Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lymphocyte-associated antigen 4, and programmed cell death 1 in primary Sjögren's syndrome

Arthritis and Rheumatism

Volumn 48, Issue 1, 2003, Pages 174-185

  Bolstad, Anne Isine ^a,b   Eiken, Hans Geir ^b   Rosenlund, Benedikte ^b   Alarcón Riquelme, Marta E ^c   Jonsson, Roland ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS LIGAND;

ADULT; AGED; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL DEATH; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION REGULATION; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MESSENGER RNA SYNTHESIS; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY GLAND; SINGLE NUCLEOTIDE POLYMORPHISM; SJOEGREN SYNDROME; TISSUE DISTRIBUTION;

ADULT; AGED; ANTIGENS, CD; ANTIGENS, CD95; ANTIGENS, DIFFERENTIATION; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; FAS LIGAND PROTEIN; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOCONJUGATES; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SALIVARY GLANDS; SJOGREN'S SYNDROME;

EID: 0037231555     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10734     Document Type: Article

References (56)

1. Jonsson R, Brokstad KA. Sjögren's syndrome. In: Austen KF, Frank MM, Atkinson JP, Cantor HI, editors. Samter's immunologic diseases. Philadelphia: Lippincott, Williams & Wilkins; 2001. p. 495-504.
2. Buyon JP, Hiebert R, Copel J, Craft J, Friedman D, Katholi M, et al. Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J Am Coll Cardiol 1998;31:1658-66.
3. Chan EK, Di Donato F, Hamel JC, Tseng CE, Buyon JP. 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart. J Exp Med 1995;182:983-92.
4. Halse A, Harley JB, Kroneld U, Jonsson R. Ro/SS-A-reactive B lymphocytes in salivary glands and peripheral blood of patients with Sjögren's syndrome. Clin Exp Immunol 1999;115:203-7.
5. Nakken B, Jonsson R, Bolstad AI. Polymorphisms of the Ro52 gene associated with anti-Ro 52-kd autoantibodies in patients with primary Sjögren's syndrome. Arthritis Rheum 2001;44:638-46.
6. Humphreys-Beher MG, Brayer J, Yamachika S, Peck AB, Jonsson R. An alternative perspective to the immune response in autoimmune exocrinopathy: induction of functional quiescence rather than destructive autoaggression. Scand J Immunol 1999;49:7-10.
7. Bacman S, Sterin-Borda L, Camusso JJ, Arana R, Hubscher O, Borda E. Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren's syndrome. Clin Exp Immunol 1996;104:454-9.
8. Sharma K, Wang RX, Zhang LY, Yin DL, Luo XY, Solomon JC, et al. Death the Fas way: regulation and pathophysiology of CD95 and its ligand. Pharmacol Ther 2000;88:333-47.
9. Mullauer L, Gruber P, Sebinger D, Buch J, Wohlfart S, Chott A. Mutations in apoptosis genes: a pathogenetic factor for human disease. Mutat Res 2001;488:211-31.
10. Manganelli P, Quaini F, Andreoli AM, Lagrasta C, Pilato FP, Zuccarelli A, et al. Quantitative analysis of apoptosis and bcl-2 in Sjögren's syndrome. J Rheumatol 1997;24:1552-7.
11. Matsumura R, Umemiya K, Kagami M, Tomioka H, Tanabe E, Sugiyama T, et al. Glandular and extraglandular expression of the Fas-Fas ligand and apoptosis in patients with Sjögren's syndrome. Clin Exp Rheumatol 1998;16:561-8.
12. Bolstad Al, Jonsson R. The role of apoptosis in Sjögren's syndrome. Ann Med Interne (Paris) 1998;149:25-9.
13. Nishimura H, Honjo T. PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol 2001;22:265-8.
