Temporal repolarization lability in hypertrophic cardiomyopathy caused by β-myosin heavy-chain gene mutations

Circulation

Volumn 101, Issue 11, 2000, Pages 1237-1242

  Atiga, Walter L ^a   Fananapazir, Lameh ^b   McAreavey, Dorothea ^b   Calkins, Hugh ^a   Berger, Ronald D ^a,c  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Cardiomyopathy, hypertrophic; Electrocardiography; Genetics

Indexed keywords

MYOSIN HEAVY CHAIN;

AMBULATORY MONITORING; ARTICLE; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; HEART RATE; HEART VENTRICLE ARRHYTHMIA; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; MALE; PRIORITY JOURNAL; QT INTERVAL; REPOLARIZATION; SUDDEN DEATH;

EID: 0034696551     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.11.1237     Document Type: Article

References (35)

1. Fananapazir L, McAreavey D, Epstein ND. Hypertrophic cardiomyopathy. In: Zipes D, Jaliffe P, eds. Cardiac Electrophysiology, From Cell to Bedside. Philadelphia: Saunders; 1995:769-779.
2. McKenna WJ, Deanfield J, Faruqui A, England D, Oakley CM, Goodwin JK. Prognosis in hypertrophic cardiomyopathy: role of age and clinical, electrocardiographic and hemodynamic features. Am J Cardiol. 1981;47: 532-538.
3. McKenna WJ, England D, Doi YL, Deanfield JE, Oakley C, Goodwin JF. Arrhythmias in hypertrophic cardiomyopathy, I: influence on prognosis. Br Heart J. 1981;46:168-172.
4. Maron BJ, Savage DD, Wolfson JK, Epslein SE. Prognostic significance of 24 hour ambulatory monitoring in patients with hypertrophic cardiomyopathy: a prospective study. Am J Cardiol. 1981;48:252-257.
5. Fananapazir L, Chang AC, Epstein SE, McAreavey D. Prognostic determinants in hypertrophic cardiomyopathy: prospective evaluation of a therapeutic strategy based on clinical. Holter, hemodynamic, and electrophysiologic findings. Circulation. 1992;86:730-740.
6. Kulakowski P, Counihan PJ, Camm AJ, McKenna WJ. The value of time and frequency domain, and spectral temporal mapping analysis of the signal-averaged electrocardiogram in identification of patients with hypertrophic cardiomyopathy at increased risk of sudden death. Eur Heart J. 1993;14:941-950.
7. Epstein ND, Lin HJ, Fananapazir L. Genetic evidence of dissociation (generational skips) of electrical from morphologic forms of hypertrophic cardiomyopathy. Am J Cardiol. 1990;66:627-631.
8. Gilligan DM, Chan WL, Sbarouni E, Nihoyannopoulos P, Oakley CM. Autonomic function in hypertrophic cardiomyopathy. Br Heart J. 1993; 69:525-529.
9. Dritsas A, Sbarouni E, Gilligan D, Nihoyannopoulos P, Oakley C. QT-interval abnormalities in hypertrophic cardiomyopathy. Clin Cardiol. 1992;15:739-742.
10. Martin AM, Garson A Jr, Perry JC. Prolonged QT interval in hypertrophic and dilated cardiomyopathy in children. Am Heart J. 1994;127:64-70.
11. Buja G, Miorelli M, Turrini P, Melacini P, Nava A. Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death. Am J Cardiol. 1993; 72:973-976.
12. Fananapazir L, McAreavey D. Hypertrophic cardiomyopathy: evaluation and treatment of patients at high risk for sudden death. Pacing Clin Electrophysiol. 1997;20(part II):478-501.
13. Watkins H, Rosenzweig A, Hwang D, Levi T, McKenna W, Seidman CE, Seidman JG. Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy. N Engl J Med. 1992;326:1108-1114.
14. Anan R, Greve G, Thierfelder L, Watkins HC, McKenna WJ. Solomon S, Vecchio C, Shono H, Nakao S, Tanaka H, Mares A Jr, Towbin JA, Spirito P, Roberts R, Seidman JG, Seidman CE. Prognostic implications of novel β-cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy. J Clin Invest. 1994;93:280-285.
15. Epstein ND, Cohn GM, Cyran F, Fananapazir L. Differences in clinical expression of hypertrophic cardiomyopathy associated with two distinct mutations in the β-myosin heavy chain gene: a 908 Leu-Val mutation and a 403 Arg-Gln mutation. Circulation. 1992;86:345-352.
