Raz, E.2    Shilo, B.Z.3
  • 22
    • 0018352065 scopus 로고
    • Isolation of anatomical brain mutants of Drosophila by histological means
    • Heisenberg, M., and Bohl, K. (1979). Isolation of anatomical brain mutants of Drosophila by histological means. Z. Naturf. 34, 143-147.
    • (1979) Z. Naturf. , vol.34 , pp. 143-147
    • Heisenberg, M.1    Bohl, K.2
  • 24
    • 0028947685 scopus 로고
    • The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway
    • Hou, X.S., Chou, T.B., Melnick, M.B., and Perrimon, N. (1995). The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. Cell 81, 63-71.
    • (1995) Cell , vol.81 , pp. 63-71
    • Hou, X.S.1    Chou, T.B.2    Melnick, M.B.3    Perrimon, N.4
  • 25
  • 26
    • 85046909683 scopus 로고    scopus 로고
    • Cell death mechanisms in neurodegeneration
    • Jellinger, K.A. (2001). Cell death mechanisms in neurodegeneration. J. Cell. Mol. Med. 5, 1-17.
    • (2001) J. Cell. Mol. Med. , vol.5 , pp. 1-17
    • Jellinger, K.A.1
  • 27
    • 0031964429 scopus 로고    scopus 로고
    • Ectopic expression of activated Rasl induces hyperplastic growth and increased cell death in Drosophila imaginal tissues
    • Karim, F.D., and Rubin, G.M. (1998). Ectopic expression of activated Rasl induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. Development 125, 1-9.
    • (1998) Development , vol.125 , pp. 1-9
    • Karim, F.D.1    Rubin, G.M.2
  • 28
    • 0032971161 scopus 로고    scopus 로고
    • Caspase-independent programmed cell death with necrotic morphology
    • Kitanaka, C., and Kuchino, Y. (1999). Caspase-independent programmed cell death with necrotic morphology. Cell. Death Differ. 6, 508-515.
    • (1999) Cell. Death Differ. , vol.6 , pp. 508-515
    • Kitanaka, C.1    Kuchino, Y.2
  • 29
    • 0030864464 scopus 로고    scopus 로고
    • The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila
    • Kretzschmar D., Hasan G., Sharma S., Heisenberg M., and Benzer S. (1997). The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila. J. Neurosci. 19, 7425-7432.
    • (1997) J. Neurosci. , vol.19 , pp. 7425-7432
    • Kretzschmar, D.1    Hasan, G.2    Sharma, S.3    Heisenberg, M.4    Benzer, S.5
  • 30
    • 0031790686 scopus 로고    scopus 로고
    • Disecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation
    • Kumar, J.P., Tio, M. Hsiung, F., Akopyan, S., Gabay, L., Seger, R., Shilo, B.Z., and Moses, K. (1998). Disecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 125, 3875-3885.
    • (1998) Development , vol.125 , pp. 3875-3885
    • Kumar, J.P.1    Tio, M.2    Hsiung, F.3    Akopyan, S.4    Gabay, L.5    Seger, R.6    Shilo, B.Z.7    Moses, K.8
  • 31
    • 0032582793 scopus 로고    scopus 로고
    • Ras promotes cell survival in Drosophila downregulating hid expression
    • Kurada, P., and White, K. (1998). Ras promotes cell survival in Drosophila downregulating hid expression. Cell 95, 319-329.
    • (1998) Cell , vol.95 , pp. 319-329
    • Kurada, P.1    White, K.2
  • 32
    • 0033606961 scopus 로고    scopus 로고
    • Ras-GTPase activating protein inhibition specifically induces apoptosis of tumor cells
    • Leblanc, V., Delumeau, I., and Tocque, B. (1999). Ras-GTPase activating protein inhibition specifically induces apoptosis of tumor cells. Oncogene 18, 4884-4889.
