Granulomas in schistosome and mycobacterial infections: A model of local immune responses

Trends in Immunology

Volumn 24, Issue 1, 2003, Pages 44-52

  Sandor, Matyas ^a   Weinstock, Joel V ^b   Wynn, Thomas A ^c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CD1 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NEUROPEPTIDE; OSTEOPONTIN; T LYMPHOCYTE RECEPTOR; TUBERCULIN; TUMOR NECROSIS FACTOR ALPHA; VASOACTIVE INTESTINAL POLYPEPTIDE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL MODEL; ANTIGENICITY; BACTERIAL GROWTH; COMPARATIVE STUDY; CYTOTOXICITY; DELAYED HYPERSENSITIVITY; GAMMA DELTA T CELL; GRANULOMA; IMMUNE RESPONSE; MOUSE; MOUSE STRAIN; MYCOBACTERIOSIS; NATURAL KILLER CELL; NONHUMAN; REVIEW; SCHISTOSOMA; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

ANIMALS; CYTOKINES; GRANULOMA; HUMANS; MACROPHAGES; MYCOBACTERIUM INFECTIONS; NEUROPEPTIDES; SCHISTOSOMIASIS; T-LYMPHOCYTES;

EID: 0037213660     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(02)00006-6     Document Type: Review

References (78)

