The death associated protein (DAP) kinase homologue Dlk/ZIP kinase induces p19ARF- and p53-independent apoptosis

European Journal of Cancer

Volumn 39, Issue 2, 2003, Pages 249-256

  Kogel D ^a   Reimertz, C ^a   Dussmann H ^a   Mech, P ^a   Scheidtmann, K H ^b   Prehn, J H M ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Apoptosis; Dlk ZIP kinase; Mitochondrial depolarisation; p19ARF; p53

Indexed keywords

ARF PROTEIN; CASPASE 3; CYTOCHROME C; PROTEIN KINASE; PROTEIN KINASE DLK ZIP; PROTEIN P19; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; CYTOCHROME C GROUP; FLUORESCENT ANTIBODY TECHNIQUE; GENES, P53; MICE; MICE, INBRED BALB C; MITOCHONDRIA; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 0037220388     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(02)00477-X     Document Type: Article

References (28)

1. Inbal B., Shani G., Cohen O., Kissil J.L., Kimchi A. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. Mol Cell Biol. 20:2000;1044-1054.
2. Kögel D., Prehn J.H., Scheidtmann K.H. The DAP kinase family of pro-apoptotic proteins. novel players in the apoptotic game Bioessays. 23:2001;352-358.
3. Raveh T., Droguett G., Horwitz M.S., DePhino R.A., Kimchi A. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat Cell Biol. 3:2001;1-7.
4. Cohen O., Inbal B., Kissil J.L.et al. DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain. J Cell Biol. 146:1999;141-148.
5. Jang C.W., Chen C.H., Chen C.C., Chen Jy J., Su Y.H., Chen R.H. TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase. Nat Cell Biol. 10:2001;10.
6. Deiss L.P., Feinstein E., Berissi H., Cohen O., Kimchi A. identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 9:1995;15-30.
7. Pelled D., Raveh T., Riebeling C.et al. Death-associated protein- (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. J Biol Chem. 14:2001;14.
8. Kögel D., Plöttner O., Landsberg G., Christian S., Scheidtmann K.H. Cloning and characterization of Dlk, a novel serine/threonine kinase that is tightly associated with chromatin and phosphorylates core histones. Oncogene. 17:1998;2645-2654.
9. Kögel D., Bierbaum H., Preuss U., Scheidtmann K.H. C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity. Oncogene. 18:1999;7212-7218.
10. Page G., Kögel D., Rangnekar V., Scheidtmann K.H. Interaction partners of Dlk/ZIP kinase. co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis Oncogene. 18:1999;7265-7273.
11. Cohen O., Feinstein E., Kimchi A. DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity. EMBO J. 16:1997;998-1008.
12. Velentza A.V., Schumacher A.M., Weiss C., Egli M., Watterson D.M. A protein kinase associated with apoptosis and tumor suppression structure, activity, and discovery of peptide substrates. J Biol Chem. 276:2001;38956-38965.
13. Soengas M.S., Alarcon R.M., Yoshida H.et al. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science. 284:1999;156-159.
14. Robles A.I., Bemmels N.A., Foraker A.B., Harris C.C. APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis. Cancer Res. 61:2001;6660-6664.
15. Korsmeyer S.J., Gross A., Harada H.et al. Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules. Cold Spring Harb Symp Quant Biol. 64:1999;343-350.
16. Nakano K., Vousden K.H. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 7:2001;683-694.
17. Yu J., Zhang L., Hwang P.M., Kinzler K.W., Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 7:2001;673-682.
18. Oda E., Ohki R., Murasawa H.et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 288:2000;1053-1058.
19. Lomax M., Fried M. Polyoma virus disrupts ARF signaling to p53. Oncogene. 20:2001;4951-4960.
20. Quelle D.E., Zindy F., Ashmun R.A., Sherr C.J. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell. 83:1995;993-1000.
21. Harvey D.M., Levine A.J. p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev. 5:1991;2375-2385.
22. Ward M.W., Rego A.C., Frenguelli B.G., Nicholls D.G. Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. J Neurosci. 20:2000;7208-7219.
23. Bossy-Wetzel E., Newmeyer D.D., Green D.R. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 17:1998;37-49.
24. Kögel D., Reimertz C., Mech P.et al. Dlk/ZIP kinase-induced apoptosis in human medulloblastoma cells. requirement of the mitochondrial apoptosis pathway Brit. J. Cancer. 85:2001;1801-1808.
25. Eischen C.M., Roussel M.F., Korsmeyer S.J., Cleveland J.L. Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis. Mol Cell Biol. 21:2001;7653-7662.
26. Hemmati P.G., Gillissen B., Von Haefen C., Wendt J., Starck L., Guner D.et al. Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis. Oncogene. 21:2002;3149-3161.
27. Puthalakath H., Villunger A., O'Reilly L.A.et al. Bmf. a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis Science. 293:2001;1829-1832.
28. Inbal B., Cohen O., Polak-Charcon S., et al D.A.P. kinase links the control of apoptosis to metastasis. Nature. 390:1997;180-184.