    • (1999) Oncogene , vol.18 , pp. 4884-4889
    • Leblanc, V.1    Delumeau, I.2    Tocque, B.3
  • 33
    • 0033583242 scopus 로고    scopus 로고
    • Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
    • Lee, A.C. et al. (1999). Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 274, 7936-7940.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7936-7940
    • Lee, A.C.1
  • 34
    • 0032937879 scopus 로고    scopus 로고
    • Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
    • Le-Niculescu, H., Bonfoco, E., Kasuya, Y., Claret, F.X., Green, D.R., and Karin, M. (1999). Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol. Cell. Biol. 19, 751-763.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 751-763
    • Le-Niculescu, H.1    Bonfoco, E.2    Kasuya, Y.3    Claret, F.X.4    Green, D.R.5    Karin, M.6
  • 35
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin, A.W., Barradas, M., Stone, J.C., van Aelst, L., Serrano, M., and Lowe, S.W. (1998). Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12, 3008-3019.
    • (1998) Genes Dev. , vol.12 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    Van Aelst, L.4    Serrano, M.5    Lowe, S.W.6
  • 36
    • 0033571906 scopus 로고    scopus 로고
    • Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway
    • Mazzoni, I.E., Said, F.A., Aloyz, R., Miller, F.D., and Kaplan, D. (1999). Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway. J. Neurosci. 19, 9716-9727.
    • (1999) J. Neurosci. , vol.19 , pp. 9716-9727
    • Mazzoni, I.E.1    Said, F.A.2    Aloyz, R.3    Miller, F.D.4    Kaplan, D.5
  • 37
    • 0032488053 scopus 로고    scopus 로고
    • A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system
    • Melzig, J., Rein, K.H., Schafer, U., Pfister, H., Jackle, H., Heisenberg, M., and Raabe, T. (1998). A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system. Curr. Biol. 22, 1223-1226.
    • (1998) Curr. Biol. , vol.22 , pp. 1223-1226
    • Melzig, J.1    Rein, K.H.2    Schafer, U.3    Pfister, H.4    Jackle, H.5    Heisenberg, M.6    Raabe, T.7
  • 38
    • 0027468233 scopus 로고
    • A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange
    • Olivier, J.P., Raabe, T., Henkemeyer, M., Dickson, B., Mbamalu, G., Margolis, B., Schlessinger, J., Hafen, E., and Pawson, T. (1993). A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73, 179-191.
    • (1993) Sos. Cell , vol.73 , pp. 179-191
    • Olivier, J.P.1    Raabe, T.2    Henkemeyer, M.3    Dickson, B.4    Mbamalu, G.5    Margolis, B.6    Schlessinger, J.7    Hafen, E.8    Pawson, T.9
  • 39
    • 0029000678 scopus 로고
    • Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila
    • Raabe, T., Olivier, J.P., Dickson, B., Liu, X., Gish, G.D., Pawson, T., and Hafen, E. (1995). Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of. Drosophila. EMBO J. 14, 2509-2518.
    • (1995) EMBO J. , vol.14 , pp. 2509-2518
    • Raabe, T.1    Olivier, J.P.2    Dickson, B.3    Liu, X.4    Gish, G.D.5    Pawson, T.6    Hafen, E.7
  • 40
    • 0027373764 scopus 로고
    • Programmed cell death and the control of cell survival: Lessons from the nervous system
    • Raff, M.C., Barres, B.A., Burne, J.F., Coles, H.S., Ishizaki, Y., and Jacobson, M.D. (1993). Programmed cell death and the control of cell survival: lessons from the nervous system. Science 262, 695-700.
    • (1993) Science , vol.262 , pp. 695-700
    • Raff, M.C.1    Barres, B.A.2    Burne, J.F.3    Coles, H.S.4    Ishizaki, Y.5    Jacobson, M.D.6
  • 41
    • 0034104590 scopus 로고    scopus 로고
    • The Ras branch of small GTPases: Ras family members don't fall far from the tree
    • Reuther, G.W., and Der, C.J. (2000). The Ras branch of small GTPases: Ras family members don't fall far from the tree. Curr. Opin. Cell Biol. 12, 157-165.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 157-165
    • Reuther, G.W.1    Der, C.J.2
  • 42
    • 52649114611 scopus 로고
    • The use of lead citrate at high pH as an electronopaque stain in electron microscopy
    • Reynolds, E.S. (1963). The use of lead citrate at high pH as an electronopaque stain in electron microscopy. J. Cell Biol. 17, 208-212.
