메뉴 건너뛰기




Volumn 24, Issue 1, 2003, Pages 36-43

Association mapping of complex diseases in linked regions: Estimation of genetic effects and feasibility of testing rare variants

Author keywords

Epistasis; Gene environment interaction; Genotype relative risk; Replication; Sample size; Sibling relative risk

Indexed keywords

ARTICLE; DISEASE PREDISPOSITION; FEASIBILITY STUDY; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC MODEL; GENETIC VARIABILITY; RECURRENCE RISK;

EID: 0037224762     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/gepi.10216     Document Type: Article
Times cited : (17)

References (37)
  • 1
    • 0034758045 scopus 로고    scopus 로고
    • Genomewide scans of complex human diseases: True linkage is hard to find
    • Altmuller J, Palmer LJ, Fischer G, Scherb H, Wjst M. 2001. Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet 69:936-50.
    • (2001) Am J Hum Genet , vol.69 , pp. 936-950
    • Altmuller, J.1    Palmer, L.J.2    Fischer, G.3    Scherb, H.4    Wjst, M.5
  • 2
    • 0002348364 scopus 로고
    • The power and deceit of QTL experiments: Lessons from comparative QTL studies
    • Wilkinson DB (ed.). Washington, DC: American Seed Trade Association
    • Beavis WD. 1994. The power and deceit of QTL experiments: lessons from comparative QTL studies. In: Wilkinson DB (ed.) 49th Annual Corn and Sorghum Industry Research Conference. Washington, DC: American Seed Trade Association. p 250-66.
    • (1994) 49th Annual Corn and Sorghum Industry Research Conference , pp. 250-266
    • Beavis, W.D.1
  • 3
    • 0036137030 scopus 로고    scopus 로고
    • A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: Application to HLA in type 1 diabetes
    • Cordell HJ, Clayton DG. 2002. A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet 70:124-41.
    • (2002) Am J Hum Genet , vol.70 , pp. 124-141
    • Cordell, H.J.1    Clayton, D.G.2
  • 6
    • 0036155238 scopus 로고    scopus 로고
    • A perspective on epistasis: Limits of models displaying no main effect
    • Culverhouse R, Suarez BK, Lin J, Reich T. 2002. A perspective on epistasis: limits of models displaying no main effect. Am J Hum Genet 70:461-71.
    • (2002) Am J Hum Genet , vol.70 , pp. 461-471
    • Culverhouse, R.1    Suarez, B.K.2    Lin, J.3    Reich, T.4
  • 9
    • 0035212224 scopus 로고    scopus 로고
    • A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: Identification of new loci with evidence of interactions
    • European Consortium for IDDM Genome Studies. 2001. A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions. Am J Hum Genet 69:1301-13.
    • (2001) Am J Hum Genet , vol.69 , pp. 1301-1313
  • 11
    • 0034917944 scopus 로고    scopus 로고
    • A transmission/disequilibrium test that allows for genotyping errors in the analysis of single-nucleotide polymorphism data
    • Gordon D, Heath SC, Liu X, Ott J. 2001. A transmission/disequilibrium test that allows for genotyping errors in the analysis of single-nucleotide polymorphism data. Am J Hum Genet 69:371-80.
    • (2001) Am J Hum Genet , vol.69 , pp. 371-380
    • Gordon, D.1    Heath, S.C.2    Liu, X.3    Ott, J.4
  • 12
    • 0035209177 scopus 로고    scopus 로고
    • Large upward bias in estimation of locus-specific effects from genomewide scans
    • Goring HH, Terwilliger JD, Blangero J. 2001. Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet 69:1357-69.
    • (2001) Am J Hum Genet , vol.69 , pp. 1357-1369
    • Goring, H.H.1    Terwilliger, J.D.2    Blangero, J.3
  • 13
    • 0036183653 scopus 로고    scopus 로고
    • Sibling recurrence risk ratio as a measure of genetic effect: Caveat emptor!
    • Guo SW. 2002. Sibling recurrence risk ratio as a measure of genetic effect: caveat emptor! Am J Hum Genet 70:818-9.
    • (2002) Am J Hum Genet , vol.70 , pp. 818-819
    • Guo, S.W.1
  • 18
    • 0015091972 scopus 로고
    • Frequency in relatives for an all-or-none trait
    • James JW. 1971. Frequency in relatives for an all-or-none trait. Ann Hum Genet 35:47-9.
    • (1971) Ann Hum Genet , vol.35 , pp. 47-49
    • James, J.W.1
  • 20
    • 0033358557 scopus 로고    scopus 로고
    • A note on power approximations for the transmission/disequilibrium test
    • Knapp M. 1999. A note on power approximations for the transmission/disequilibrium test. Am J Hum Genet 64:1177-85.