14. Sinclair NR. Why so many coinhibitory receptors? Scand J Immunol 1999;50:10-3.
15. Waterhouse P, Marengere LE, Mittrucker HW, Mak TW. CTLA-4, a negative regulator of T-lymphocyte activation. Immunol Rev 1996;153:183-207.
16. Nishimura H, Minato N, Nakano T, Honjo T. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol 1998;10:1563-72.
17. Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999;11:141-51.
18. Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 2001;291:319-22.
19. Kristiansen OP, Larsen ZM, Pociot F. CTLA-4 in autoimmune diseases: a general susceptibility gene to autoimmunity? Genes Immun 2000;1:170-84.
20. Wang XB, Zheng CY, Giscombe R, Lefvert AK. Regulation of surface and intracellular expression of CTLA-4 on human peripheral T cells. Scand J Immunol 2001;54:453-8.
21. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541-7.
22. Kaufman KA, Bowen JA, Tsai AF, Bluestone JA, Hunt JS, Ober C. The CTLA-4 gene is expressed in placental fibroblasts. Mol Hum Reprod 1999;5:84-7.
23. Johansson ACM, Nakken B, Sundler M, Lindqvist AK, Johannesson M, Alarcon-Riquelme M, et al. The genetic control of sialadenitis versus arthritis in a NOD.Q × B10.Q F2 cross. Eur J Immunol 2002;32:243-50.
24. Dente L, Pizza MG, Metspalu A, Cortese R. Structure and expression of the genes coding for human alpha 1-acid glycoprotein. EMBO J 1987;6:2289-96.
25. Merritt CM, Board PG. Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene. Gene 1988;66:97-106.
26. Craig AG, Mullins JJ, McTurk P, Brammar WJ. A mouse gene family associated with a major submaxillary-gland glycoprotein. Biochem J 1985;225:657-63.
27. Libert C, Brouckaert P, Fiers W. Protection by alpha 1-acid glycoprotein against tumor necrosis factor-induced lethality. J Exp Med 1994;180:1571-5.
28. Hochepied T, Van Molle W, Berger FG, Baumann H, Libert C. Involvement of the acute phase protein alpha 1-acid glycoprotein in nonspecific resistance to a lethal gram-negative infection. J Biol Chem 2000;275:14903-9.
29. Yuasa I, Umetsu K, Vogt U, Nakamura H, Nanba E, Tamaki N, et al. Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S. Hum Genet 1997;99:393-8.
30. Tzioufas AG, Hantoumi I, Polihronis M, Xanthou G, Moutsopoulos HM. Autoantibodies to La/SSB in patients with primary Sjögren's syndrome (primary SS) are associated with upregulation of La/SSB mRNA in minor salivary gland biopsies (MSGs). J Autoimmun 1999;13:429-34.
31. Kolkowski EC, Reth P, Pelusa F, Bosch J, Pujol-Borrell R, Coll J, et al. Th1 predominance and perforin expression in minor salivary glands from patients with primary Sjögren's syndrome. J Autoimmun 1999;13:155-62.
32. Bachmann M, Hilker M, Grolz D, Tellmann G, Hake U, Kater L, et al. Different La/SS-B mRNA isoforms are expressed in salivary gland tissue of patients with primary Sjögren's syndrome. J Autoimmun 1996;9:757-66.
33. Fox PC, Brennan M, Di Sun P. Cytokine expression in human labial minor salivary gland epithelial cells in health and disease. Arch Oral Biol 1999;44 Suppl 1:S49-52.
34. Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Fujimura T, et al. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 1996;39:1376-84.
35. Gibson UE, Heid CA, Williams PM. A novel method for real time quantitative RT-PCR. Genome Res 1996;6:995-1001.
36. Heid CA, Stevens J, Livak KJ, Williams PM. Real time quantitative PCR. Genome Res 1996;6:986-94.
37. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554-8.
38. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577-80.
39. Skarstein K, Nerland AH, Eidsheim M, Mountz JD, Jonsson R. Lymphoid cell accumulation in salivary glands of autoimmune MRL mice can be due to impaired apoptosis. Scand J Immunol 1997;46:373-8.
40. Ohlsson M, Skarstein K, Bolstad AI, Johannessen AC, Jonsson R. Fas-induced apoptosis is a rare event in Sjögren's syndrome. Lab Invest 2001;81:95-105.
41. Ohlsson M, Szodoray P, Loro LL, Johannessen AC, Jonsson R. CD40, CD154, bax and bcl-2 expression in Sjögren's syndrome salivary glands: a putative anti-apoptotic role during its effector phases. Scand J Immunol 2002;56:561-71.
42. Bolstad AI, Wargelius A, Nakken B, Haga HJ, Jonsson R. Fas and Fas ligand gene polymorphisms in primary Sjögren's syndrome. J Rheumatol 2000;27:2397-405.
43. Pruijn GJ, Simons FH, van Venrooij WJ. Intracellular localization and nucleocytoplasmic transport of Ro RNP components. Eur J Cell Biol 1997;74:123-32.
44. Ohlsson M, Jonsson R, Brokstad K. Subcellular redistribution and surface exposure of the Ro52, Ro60 and La48 autoantigen during apoptosis in human ductal epithelial cells: a possible mechanism in the pathogenesis of Sjögren's syndrome. Scand J Immunol 2002;56: 456-69.
45. Frank MB, McCubbin VR, Heldermon C. Expression and DNA binding of the human 52 kDa Ro/SSA autoantigen. Biochem J 1995;305:359-62.
46. Buyon JP, Tseng CE, Di Donato F, Rashbaum W, Morris A, Chan EK. Cardiac expression of 52β, an alternative transcript of the congenital heart block-associated 52-kd SS-A/Ro autoantigen, is maximal during fetal development. Arthritis Rheum 1997;40: 655-60.
47. Smeenk RJ. Antinuclear antibodies: cause of disease or caused by disease? Rheumatology (Oxford) 2000;39:581-4.
48. Kapsogeorgou EK, Moutsopoulos HM, Manoussakis MN. Functional expression of a costimulatory B7.2 (CD86) protein on human salivary gland epithelial cells that interacts with the CD28 receptor, but has reduced binding to CTLA4. J Immunol 2001;166:3107-13.
49. Shinohara T, Taniwaki M, Ishida Y, Kawaichi M, Honjo T. Structure and chromosomal localization of the human PD-1 gene (PDCD1). Genomics 1994;23:704-6.
50. Finger LR, Pu J, Wasserman R, Vibhakar R, Louie E, Hardy RR, et al. The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors. Gene 1997;197:177-87.
51. Magnusson V, Lindqvist AK, Castillejo-Lopez C, Kristjansdottir H, Steinsson K, Grondal G, et al. Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus. Genomics 2000;70:307-14.
52. Lindqvist AK, Steinsson K, Johanneson B, Kristjansdottir H, Arnasson A, Grondal G, et al. A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q. J Autoimmun 2000;14:169-78.
53. Prokunina L, Castillejo-Löpez C, Öberg F, Gunnarsson I, Berg L, Magnusson V, et al. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat Gene 2002;32:666-9.
54. Orteu CH, Poulter LW, Rustin MH, Sabin CA, Salmon M, Akbar AN. The role of apoptosis in the resolution of T cell-mediated cutaneous inflammation. J Immunol 1998;161:1619-29.
55. Pilling D, Akbar AN, Girdlestone J, Orteu CH, Borthwick NJ, Amft N, et al. Interferon-beta mediates stromal cell rescue of T cells from apoptosis. Eur J Immunol 1999;29:1041-50.
56. Olofsson P, Nordquist N, Vingsbo-Lundberg C, Larsson A, Falkenberg C, Pettersson U, et al. Genetic links between the acute-phase response and arthritis development in rats. Arthritis Rheum 2002;46:259-68.