Cyclosporin A and enterohepatic circulation of bile salts in rats: Decreased cholate synthesis but increased intestinal reabsorption

Journal of Pharmacology and Experimental Therapeutics

Volumn 304, Issue 1, 2003, Pages 356-363

  Hulzebos, Christian V ^a   Wolters, Henk ^a   Plösch, Torsten ^a   Kramer, Werner ^b   Stengelin, Siegfried ^b   Stellaard, Frans ^a   Sauer, Pieter J J ^a   Verkade, Henkjan J ^a   Kuipers, Folkert ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; CHOLIC ACID; CYCLOSPORIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; ENTEROHEPATIC CIRCULATION; HEPATOBILIARY SYSTEM; ILEUM; INTESTINE ABSORPTION; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

ANIMALS; BILE ACIDS AND SALTS; CARRIER PROTEINS; CHOLIC ACID; CHROMATOGRAPHY, GAS; CYCLOSPORINE; ENTEROHEPATIC CIRCULATION; FECES; ILEUM; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL ABSORPTION; INTESTINES; KINETICS; LIVER FUNCTION TESTS; MALE; MASS SPECTROMETRY; MEMBRANES; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; RADIOISOTOPE DILUTION TECHNIQUE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYMPORTERS;

EID: 0037215538     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.041640     Document Type: Article

References (40)

