Positron-emission tomography monitoring of anti-glioblastoma HSV-1-tk gene therapy

Gene Therapy and Regulation

Volumn 2, Issue 1, 2003, Pages 49-57

  Jacobs, Andreas H ^a   Winkeler, Alexandra ^a   Dittmar, Claus ^a   Vollmar, Stefan ^a   Wienhard, Klaus ^a   Reszka, Regina ^a   Voges, Jurgen ^a   Heiss, Wolf Dieter ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

FIAU; Functional imaging; Gene therapy; Glioblastoma; HSV 1 thymidine kinase; Molecular imaging

Indexed keywords

2' FLUORO 2' DEOXY 1 BETA DEXTRO ARABINOFURANOSYL 5 IODOURACIL I 124; CARBON 11; DAC 30; DMRIE; DNA; FLUORINE 18; FLUORODEOXYGLUCOSE F 18; GANCICLOVIR; IODINE 124; LIPID; LIPOSOME; METHIONINE; RADIOPHARMACEUTICAL AGENT; THYMIDINE DERIVATIVE; THYMIDINE KINASE; UNCLASSIFIED DRUG; URACIL DERIVATIVE; VIRUS VECTOR;

ADULT; AGED; BRAIN TUMOR; CLINICAL ARTICLE; CLINICAL TRIAL; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; GLIOBLASTOMA; HERPES SIMPLEX VIRUS 1; HUMAN; IMAGING SYSTEM; NONHUMAN; PATIENT MONITORING; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PLASMID; POSITRON EMISSION TOMOGRAPHY; REVIEW; TRANSGENE; VIRAL GENE THERAPY;

HERPES; HUMAN HERPESVIRUS 1;

EID: 0037224870     PISSN: 13889532     EISSN: None     Source Type: Journal    
DOI: 10.1163/156855803762295422     Document Type: Review

References (29)

