Catecholamine-induced T-wave lability in congenital long QT syndrome: A novel phenomenon associated with syncope and cardiac arrest

Mayo Clinic Proceedings

Volumn 78, Issue 1, 2003, Pages 40-50

  Nemec, Jan ^a,b   Hejlik, Joseph B ^a   Shen, Win Kuang ^a   Ackerman, Michael J ^a  

^a MAYO CLINIC   (United States)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOLAMINE; DOBUTAMINE; PHENYLEPHRINE;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EXERCISE TEST; FEMALE; GENOTYPE; HEART ARREST; HIGH RISK POPULATION; HUMAN; LONG QT SYNDROME; MALE; QT INTERVAL; SYNCOPE; T WAVE;

EID: 0037217202     PISSN: 00256196     EISSN: None     Source Type: Journal    
DOI: 10.4065/78.1.40     Document Type: Article

References (40)

1. Ackerman MJ, Clapham DE. Ion channels - Basic science and clinical disease. N Engl J Med. 1997;336:1575-1586.
2. Ackerman MJ. The long QT syndrome: Ion channel diseases of the heart. Mayo Clin Proc. 1998;73:250-269.
3. Zipes DP. The long QT interval syndrome: A Rosetta stone for sympathetic related ventricular tachyarrhythmias. Circulation. 1991;84:1414-1419.
4. Roden DM, Spooner PM. Inherited long QT syndromes: A paradigm for understanding arrhythmogenesis. J Cardiovasc Electrophysiol. 1999;10:1664-1683.
5. Malik M, Batchvarov VN. Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol. 2000;36:1749-1766.
6. Wang Q, Curran ME, Splawski I, et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet. 1996;12:17-23.
7. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell. 1995;80:795-803.
8. Wang Q, Shen J, Splawski I, et al. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell. 1995;80:805-811.
9. Ks function. Nat Genet. 1997;17:338-340.
10. Kr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999;97:175-187.
11. Splawski I, Shen J, Timothy KW, et al. Spectrum of mutations in long-QT syndrome genes: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation. 2000;102:1178-1185.
12. Moss AJ, Schwartz PJ, Crampton RS, et al. The long QT syndrome: Prospective longitudinal study of 328 families. Circulation. 1991;84:1136-1144.
13. Garson A Jr, Dick M II, Fournier A, et al. The long QT syndrome in children: An international study of 287 patients. Circulation. 1993; 87:1866-1872.
14. Zareba W, Moss AJ, le Cessie S, et al. Risk of cardiac events in family members of patients with long QT syndrome, J Am Coll Cardiol. 1995;26:1685-1691.
15. Moss AJ, Zareba W, Hall WJ, et al. Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation. 2000;101:616-623.
16. Cruz Filho FE, Maia IG, Fagundes ML, et al. Electrical behavior of T-wave polarity alternans in patients with congenital long QT syndrome. J Am Coll Cardiol. 2000;36:167-173.
17. Fujimoto Y, Morita H, Fukushima KK, Ohe T. Nicorandil abolished repolarisation alternans in a patient with idiopathic long QT syndrome. Heart. 1999;82:e8.
18. Motoyasu M, Nishikawa H, Shimizu Y, et al. A case of congenital long QT syndrome associated with T wave alternans [in Japanese]. Kokyu To Junkan. 1992;40:195-198.
19. Schwartz PJ, Malliani A. Electrical alternation of the T-wave: Clinical and experimental evidence of its relationship with the sympathetic nervous system and with the long Q-T syndrome. Am Heart J. 1975;89:45-50.
20. Shimizu W, Kamakura S, Arakaki Y, Kamiya T, Shimomura K. T wave alternans in idiopathic long-QT syndrome: Insight from body surface mapping. Pacing Clin Electrophysiol. 1996;19:1130-1133.
21. Zareba W, Moss AJ, le Cessie S, Hall WJ. T wave alternans in idiopathic long QT syndrome. J Am Coll Cardiol. 1994;23:1541-1546.
22. Kaufman ES, Priori SG, Napolitano C, et al. Electrocardiographic prediction of abnormal genotype in congenital long QT syndrome: Experience in 101 related family members. J Cardiovasc Electrophysiol. 2001;12:455-461.
23. Nemec J, Ackerman MJ, Tester DJ, Hejlik J, Shen WK. Catecholamine-provoked microvoltage T wave altemans in genotyped long QT syndrome. Pacing Clin Electrophysiol. In press.
24. Atiga WL, Calkins H, Lawrence JH, Tomaselli GF, Smith JM, Berger RD. Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death. J Cardiovasc Electrophysiol. 1998;9: 899-908.
25. Atiga WL, Fananapazir L, McAreavey D, Calkins H, Berger RD. Temporal repolarization lability in hypertrophic cardiomyopathy caused by beta-myosin heavy-chain gene mutations. Circulation. 2000;101:1237-1242.
26. Berger RD, Kasper EK, Baughman KL, Marban E, Calkins H, Tomaselli GF. Beat-to-beat QT interval variability: Novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation. 1997;96:1557-1565.
27. Couderc JP, Zareba W, Burattini L, Moss AJ. Beat-to-beat repolarization variability in LQTS patients with the SCN5A sodium channel gene mutation. Pacing Clin Electrophysiol. 1999;22:1581-1592.
28. Nolasco JB, Dahlen RW. A graphic method for the study of alternation in cardiac action potentials. J Appl Physiol. 1968;25:191-196.
29. Chialvo DR, Jalife J. Non-linear dynamics of cardiac excitation and impulse propagation. Nature. 1987;330:749-752.
30. Chialvo DR; Gilmour RF Jr, Jalife J. Low dimensional chaos in cardiac tissue. Nature. 1990;343:653-657.
31. Karagueuzian HS, Khan SS, Hong K, et al. Action potential alternans and irregular dynamics in quinidine-intoxicated ventricular muscle cells: Implications for ventricular proarrhythmia. Circulation. 1993;87:1661-1672.
32. Hondeghem LM, Carlsson L, Duker G. Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation. 2001;103:2004-2013.
33. el-Sherif N, Caref EB, Yin H, Restivo M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: Tridimensional mapping of activation and recovery patterns. Circ Res. 1996;79:474-492.
34. Shimizu W, Antzelevitch C. Cellular and ionic basis for T-wave alternans under long-QT conditions. Circulation. 1999;99:1499-1507.
35. Yan GX, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation. 1998;98:1928-1936.
36. Antzelevitch C, Shimizu W, Yan GX, et al. The M cell: Its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol. 1999;10:1124-1152.
37. Moss AJ. Management of patients with the hereditary long QT syndrome. J Cardiovasc Electrophysiol. 1998;9:668-674.
38. Dorostkar PC, Eldar M, Belhassen B, Scheinman MM. Long-term follow-up of patients with long-QT syndrome treated with beta-blockers and continuous pacing. Circulation. 1999;100:2431-2436.
39. Malfatto G, Beria G, Sala S, Bonazzi O, Schwartz PJ. Quantitative analysis of T wave abnormalities and their prognostic implications in the idiopathic long QT syndrome. J Am Coll Cardiol. 1994;23: 296-301.
40. Zareba W, Badilini F, Moss AJ. Automatic detection of spatial and dynamic heterogeneity of repolarization. J Electrocardiol. 1994; 27(suppl):66-72.