    • (1963) J. Cell Biol. , vol.17 , pp. 208-212
    • Reynolds, E.S.1
  • 43
    • 0025744938 scopus 로고
    • Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development
    • Robinow, S., and White, K. (1988). Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J. Neurobiol. 22, 443-461.
    • (1988) J. Neurobiol. , vol.22 , pp. 443-461
    • Robinow, S.1    White, K.2
  • 44
    • 0023880221 scopus 로고
    • The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages
    • Robinow, S., and White, K. (1991). The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages. Dev. Biol. 126, 294-303.
    • (1991) Dev. Biol. , vol.126 , pp. 294-303
    • Robinow, S.1    White, K.2
  • 45
    • 0031883684 scopus 로고    scopus 로고
    • Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: Clonal analysis and morphology of imaginal discs
    • Roch, F. et al. (1998). Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs. Mol. Gen. Genet. 257, 103-112.
    • (1998) Mol. Gen. Genet. , vol.257 , pp. 103-112
    • Roch, F.1
  • 46
    • 0029861146 scopus 로고    scopus 로고
    • A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
    • Rorth, P. (1996). A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc. Natl. Acad. Sci. USA 93, 12418-12422.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 12418-12422
    • Rorth, P.1
  • 47
    • 0020615650 scopus 로고
    • Glial membrane specializations and the compartmentalization of the lamina ganglionaris of the housefly
    • Saint Marie, R.L., and Carlson, S.D. (1983a). Glial membrane specializations and the compartmentalization of the lamina ganglionaris of the housefly. J. Neurocytol. 12, 243-275.
    • (1983) J. Neurocytol. , vol.12 , pp. 243-275
    • Saint Marie, R.L.1    Carlson, S.D.2
  • 48
    • 0020744404 scopus 로고
    • The fine structure of glia in the lamina ganglionaris of the housefly, Musca domestica
    • Saint Marie, R.L., and Carlson, S.D. (1983b). The fine structure of glia in the lamina ganglionaris of the housefly, Musca domestica. J. Neurocytol. 12, 213-241.
    • (1983) J. Neurocytol. , vol.12 , pp. 213-241
    • Saint Marie, R.L.1    Carlson, S.D.2
  • 50
    • 0031850872 scopus 로고    scopus 로고
    • Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway
    • Sawamoto, K., Taguchi, A., Hirota, Y., Yamada, C., Jin, M., and Okano, H. (1998). Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway. Cell Death Differ. 5, 262-270.
    • (1998) Cell Death Differ. , vol.5 , pp. 262-270
    • Sawamoto, K.1    Taguchi, A.2    Hirota, Y.3    Yamada, C.4    Jin, M.5    Okano, H.6
  • 51
    • 0023057627 scopus 로고
    • Alternative 5′ exons and tissue-specific expression of the Drosophila EGF receptor homolog transcripts
    • Schejter, E.D., Segal, D., Glazer, L., and Shilo, B.Z. (1986). Alternative 5′ exons and tissue-specific expression of the Drosophila EGF receptor homolog transcripts. Cell 46, 1091-1101.
    • (1986) Cell , vol.46 , pp. 1091-1101
    • Schejter, E.D.1    Segal, D.2    Glazer, L.3    Shilo, B.Z.4
  • 52
    • 0029100254 scopus 로고
    • Inhibition of Drosophila EGF receptor activation by the secreted protein Argos
    • Schweitzer, R., Howes, R., Smith, R., Shilo, B.Z., and Freeman, M. (1995). Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376, 699-702.