1. Blasberg, R.G. and Tjuvajev, J.G. (2002). Molecular imaging: A nuclear medicine-based perspective. Molecular Imaging, in press.
2. Culver, K.W., Ram, Z., Wallbridge, S., Ishii, H., Oldfield, E.H. and Blaese, R.M. (1992). In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science, 256: 1550-1552.
3. De Vries, E.F., Buursma, A.R., Hospers, G.A., Mulder, N.H. and Vaalburg, W. (2002). Scintigraphic imaging of HSVtk gene therapy. Curr. Pharm. Des., 8: 1435-1450.
4. Eck, S.L., Alavi, J.B., Alavi, A., Davis, A., Hackney, D., Judy, K., Mollman, J., Phillips, P.C., Wheeldon, E.B. and Wilson, J.M. (1996). Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial. Hum. Gene Ther., 7: 1465-1482.
5. Ezzeddine, Z.D., Martuza, R.L., Platika, D., Short, M.P., Malick, A., Choi, B. and Breakefield, X.O. (1992). Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol., 3: 608-614.
6. Gambhir, S.S., Barrio, J.R., Phelps, M.E., Iyer, M., Namavari, M., Satyamurthy, N., Wu, L., Green, L.A., Bauer, E., MacLaren, D.C., Nguyen, K., Berk, A.J., Cherry, S.R. and Herschman, H.R. (1999). Proc. Natl. Acad. Sci. USA, 96: 2333-2338.
7. Gambhir, S.S., Herschman, H.R., Cherry, S.R., Barrio, J.R., Satyamurthy, N., Toyokuni, T., Phelps, M.E., Larson, S.M., Balatoni, J., Finn, R., Sadelain, M., Tjuvajev, J. and Blasberg, R. (2000). Imaging transgene expression with radionuclide imaging technologies. Neoplasia, 2: 118-138.
8. Herholz, K., Wienhard, K. and Heiss, W.D. (1990). Validity of PET studies in brain tumors. Cerebrovasc. Brain Metab. Rev., 2: 240-265.
9. Jacobs, A., Voges, J., Reszka, R., Lercher, M., Gossmann, A., Kracht, L., Kaestle, C., Wagner, R., Wienhard, K. and Heiss, W.D. (2001). Positron - emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet, 358: 727-729.
10. Jacobs, A., Winkeler, A., Dittmar, C., Gossmann, A., Deckert, M., Kracht, L., Thiel, A., Garlip, G., Hilker, R., Sobesky, J., Vollmar, S., Kummer, C., Graf, R., Voges, J., Wienhard, K., Herholz, K. and Heiss, W.D. (2002). Molecular and functional imaging technology for the development of efficient treatment strategies for glioma. Technology in Cancer Research and Treatment, 1: 1-17.
11. Jager, P.L., Vaalburg, W., Pruim, J., de Vries, E.G., Langen, K.J. and Piers, D.A. (2001). Radiolabeled amino acids: basic aspects and clinical applications in oncology. J. Nucl. Med., 42: 432-445.
12. Klatzmann, D., Valery, C.A., Bensimon, G., Marro, B., Boyer, O., Mokhtari, K., Diquet, B., Salzmann, J.L. and Philippon, J. (1998). A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma. Hum. Gene Ther., 9: 2595-2604.
13. MacLaren, D.C., Gambhir, S.S., Satyamurthy, N., Barrio, J.R., Sharfstein, S., Toyokuni, T., Wu, L., Berk, A.J., Cherry, S.R., Phelps, M.E. and Herschman, H.R. (1999). Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals. Gene Ther., 6: 785-791.
14. Markert, J.M., Medlock, M.D., Rabkin, S.D., Gillespie, G.Y., Todo, T., Hunter, W.D., Palmer, C.A., Feigenbaum, F., Tornatore, C., Tufaro, F. and Martuza, R.L. (2000). Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial. Gene Ther., 7: 867-874.
15. Mesnil, M., Piccoli, C., Tiraby, G., Willecke, K. and Yamasaki, H. (1996). Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc. Natl. Acad. Sci. USA, 93: 1831-1835.
16. Mesnil, M. and Yamasaki, H. (2000). Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res., 60: 3989-3999.
17. Papanastassiou, V., Rampling, R., Fraser, M., Petty, R., Hadley, D., Nicoll, J., Harland., J., Mabbs, R. and Brown, M. (2002). The potential for efficacy of the modified (ICP 34.5(-)) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle study. Gene Ther., 9: 398-406.
18. Phelps, M.E. (2000). Inaugural article: positron emission tomography provides molecular imaging of biological processes. Proc. Natl. Acad. Sci. USA, 97: 9226-9233.
19. Price, P. (2001). PET as a potential tool for imaging molecular mechanisms of oncology in man. Trends Mol. Med., 7: 442-446.
20. Rainov, N.G. (2000). A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum. Gene Ther., 11: 2389-2401.
21. Ram, Z., Culver, K.W., Oshiro, E.M., Viola, J.J., DeVroom, H.L., Otto, E., Long, Z., Chiang, Y., McGarrity, G.J., Muul, L.M., Katz, D., Blaese, R.M. and Oldfield, E.H. (1997). Nat. Med., 3: 1354-1361.
22. Rampling, R., Cruickshank, G., Papanastassiou, V., Nicoll, J., Hadley, D., Brennan, D., Petty, R., MacLean, A., Harland, J., McKie, E., Mabbs, R. and Brown, M. (2000). Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma. Gene Ther., 7: 859-866.
23. Shand, N., Weber, F., Mariani, L., Bernstein, M., Gianella-Borradori, A., Long, Z., Sorensen, A.G. and Barbier, N. (1999). A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group. Hum . Gene Ther., 10: 2325-2335.
24. Tjuvajev, J.G., Stockhammer, G., Desai, R., Uehara, H., Watanabe, K., Gansbacher, B. and Blasberg, R.G. (1995). Imaging the expression of transfected genes in vivo. Cancer Res., 55: 6126-6132.
25. Tjuvajev, J.G., Avril, N., Oku, T., Sasajima, T., Miyagawa, T., Joshi, R., Safer, M., Beattie, B., DiResta, G., Daghighian, F., Augensen, F., Koutcher, J., Zweit, J., Humm, J., Larson, S.M., Finn, R. and Blasberg, R. (1998). Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res., 58: 4333-4341.
26. Trask, T.W., Trask, R.P., Aguilar-Cordova, E., Shine, H.D., Wyde, P.R., Goodman, J.C., Hamilton, W.J., Rojas-Martinez, A., Chen, S.H., Woo, S.L. and Grossman, R.G. (2000). Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors. Mol. Ther., 1: 195-203.
27. Voges, J., Weber, F., Reszka, R., Sturm, V., Jacobs, A., Heiss, W.D., Wiestler, O. and Kapp, J.F. (2002). Clinical protocol. Liposomal gene therapy with the herpes simplex thymidine kinase gene/ganciclovir system for the treatment of glioblastoma multiforme. Hum. Gene Ther., 13: 675-685.
28. Wiebe, L.I. and Knaus, E.E. (2001). Enzyme-targeted, nucleoside-based radiopharmaceuticals for scintigraphic monitoring of gene transfer and expression. Curr. Pharm. Des., 7: 1893-1906.
29. Zhu, J., Zhang, L., Hanisch, U.K., Felgner, P.L. and Reszka, R. (1996). A continuous intracerebral gene delivery system for in vivo liposome-mediated gene therapy. Gene Ther., 3: 472-476.