High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients

British Journal of Haematology

Volumn 111, Issue 3, 2000, Pages 774-781

  Ljungman, P ^a   Wang, F Z ^a,b   Clark, D A ^c   Emery, V C ^c   Remberger, M ^a   Ringden O ^a   Linde, A ^a,b,d  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Allogeneic stem cell transplantation; Encephalitis; Herpesvirus; HHV 6; qPCR

Indexed keywords

ACICLOVIR; IMMUNOGLOBULIN; VALACICLOVIR; VIRUS DNA;

ADOLESCENT; ADULT; ARTICLE; CANCER PATIENT; CHILD; CLINICAL FEATURE; CORRELATION FUNCTION; FEMALE; HLA MATCHING; HUMAN; HUMAN HERPESVIRUS 6; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGRESSION ANALYSIS; SIBLING; STEM CELL TRANSPLANTATION; THROMBOCYTE; TREATMENT OUTCOME; VIRUS ENCEPHALITIS; VIRUS HEPATITIS; VIRUS INFECTION; VIRUS LOAD;

ACYCLOVIR; ADOLESCENT; ADULT; ANTIVIRAL AGENTS; BLOOD PLATELETS; BONE MARROW TRANSPLANTATION; CENTRAL NERVOUS SYSTEM DISEASES; CHILD; CHILD, PRESCHOOL; CYTOMEGALOVIRUS; DNA, VIRAL; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEPATITIS; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 6, HUMAN; HISTOCOMPATIBILITY TESTING; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; LEUKOCYTES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PLATELET TRANSFUSION; POLYMERASE CHAIN REACTION; POSTOPERATIVE PERIOD; PROSPECTIVE STUDIES; TRANSPLANTATION, HOMOLOGOUS; VIRAL LOAD;

EID: 0034490457     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02422.x     Document Type: Article

References (28)

1. Efficacy of immune globulin in preventing complications of bone marrow transplantation: A meta-analysis
2. Fatal herpesvirus 6 encephalitis after unrelated bone marrow transplant
3. Human herpesvirus 6
4. Human herpesvirus 6 (HHV-6) isolation from bone marrow: HHV-6-associated bone marrow suppression in bone marrow transplant patients
5. Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation
6. Quantification of human herpesvirus 6 in immunocompetent persons and postmortem tissues from AIDS patients by PCR
7. Human herpesvirus 6 infections after bone marrow transplantation: Clinical and virologic manifestations
8. Interrelationships among quantity of human cytomegalovirus (HCMV) DNA in blood donor-recipient serostatus, and administration of methylprednisolone as risk factors for HCMV disease following liver transplantation
9. Brief report: Fatal encephalitis due to variant B human herpesvirus-6 infection in a bone marrow-transplant recipient
10. Longitudinal fluctuations in cytomegalovirus load in bone marrow transplant patients: Relationship between peak virus load, donor/recipient serostatus acute GVHD and CMV clisease
11. Faster neutrophil and platelet engraftment, but no differences in acute GVHD or survival, using peripheral blood stem cells from related and unrelated donors, compared to bone marrow
12. Longitudinal study of human herpesvirus 6 infection in organ transplant recipients
13. Does high-dose intravenous immune globulin treatment after bone marrow transplantation increase mortality in veno-occlusive disease of the liver?
14. Human herpesvirus-6 infection after liver transplantation
15. Use of a semi-quantitative PCR for cytomegalovirus DNA as a basis for pre-emptive antiviral therapy in allogeneic bone marrow transplant patients
16. Results of different strategies for reducing cytomegalovirus-associated mortality in allogeneic stem cell transplant recipients
17. Monitoring of human herpesviruses after allogeneic peripheral blood stem cell transplantation and bone marrow transplantation
18. Human herpes virus-6 encephalitis after bone marrow transplantation: Successful treatment with ganciclovir
19. Human herpesvirus-6 meningoencephalitis in a recipient of an unrelated allogeneic bone marrow transplantation
20. Prevention of graft-versus-host disease with T-cell depletion or cyclosporin and methotrexate. A randomized trial in adult leukemic marrow recipients
21. A randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia: A report from the Nordic Bone Marrow Transplantation Group
22. Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr virus-related lymphoproliferation
23. Immunomodulatory and antimicrobial efficacy of intravenous immunoglobulin in bone marrow transplantation
24. Bone marrow transplantation
25. Human herpesvirus-6 encephalitis after bone marrow transplantation: Magnetic resonance imaging could identify the involved sites of encephalitis
26. Lymphotropic herpesviruses in allogeneic bone marrow transplantation
27. Human herpesvirus 6 DNA in cerebrospinal fluid specimens from allogeneic bone marrow transplant patients: Does it have clinical significance?
28. Identification of human herpesvirus-6 as a causal agent for exanthem subitum