    • (1995) Nature , vol.376 , pp. 699-702
    • Schweitzer, R.1    Howes, R.2    Smith, R.3    Shilo, B.Z.4    Freeman, M.5
  • 53
    • 0022726823 scopus 로고
    • Tissue localization of Drosophila melanogaster ras transcripts during development
    • Segal, D., and Shilo, B.Z. (1986). Tissue localization of Drosophila melanogaster ras transcripts during development. Mol. Cell. Biol. 6, 2241-2248.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 2241-2248
    • Segal, D.1    Shilo, B.Z.2
  • 54
    • 0027404990 scopus 로고
    • An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro
    • Simon, M.A., Dodson, G.S., and Rubin, G.M. (1993). An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro. Cell 73, 169-177.
    • (1993) Cell , vol.73 , pp. 169-177
    • Simon, M.A.1    Dodson, G.S.2    Rubin, G.M.3
  • 55
    • 0027176294 scopus 로고
    • The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway
    • Sturtevant, M.A., Roark, M., and Bier, E. (1993). The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev. 7, 961-973.
    • (1993) Genes Dev. , vol.7 , pp. 961-973
    • Sturtevant, M.A.1    Roark, M.2    Bier, E.3
  • 56
    • 0033081054 scopus 로고    scopus 로고
    • TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock
    • Suri, V., Lanjuin, A., and Rosbash, M. (1999). TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock. EMBO J. 18, 675-686.
    • (1999) EMBO J. , vol.18 , pp. 675-686
    • Suri, V.1    Lanjuin, A.2    Rosbash, M.3
  • 57
    • 0033529031 scopus 로고    scopus 로고
    • Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport
    • Torroja, L., Chu, H., Kotovsky, I., and White, K. (1999). Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport. Curr. Biol. 9, 489-492.
    • (1999) Curr. Biol. , vol.9 , pp. 489-492
    • Torroja, L.1    Chu, H.2    Kotovsky, I.3    White, K.4
  • 58
    • 0030899808 scopus 로고    scopus 로고
    • Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap
    • van der Geer, P., Henkemeyer, M., Jacks, T., and Pawson, T. (1997). Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap. Mol. Cell. Biol. 17, 1840-1847.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1840-1847
    • Van der Geer, P.1    Henkemeyer, M.2    Jacks, T.3    Pawson, T.4
  • 59
    • 0031785812 scopus 로고    scopus 로고
    • Proteolytic cleavage of ras GTPase-activating protein during apoptosis
    • Wen, L.P., Madani, K., Martin, G.A., and Rosen, G.D. (1998). Proteolytic cleavage of ras GTPase-activating protein during apoptosis. Cell Death Differ. 5, 729-734.
    • (1998) Cell Death Differ. , vol.5 , pp. 729-734
    • Wen, L.P.1    Madani, K.2    Martin, G.A.3    Rosen, G.D.4
  • 61
    • 0024728688 scopus 로고
    • P-element-mediated enhancer detection: An efficient method for isolating and characterizing developmentally regulated genes in Drosophila
    • Wilson, C., Pearson, R.K., Bellen, H.J., O'Kane, C.J., Grossniklaus, U., and Gehring, W.J. (1989). P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila. Genes Dev. 9, 1301-1313.
    • (1989) Genes Dev. , vol.9 , pp. 1301-1313
    • Wilson, C.1    Pearson, R.K.2    Bellen, H.J.3    O'Kane, C.J.4    Grossniklaus, U.5    Gehring, W.J.6
  • 62
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAPK kinases on apoptosis
    • Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J., and Greenberg, M.E. (1995). Opposing effects of ERK and JNK-p38 MAPK kinases on apoptosis. Science 270, 1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 63
    • 0031044540 scopus 로고    scopus 로고
    • The neurotrophic action and signaling of epidermal growth factor
    • Yamada, M., Ikeuchi, T., and Hatanaka, H. (1997). The neurotrophic action and signaling of epidermal growth factor. Prog. Neurobiol. 51, 19 -37.
    • (1997) Prog. Neurobiol. , vol.51 , pp. 19-37
    • Yamada, M.1    Ikeuchi, T.2    Hatanaka, H.3


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