    • (1999) Am J Hum Genet , vol.64 , pp. 1177-1185
    • Knapp, M.1
  • 21
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander E, Kruglyak L. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-7.
    • (1995) Nat Genet , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 22
    • 0027200763 scopus 로고
    • Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR
    • Lucassen AM, Julier C, Beressi JP, Boitard C, Froguel P, Lathrop M, Bell JI. 1993. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nat Genet 4:305-10.
    • (1993) Nat Genet , vol.4 , pp. 305-310
    • Lucassen, A.M.1    Julier, C.2    Beressi, J.P.3    Boitard, C.4    Froguel, P.5    Lathrop, M.6    Bell, J.I.7
  • 23
    • 0033623360 scopus 로고    scopus 로고
    • General equations for Pt, Ps, and the power of the TDT and the affected-sib-pair test
    • McGinnis R. 2000. General equations for Pt, Ps, and the power of the TDT and the affected-sib-pair test. Am J Hum Genet 67:1.340-7.
    • (2000) Am J Hum Genet , vol.67 , pp. 1340-1347
    • McGinnis, R.1
  • 24
    • 0032530165 scopus 로고    scopus 로고
    • Tests and estimates of allelic association in complex inheritance
    • Morton NE, Collins A. 1998. Tests and estimates of allelic association in complex inheritance. Proc Natl Acad Sci USA 95:11389-93.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11389-11393
    • Morton, N.E.1    Collins, A.2
  • 27
    • 0034969437 scopus 로고    scopus 로고
    • Are rare variants responsible for susceptibility to complex diseases?
    • Pritchard JK. 2001. Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet 69:124-37.
    • (2001) Am J Hum Genet , vol.69 , pp. 124-137
    • Pritchard, J.K.1
  • 28
    • 0035451780 scopus 로고    scopus 로고
    • On the allelic spectrum of human disease
    • Reich DE, Lander ES. 2001. On the allelic spectrum of human disease. Trends Genet 17:502-10.
    • (2001) Trends Genet , vol.17 , pp. 502-510
    • Reich, D.E.1    Lander, E.S.2
  • 29
    • 0025019555 scopus 로고
    • Linkage strategies for genetically complex traits. I. Multilocus models
    • Risch N. 1990. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 46:222-8.
    • (1990) Am J Hum Genet , vol.46 , pp. 222-228
    • Risch, N.1
  • 30
    • 0034660559 scopus 로고    scopus 로고
    • Searching for genetic determinants in the new millennium
    • Risch NJ. 2000. Searching for genetic determinants in the new millennium. Nature 405:847-56.
    • (2000) Nature , vol.405 , pp. 847-856
    • Risch, N.J.1
  • 31
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K. 1996. The future of genetic studies of complex human diseases. Science 273:1516-7.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 32
    • 0033925805 scopus 로고    scopus 로고
    • The relationship between the sibling recurrence-risk ratio and genotype relative risk
    • Rybicki BA, Elston RC. 2000. The relationship between the sibling recurrence-risk ratio and genotype relative risk. Am J Hum Genet 66:593-604.
    • (2000) Am J Hum Genet , vol.66 , pp. 593-604
    • Rybicki, B.A.1    Elston, R.C.2
  • 33
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin- dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-16.
    • (1993) Am J Hum Genet , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 34
    • 0032190353 scopus 로고    scopus 로고
    • Restrictions on components of variance for epistatic models
    • Tiwari HK, Elston RC. 1998. Restrictions on components of variance for epistatic models. Theor Popul Biol 54:161-74.
    • (1998) Theor Popul Biol , vol.54 , pp. 161-174
    • Tiwari, H.K.1    Elston, R.C.2
  • 35
    • 0035978779 scopus 로고    scopus 로고
    • Human genetics. Tackling common disease
    • Todd JA. 2001. Human genetics. Tackling common disease. Nature 411:537-9.
    • (2001) Nature , vol.411 , pp. 537-539
    • Todd, J.A.1
  • 37
    • 0035717139 scopus 로고    scopus 로고
    • Epistasis and its possible effects on transmission disequilibrium tests
    • Wilson SR. 2001. Epistasis and its possible effects on transmission disequilibrium tests. Ann Hum Genet 65:565-75.
    • (2001) Ann Hum Genet , vol.65 , pp. 565-575
    • Wilson, S.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.