Ro/SS-A-reactive B lymphocytes in salivary glands and peripheral blood of patients with Sjogren's syndrome

Clinical and Experimental Immunology

Volumn 115, Issue 1, 1999, Pages 203-207

  Halse, Anne Kristine ^c   Harley, J B ^a   Kroneld, U ^b   Jonsson, R ^d  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF BERGEN   (Norway)

^d NONE

Author keywords

Labial salivary glands; Peripheral blood; Ro SS A; Sjogren's syndrome

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BLOOD; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SALIVARY GLAND; SJOEGREN SYNDROME;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODY FORMATION; ANTIBODY-PRODUCING CELLS; B-LYMPHOCYTES; CATTLE; CELL COUNT; FEMALE; HUMANS; LYMPHOCYTE COUNT; SALIVARY GLANDS, MINOR; SJOGREN'S SYNDROME;

EID: 0032916718     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00778.x     Document Type: Article

References (32)

1. 1 Maddison PJ. Autoantibodies in Sjögren's syndrome: their origins and pathological consequences. In: Isenberg DA, Horsfall AC, eds. Autoimmune diseases: focus on Sjögren's syndrome. London: Bios Scientific Publishers, 1994:89-100.
2. 2 Vitali C, Bombardieri S, Moutsopoulos HM et al. Preliminary criteria for the classification of Sjögren's syndrome. Arthritis Rheum 1993; 36:340-7.
3. 3 Tan EM. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 1989; 44:93-106.
4. 4 Harley JB, Alexander EL, Bias WB et al. Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's syndrome. Arthritis Rheum 1986; 29:196-206.
5. 5 Pease CT, Charles PJ, Shattles W, Markwick J, Maini RN. Serological and immunogenetic markers of extraglandular primary Sjögren's syndrome. Br J Rheumatol 1993; 32:574-7.
6. 6 Wolin SL, Steitz JA. The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs. Proc Natl Acad Sci USA 1984; 81:1996-2000.
7. 7 Ben-Chetrit E, Chan EKL, Sullivan KF, Tan EM. A 52-kD protein is a novel component of the SS-A/Ro antigenic particle. J Exp Med 1988; 167:1560-71.
8. 8 Reichlin M, Rader M, Harley JB. Autoimmune response to the Ro/SSA particle is directed to the human antigen. Clin Exp Immunol 1989; 76:373-7.
9. 9 Cxerkinsky CC, Nilsson L-Å, Nygren H, Ouchterlony Ö, Tarkowski A. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J Immunol Methods 1983; 65:109-21.
10. 10 Horsfall AC, Rose LM, Maini RN. Autoantibody synthesis in salivary glands of Sjögren's syndrome patients. J Autoimmun 1989; 2:559-68.
11. 11 Ben-Chetrit E, Fischel R, Rubinow A. Anti-SSA/Ro and anti-SSB/La antibodies in serum and saliva of patients with Sjögren's syndrome. Clin Rheumatol 1993; 12:471-4.
12. 12 Wahren M, Skarstein K, Blange I, Pettersson I, Jonsson R. MRL/lpr mice produce anti-Ro 52 000 MW antibodies: detection, analysis of specificity and site of production. Immunology 1994; 83:9-15.
13. 13 Greenspan JS, Daniels TE, Talal N, Sylvester RA. The histopathology of Sjögren's syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol 1974; 37:217-29.
14. 14 Daniels TE. Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases. Arthritis Rheum 1984; 27:147-56.
15. 15 Yamagata H, Harley JB, Reichlin M. Molecular properties of the Ro/ SSA antigen and enzyme-linked immunosorbent assay for quantitation of antibody. J Clin Invest 1984; 74:625-33.
16. 16 Frangakis MV, Koopman WJ, Kiyono H, Michalek SM, McGhee JR. An enzymatic method for preparation of dissociated murine Peyer's patch cells enriched for macrophages. J Immunol Methods 1982; 48:33-44.
17. 17 Jonsson R, Pitts A, Lue C, Gay S, Mestecky J. Immunoglobulin isotype distribution of locally produced autoantibodies to collagen type I in adult periodontitis. J Clin Periodontol 1991; 18:703-7.
18. 18 Thorsby E, Bratlie A. A rapid method for preparation of pure lymphocyte suspensions. In: Terasaki PI, ed. Histocompatibility testing. Copenhagen: Munksgaard, 1970:655-6.
19. 19 Ting A, Morris PJ. A technique for lymphocyte preparation from stored heparinized blood. Vox Sang 1971; 20:561-3.
20. 20 Rönnelid J, Lysholm J, Engström-Laurent A, Klareskog L, Heyman B. Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid. Evidence for an HLA-DR4-restricted IgG response. Arthritis Rheum 1994; 37:1023-9.
21. 21 Tarkowski A, Klareskog L, Carlsten H, Herberts P, Koopman WJ. Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis. Arthritis Rheum 1989; 32:1087-92.
22. 22 Björkland A, Lööf L, Mendel-Hartvig I, Tötterman TH. Primary biliary cirrhosis. High proportions of B cells in blood and liver tissue produce anti-mitochondrial antibodies of several Ig classes. J Immunol 1994; 153:2750-7.
23. 23 Olsson T, Baig S, Höjeberg B, Link H. Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis. Ann Neurol 1990; 27:132-6.
24. 24 Sun J-B, Olsson T, Wang W-Z et al. Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur J Immunol 1991; 21:1461-8.
25. 25 Link H, Olsson O, Sun J et al. Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls. J Clin Invest 1991; 87:2191-6.
26. 26 Halse A-K, Wahren M, Jonsson R. Peripheral blood in Sjögren's syndrome does not contain increased levels of T lymphocytes reactive with the recombinant Ro/SS-A 52 kD and La/SS-B 48 kD autoantigens. Autoimmunity 1996; 23:25-34.
27. 27 Namekawa T, Kuroda K, Kato T et al. Identification of Ro (SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjögren's syndrome. J Rheumatol 1995; 22:2092-9.
28. 28 Horsfall AC, Venables PJW, Taylor PV, Maini RN. Ro and La antigens and maternal anti-La idiotype on the surface of myocardial fibres in congenital heart block. J Autoimmun 1991; 4:165-76.
29. 29 Penner E, Reichlin M. Primary biliary cirrhosis associated with Sjö gren's syndrome: evidence for circulating and tissue-deposited Ro/anti-Ro immune complexes. Arthritis Rheum 1982; 25:1250-3.
30. 30 Reichlin M. Molecular definition of the Ro (SSA) particle(s): a frequent target of autoimmunity in systemic lupus erythematosus and Sjogren's syndrome. Br J Rheumatol 1991; 30 (Suppl. 1):58-62.
31. 31 Tengnér P, Halse A-K, Haga H-J, Jonsson R, Wahren-Herlenius M. Detection of anti-Ro/SSA and anti-La/SSB autoantibody producing cells in salivary glands from patients with Sjögren's syndrome. Arthritis Rheum 1998; 41, in press.
32. 32 Halse A-K, Wahren-Herlenius M, Jonsson R. Ro/SS-A and La/SS-B reactive B lymphocytes in peripheral blood of patients with Sjögren's syndrome. Clin Exp Immunol 1999; 115:209-14.