1. Arias IM (1993) Cyclosporin, the biology of the bile canaliculus and cholestasis. Gastroenterology 104:1558-1560.
2. Arrese M, Trauner M, Sacchiero RJ, Crossman MW, and Shneider BL (1998) Neither intestinal sequestration of bile acids nor common bile duct ligation modulate the expression and function of the rat ileal bile acid transporter. Hepatology 28:1081-1087.
3. Azer SA and Stacey NH (1993) Differential effects of cyclosporin A on the transport of bile acids by human hepatocytes. Biochem Pharmacol 46:813-819.
4. Ballatori N and Truong AT (1992) Glutathione as a primary osmotic driving force in hepatic bile formation. Am J Physiol 263:G617-G624.
5. Björkhem I (1985) Mechanisms of bile acid synthesis in mammalian liver, in Sterols and Bile Acids (Danielsson H and Sjövall J eds) pp 231-278, Elsevier Publishing Co., Amsterdam.
6. Böhme M, Müller M, Leier I, Jedlitschky G, and Keppler D (1994) Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology 107:255-265.
7. Burke JF, Pirsch JD, Ramos EL, Salomon DR, Stablein DM, Van Buren DH, and West JC (1994) Long-term efficacy and safety of cyclosporin in renal transplant recipients. New Engl J Med 331:358-363.
8. Campbell IM (1974) Incorporation and dilution values: Their calculation in mass spectrally assayed stable isotopes labeling experiments. Bioorg Chem 3:386-397.
9. Chan FK and Shaffer EA (1997) Cholestatic effects of cyclosporine in the rat. Transplantation 63:1574-1578.
10. Chanussot F, Botta Fridlund D, Lechene de la Porte P, Sbarra V, Portugal H, Pauli AM, Hauton J, Gauthier A, and Lafont H (1992) Effects of cyclosporine and corticosteroids on bile secretion in the rat. Transplantation 54:226-231.
11. Chen ZS, Kawabe T, Ono M, Aoki S, Sumizawa T, Furukawa T, Uchiumi T, Wada M, Kuwano M, and Akiyama SI (1999) Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Mol Pharmacol 56:1219-1228.
12. Dawson PA (1998) Intestinal bile acid transport; molecules, mechanisms and malabsorption, in Bile Acids and Cholestasis (Paumgartner G, Stiehl A, Gerok W, Keppler D and Leuschner U eds) pp 1-31, Kluwer Academic Publishers, London.
13. Galán AI, Muñoz ME, and Jiménez R (1999) S-Adenosylmethionine protects against cyclosporin A-induced alterations in rat liver plasma membrane fluidity and functions. J Pharmacol Exp Ther 290:774-781.
14. Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF, and Meier PJ (1998) The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 273:10046-10050.
15. Griffith OW (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106:207-212.
16. Hulzebos CV, Renfurm L, Bandsma RH, Verkade HJ, Boer T, Boverhof R, Tanaka H, Mierau I, Sauer PJJ, Kuipers F, et al. (2001) Measurement of cholic acid kinetics in plasma using a micro scale stable isotope technique: Application to rodents and man. J Lipid Res 42:1923-1929.
17. Jang I, Jung K, and Cho J (2000) Influence of age on duodenal brush border membrane and specific activities of brush border membrane enzymes in Wistar rats. Exp Anim 49:281-287.
18. Kadmon M, Klünemann C, Böhme M, Ishikawa T, Gorgas K, Otto G, Herfarth C, and Keppler D (1993) Inhibition by cyclosporin A of adenosine triphosphate-dependent transport from the hepatocyte into bile. Gastroenterology 104:1507-1514.
19. Kramer W, Wess G, Bewersdorf U, Corsiero D, Girbig F, Weyland C, and Stengelin S (1997) Topological photoaffinity labeling of the rabbit ileal Na+/bile-salt-cotransport system. Eur J Biochem 249:456-464.
20. Kuipers F, Havinga R, Bosschieter H, Toorop GP, Hindriks FR, and Vonk RJ (1985b) Enterohepatic circulation in the rat. Gastroenterology 88:403-411.
21. Kuipers F, Dijkstra T, Havinga R, van Asselt W, and Vonk RJ (1985a) Acute effects of pentobarbital-anaesthesia on bile secretion. Biochem Pharmacol 15:1731-1736.
22. Le Thai B, Dumont M, Michel A, Erlinger S, and Houssin D (1988) Cholestatic effect of cyclosporine in the rat. An inhibition of bile acid secretion. Transplantation 46:510-512.
23. Lillienau J, Crombie DL, Munoz J, Longmire-Cook SJ, Hagey LR, and Hofmann AF (1993) Negative feedback regulation of the ileal bile acid transport system in rodents. Gastroenterology 104:38-46.
24. Lowry OH, Roseborough NJ, Farr AL, and Randall RL (1951) Protein measurement with the folin reagents. J Biol Chem 193:265-275.
25. Meier PJ and Boyer JL (1990) Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes. Methods Enzymol 192:534-545.
26. Meier PJ and Stieger B (2002) Bile salt transporters. Annu Rev Physiol 64:635-661.
27. Moseley RH, Johnson TR, and Morrissette JM (1990) Inhibition of bile acid transport by cyclosporin A in rat liver plasma membrane vesicles. J Pharmacol Exp Ther 253:974-980.
28. Murphy GM, Billing BH, and Baron DN (1970) A fluorimetric and enzymatic method for the estimation of serum total bile acids. J Clin Pathol 23:594-598.
29. Pernthaler H, Klaus A, Weiss H, Klima G, and Margreiter R (1997) Prolonged administration of cyclosporine A causes an increase in spontaneous contractile activity of the rat intestine. Transpl Proc 29:695-696.
30. Plösch T, Kok T, Bloks VW, Smit MJ, Havinga R, Chimini G, Groen AK, and Kuipers F (2002) Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X-receptor (LXR) is independent of ABCA1. J Biol Chem 277:33870-33877.
31. Princen HMG, Meijer PJ, Wolthers BG, Vonk RJ, and Kuipers F (1991) Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis. Biochem J 275:501-505.
32. Roelofsen H, Vos TA, Schippers IJ, Kuipers F, Koning H, Moshage H, Jansen PL, and Muller M (1997) Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. Gastroenterology 112:511-521.
33. Sauer P, Klöters-Plachky P, and Stiehl A (1995) Inhibition of ileal bile acid transport by cyclosporin A in rat. Eur J Clin Invest 25:677-682.
34. Schmitz J, Preiser H, Maerstracei D, Ghosh BK, Cerda JJ, and Crane RK (1973) Purification of the human intestinal brush border membrane. Biochem Biophys Acta 323:98-112.
35. Stieger B, Hagenbuch B, Landmann L, Hochli M, Schroeder A, and Meier PJ (1994) In situ localization of the hepatocytic Na+/Taurocholate cotransporting polypeptide in rat liver. Gastroenterology 107:1781-1787.
36. Stravitz RT, Sanyal AJ, Pandak WM, Vlahcevic ZR, Beets JW, and Dawson PA (1997) Induction of sodium-dependent bile acid transporter messenger RNA, protein and activity in rat ileum by cholic acid. Gastroenterology 113:1599-1608.
37. Sun S, Greenstein SM, Kim DY, Schreiber TC, Schechner RS, and Tellis VA (1997) Nifedipine protects small intestine from cyclosporine-induced hemodynamic and functional impairment. J Surg Res 69:295-299.
38. Tredger JM, Roberts N, Sherwood R, Higgins G, and Keating J (2000) Comparison of five cyclosporin immunoassays with HPLC. Clin Chem Lab Med 38:1205-1207.
39. Wolters H, Spiering M, Gerding A, Sloof MJH, Kuipers F, Hardonk MH, and Vonk RJ (1991) Isolation and characterization of canalicular and basolateral plasma membrane fractions from human liver. Biochem Biophys Acta 1069:61-69.
40. Xu G, Shneider BL, Shefer S, Nguyen LB, Batta AK, Tint GS, Arrese M, Thevananther S, Ma L, Stengelin S, et al. (2000) Ileal bile acid transport regulates bile acid pool, synthesis and plasma cholesterol levels differently in cholesterol-fed rats and rabbits. J Lipid Res 41:298-304.