16. Fananapazir L, Epstein ND. Uenotype-phenotype correlations in hypertrophic cardiomyopathy: insights provided by comparison of kindreds with distinct and identical β-myosin heavy chain gene mutations. Circulation. 1994;89:22-32.
17. Tomaselli GF, Beuckelmann DJ, Calkins HG, Berger RD, Kessler PD, Lawrence JH, Kass D, Feldman AM, Marban E. Sudden cardiac death in heart failure: the role of abnormal repolarization. Circulation. 1994;90: 2534-2539.
18. Berger RD, Kasper EK, Baughman KL, Marban E, Calkins H, Tomaselli GF. Beat-to-beat QT interval variability. Novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation. 1997;96:1557-1565.
19. Berger RD, Akselrod S, Gordon D, Cohen RJ. An efficient algorithm for spectral analysis of heart rate variability. IEEE Trans Biomed Eng. 1986; 33:900-904.
20. Kay SM, Marple SL. Spectrum analysis: a modern perspective. Proc IEEE. 1981;69:1380-1419.
21. Berger RD, Saul JP, Cohen RJ. Transfer function analysis of autonomic regulation, I: the canine atrial rate response. Am J Physiol. 1989;25: H142-H152.
22. Solomon SC, Jarcho JA, McKenna W. Geisterfer-Lowrance A, Germain R, Salerni R, Seidman JG, Seidman CE. Familial hypertrophic cardiomyopathy is a genetically heterogeneous disease. J Clin Invest. 1990;86: 993-999.
23. Jarcho JA, McKenna W, Pare JAP, Solomon SD, Levi T, Donis-Keller H, Seidman JG, Seidman CE. Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1. N Engl J Med. 1990;320: 1372-1378.
24. Marian AJ, Yu QT, Mares A Jr, Roberts R, Perryman MB. Detection of a new mutation in the β-myosin heavy chain gene. J Clin Invest. 1992; 90:2156-65.
25. Thierfelder L, Watkins H, MacRae C, Lama R, McKenna W, Vosberg HP, Seidman JG, Seidman CE. Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. Cell. 1994;77:701-712.
26. Watkins H, McKenna WJ, Thierfelder L, Suk HJ, Anan R, O'Donoghue A, Spirito P, Matsumori A, Moravec CS, Seidman JG, Seidman CE. Mutations in the genes for cardiac troponin T and a-tropomyosin in hypertrophic cardiomyopathy. N Engl J Med. 1995;332:1058-1064.
27. Marian AJ, Roberts R. Recent advances in the molecular genetics of hypertrophic cardiomyopathy. Circulation. 1995;92:1336-1347.
28. Watkins H, Conner D, Thierfelder L, Jarcho JA, MacRae C, McKenna WJ, Maron BJ, Seidman JG, Seidman CE. Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy. Nat Genet. 1995;11:434-437.
29. Poetter K, Jiang H, Hassanzadeh S, Master SR, Chang A, Dalakas MC, Rayment I, Sellers JR, Fananapazir L, Epstein ND. Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle. Nat Genet. 1996;13: 63-69.
30. Kimura A, Harada H, Park JE, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagio T, Hwang TH, Choo JA, Chung KS, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Nat Genet. 1997;16:379-82.
31. Marian AJ, Roberts R. Molecular genetic basis of hypertrophic cardiomyopathy: genetic markers for sudden cardiac death. J Cardiovasc Electrophysiol. 1998;9:88-99.
32. Wigle ED, Rakowski H, Kimball BP, Williams WG. Hypertrophic cardiomyopathy: clinical spectrum and treatment. Circulation. 1995;92: 1680-1692.
33. Atiga WL, Calkins H, Lawrence JH, Tomaselli GF, Smith JM, Berger RD. Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death. J Cardiovasc Electrophysiol. 1998;9:899-908.
34. Momiyama Y, Hartikainen J, Nagayoshi H, Albrecht P, Kautzner J, Saumarez RC, McKenna WJ, Camm AJ. Exercise-induced T-wave alternans as a marker of high risk in patients with hypertrophic cardiomyopathy. Jpn Circ J. 1997;61:650-656.
35. Jumrussirikul P, Calkins H, Berger RD. Reproducibility of beat-to-beat QT interval variability. Circulation. 1997;96:1-760. Abstract.