Liposomal gene therapy with the herpes simplex thymidine kinase gene/ganciclovir system for the treatment of glioblastoma multiforme

Human Gene Therapy

Volumn 13, Issue 5, 2002, Pages 675-685

  Voges, Jürgen ^a   Weber, Friedrich ^b   Reszka, Regina ^c   Sturm, Volker ^a   Jacobs, Andreas ^a   Heiss, Wolf Dieter ^a   Wiestler, Ottmar ^d   Friedrich Kapp, Joachim ^e  

^a UNIVERSITY OF COLOGNE   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c Max Delbr ck Center for Molecular Medicine   (Germany)

^d UNIVERSITY OF BONN   (Germany)

^e BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; LIPOSOME; THYMIDINE KINASE; TRACER; VIRUS PROTEIN;

CLINICAL TRIAL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTINUOUS INFUSION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG SYNTHESIS; FOLLOW UP; GENE THERAPY; GLIOBLASTOMA; GLIOMA; HERPES SIMPLEX VIRUS; HUMAN; MICROINJECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT MONITORING; QUALITY OF LIFE; REVIEW; RISK ASSESSMENT; STEREOTAXIC SURGERY; SURGICAL RISK; VIRAL GENE DELIVERY SYSTEM; VIRUS GENE; ARTICLE; CLINICAL PROTOCOL; ENZYMOLOGY; FEMALE; GENETICS; MALE; METHODOLOGY;

SIMPLEXVIRUS;

CLINICAL PROTOCOLS; FEMALE; GANCICLOVIR; GENE THERAPY; GLIOBLASTOMA; HUMANS; LIPOSOMES; MALE; SIMPLEXVIRUS; THYMIDINE KINASE; VIRAL PROTEINS;

EID: 0036211035     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340252837260     Document Type: Review

References (61)

1. Patterns of recurrence of malignant astrocytoma following stereotactic interstitial brachytherapy with iodine-125 implants
2. Convection-enhanced delivery of macromolecules in the brain
3. Long term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene
4. Computerized tomographic and pathologic studies of the untreated, quiescent and recurrent glioblastoma multiforme
5. Absence of contrast enhancement on CT brain scans of patients with supratentorial malignant glioma
6. Gene therapy for brain tumors: Regression of experimental gliomas with adenovirus-mediated gene transfer in vivo
7. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
8. Non-AIDS primary CNS lymphoma: First example of a durable response in a primary brain tumor using enhanced chemotherapy delivery without cognitive loss and without radiotherapy
9. Mechanism of action and selectivity of acyclovir
10. Optimization and evaluation of landmark-based image correlation
11. Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene
12. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations
13. Improved cationic lipid formulations for in vivo gene therapy
14. Tumor regression when a fraction of the tumor mass contains the HSV-TK gene
15. Cationic liposome-mediated gene transfer
16. Supratentorial malignant glioma: Patterns of recurrence and implications for external beam local treatment
17. Permeability of different experiment al brain tumor models to horseradish peroxidase
18. Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: A gene-marking and neuropathological study
19. Functional co-expression of HSV-1 thymidine kinase and green fluorescent protein: Implications for non-invasive imaging of transgene expression
20. 124I]FIAU in cat and man
21. Non-invasive assessment of vector-mediated gene expression in a phase I/II clinical glioma gene therapy trial by positron emission tomography
22. Vascular and interstitial barriers to delivery of therapeutic agents in tumors
23. The use of nitrogen mustards in the palliative treatment of carcinoma with particular reference to bron-chogenic carcinoma
24. A phase I/II study of herpes simplex virus type I thymidine kinase "suicide" gene therapy for recurrent glioblastoma
25. Gene therapists test puzzling "bystander effect" news
26. Intracerebral chemotherapy: Chronic microinfusion of cisplatin
27. Dopamine distribution and behavioral alterations resulting from dopamine infusion into the brain of lesioned rat
28. New methods of drug delivery
29. Polymers for the sustained release of proteins and other macromolecules
30. Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors
31. Permeability characteristics of brain adjacent to tumor rats
32. Convection enhanced distribution of large molecules in gray matter during interstitial drug infusion
33. Molecular evaluation of biopsy and autopsy specimens from patients receiving in vivo retro-viral gene therapy
34. Drug distribution in solid tissue of the brain following chronic local perfusion utilizing implanted osmotic minipumps
35. The trouble with vectors
36. Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase
37. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
38. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors
39. Transport of cisplatin in rat brain following microinfusion: An analysis
40. High-flow microinfusion: Tissue penetration and pharmacodynamics
41. Immunotherapy for cancer by direct gene transfer into tumors
42. Continuous intratumoral infusion of methotrexate for recurrent glioblastoma: A pilot study
43. Gene therapy for the treatment of brain tumors using intratumoral transduction with the thymidine kinase gene and intravenous ganciclovir
44. Chronic intratumoral chemotherapy of a rat tumor with cisplatin and fluorouracil
45. A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
46. In situ retroviral mediated gene transfer for the treatment of brain tumors in rats
47. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
48. Li-posome mediated transfer of marker and cytokine genes into rat and human glioblastoma cells in vitro and in vivo
49. Drugs released from polymers: Diffusion and elimination in brain tissue
50. The forms of growth in gliomas and their practical significance
51. Spatial distribution of dopamine, methotrexate and antipyrine during continuous intracerebral microperfusion
52. A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir
53. Measuring the quality of life of cancer patients: A concise QL-index for use by physicians
54. Current treatment modalities for brain tumors
55. Imaging the expression of transfected genes in vivo
56. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: A potential method for monitoring clinical gene therapy
57. Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography
58. Neuropathological aspects of liposomal in vivo suicide gene transfer to the F98 rat glioblastoma using liposomal and viral vectors
59. Simultaneous measurements of blood flow and blood-to-tissue transports in xenotransplanted medulloblastomas
60. Simultaneous measurements of blood flow and blood-to-tissue transports in xenotransplanted medulloblastomas
61. A continuous intracerebral gene delivery system for in vivo liposome-mediated gene therapy