1. Epstein W.L. Granulomatous hypersensitivity. Prog. Aller. 11:1967;36-88.
2. Boros D.L. Granulomatous inflammations. Prog. Aller. 24:1978;183-267.
3. Kunkel S.L., et al. Animal models of granulomatous inflammation. Semin. Respir. Infect. 13:1998;221-228.
4. Saunders B.M., Cooper A.M. Restraining mycobacteria: role of granulomas in mycobacterial infections. Immunol. Cell Biol. 78:2000;334-341.
5. Triccas J.A., Gicquel B. Life on the inside: probing Mycobacterium tuberculosis gene expression during infection. Immunol. Cell Biol. 78:2000;311-317.
6. Chan K., et al. Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection. Proc. Natl Acad. Sci. USA. 99:2002;3920-3925.
7. Hogan L.H., et al. Mycobacterium bovis strain Bacillus Calmette-Guerin-induced liver granulomas contain a diverse TCR repertoire but a monoclonal T-cell population is sufficient for protective granuloma formation. J. Immunol. 166:2001;6367-6375.
8. Ladel C.H., et al. Contribution of α/β and γ/δ T lymphocytes to immunity against Mycobacterium bovis bacillus Calmette Guerin: studies with T-cell receptor-deficient mutant mice. Eur. J. Immunol. 25:1995;838-846.
9. + T cells as the source of IL-4. Eur. J. Immunol. 32:2002;1242-1252.
10. Ladel C.H., et al. Immune response to Mycobacterium bovis bacille Calmette Guerin infection in major histocompatibility complex class I- and II-deficient knock-out mice: contribution of CD4 and CD8 T cells to acquired resistance. Eur. J. Immunol. 25:1995;377-384.
11. Hernandez H.J., et al. Expression of class II, but not class I, major histocompatibility complex molecules is required for granuloma formation in infection with Schistosoma mansoni. Eur. J. Immunol. 27:1997;1170-1176.
12. Perlman D.C., et al. Tuberculosis in patients with human immunodeficiency virus infection. Semin. Respir. Infect. 14:1999;344-352.
13. Roach D.R., et al. TNF regulates chemokine induction essential for cell recruitment, granuloma formation and clearance of mycobacterial infection. J. Immunol. 168:2002;4620-4627.
14. Flynn J.L., et al. Tumor necrosis factor-α is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity. 2:1995;561-572.
15. Joseph A.L., Boros D.L. Tumor necrosis factor plays a role in Schistosoma mansoni egg-induced granulomatous inflammation. J. Immunol. 151:1993;5461-5471.
16. Qiu B., et al. Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation. Am. J. Pathol. 158:2001;1503-1515.
17. Hogan L.H., et al. CD4+ TCR repertoire heterogeneity in Schistosoma mansoni-induced granulomas. J. Immunol. 2002;. in press.
18. Hogan L.H., et al. TCR specificity in infection induced granulomas. Immunol. Lett. 68:1999;115-120.
19. Hogan L.H., et al. Mycobacterium bovis BCG-induced granuloma formation depends on γ interferon and CD40 ligand but does not require CD28. Infect. Immun. 69:2001;2596-2603.
20. Modlin R.L., et al. Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions. Nature. 339:1989;544-548.
21. Sandor M., et al. Two waves of γδ T cells expressing different Vδ genes are recruited into schistosome-induced liver granulomas. J. Immunol. 155:1995;275-284.
22. Gumperz J.E., Brenner M.B. CD1-specific T cells in microbial immunity. Curr. Opin. Immunol. 13:2001;471-478.
23. Chun T., et al. Induction of M3-restricted cytotoxic T-lymphocyte responses by N-formylated peptides derived from Mycobacterium tuberculosis. J. Exp. Med. 193:2001;1213-1220.
24. O'Regan A.W., et al. Osteopontin (Eta-1). in cell-mediated immunity: teaching an old dog new tricks. Immunol. Today. 21:2000;475-478.
25. Kunkel S.L., et al. Th1 and Th2 responses regulate experimental lung granuloma development. Sarcoidosis Vasc. Diffuse Lung Dis. 13:1996;120-128.
26. Cheever A.W., Yap G.S. Immunologic basis of disease and disease regulation in schistosomiasis. Chem. Immunol. 66:1997;159-176.
27. Stadecker M.J. The development of granulomas in schistosomiasis: genetic backgrounds, regulatory pathways and specific egg antigen responses that influence the magnitude of disease. Microbes Infect. 1:1999;505-510.
28. Fallon P.G. Immunopathology of schistosomiasis: a cautionary tale of mice and men. Immunol. Today. 21:2000;29-35.
29. Kaplan M.H., et al. Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. J. Immunol. 160:1998;1850-1856.
30. Jankovic D., et al. Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile. J. Immunol. 163:1999;337-342.
31. Chiaramonte M.G., et al. IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. J. Immunol. 162:1999;920-930.
32. Brunet L.R., et al. IL-4 protects against TNF-α-mediated cachexia and death during acute schistosomiasis. J. Immunol. 159:1997;777-785.
33. Hoffmann K.F., et al. IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J. Immunol. 164:2000;6406-6416.
34. La Flamme A.C., et al. IL-4 plays a crucial role in regulating oxidative damage in the liver during schistosomiasis. J. Immunol. 166:2001;1903-1911.
35. Chiaramonte M.G., et al. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J. Clin. Invest. 104:1999;777-785.
36. Appelberg R., et al. In vitro effects of interleukin-4 on interferon-γ-induced macrophage activation. Immunology. 76:1992;553-559.
37. Lang R., et al. Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. J. Immunol. 168:2002;3402-3411.
38. Turner J., et al. The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4. Exp. Gerontol. 36:2001;537-545.
39. Erb K.J., et al. IL-4, IL-5 and IL-10 are not required for the control of M. bovis-BCG infection in mice. Immunol. Cell Biol. 76:1998;41-46.
40. Jacobs M., et al. Increased resistance to mycobacterial infection in the absence of interleukin-10. Immunology. 100:2000;494-501.
41. Murray P.J., Young R.A. Increased antimycobacterial immunity in interleukin-10-deficient mice. Infect. Immun. 67:1999;3087-3095.
42. Flynn J.L., Chan J. Immunology of tuberculosis. Annu. Rev. Immunol. 19:2001;93-129.
43. MacMicking J.D., et al. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Natl Acad. Sci. USA. 94:1997;5243-5248.
44. Ehlers S., et al. NOS2-derived nitric oxide regulates the size, quantity and quality of granuloma formation in Mycobacterium avium-infected mice without affecting bacterial loads. Immunology. 98:1999;313-323.
45. Othieno C., et al. Interaction of Mycobacterium tuberculosis-induced transforming growth factor β1 and interleukin-10. Infect. Immun. 67:1999;5730-5735.
46. Toossi Z., Ellner J.J. The role of TGFβ in the pathogenesis of human tuberculosis. Clin. Immunol. Immunopathol. 87:1998;107-114.
47. Broeck J., et al. Tachykinin-like peptides and their receptors. A review. Ann. NY Acad. Sci. 897:1999;374-387.
48. Patel Y.C. Somatostatin and its receptor family. Front. Neuroendocrinol. 20:1999;157-198.
49. Blum A.M., et al. Substance P and somatostatin can modulate the amount of IgG2a secreted in response to schistosome egg antigens in murine Schistosomiasis mansoni. J. Immunol. 151:1993;6994-7004.
50. Rakasz E., et al. Localization and regulation of IFN-γ production within the granulomas of murine schistosomiasis in IL-4-deficient and control mice. J. Immunol. 160:1998;4994-4999.
51. Blum A.M., et al. Granuloma T lymphocytes in murine Schistosomiasis mansoni have somatostatin receptors and respond to somatostatin with decreased IFN-γ secretion. J. Immunol. 149:1992;3621-3626.
52. Blum A.M., et al. The substance P receptor is necessary for a normal granulomatous response in murine Schistosomiasis mansoni. J. Immunol. 162:1999;6080-6085.
53. Marriott I., Bost K.L. Substance P diminishes lipopolysaccharide and interferon-γ-induced TGF-β1 production by cultured murine macrophages. Cell. Immunol. 183:1998;113-120.
54. Kincy-Cain T., Bost K.L. Substance P-induced IL-12 production by murine macrophages. J. Immunol. 158:1997;2334-2339.
55. Weinstock J.V., et al. Macrophages within the granulomas of murine Schistosoma mansoni are a source of a somatostatin 1-14-like molecule. Cell. Immunol. 131:1990;381-390.
56. Elliott D.E., et al. Preprosomatostatin messenger RNA is expressed by inflammatory cells and induced by inflammatory mediators and cytokines. J. Immunol. 160:1998;3997-4003.
57. Weinstock J.V. Vasoactive intestinal peptide regulation of granulomatous inflammation in murine Schistosomiasis mansoni. Adv. Neuroimmunol. 6:1996;95-105.
58. Blum A.M., et al. Substance P regulates somatostatin expression in inflammation. J. Immunol. 161:1998;6316-6322.
59. Cook G.A., et al. Molecular evidence that granuloma T lymphocytes in murine Schistosomiasis mansoni express an authentic substance P (NK-1) receptor. J. Immunol. 152:1994;1830-1835.
60. Ho W.Z., et al. Human monocytes and macrophages express substance P and neurokinin-1 receptor. J. Immunol. 159:1997;5654-5660.
61. Goode T., et al. Neurokinin-1 receptor expression in inflammatory bowel disease: molecular quantitation and localisation. Gut. 47:2000;387-396.
62. Germonpre P.R., et al. Presence of substance P and neurokinin 1 receptors in human sputum macrophages and U-937 cells. Eur. Respir. J. 14:1999;776-782.
63. Blum A.M., et al. Interleukin 12 and antigen independently induce substance P receptor expression in T cells in murine Schistosomiasis mansoni. FASEB J. 15:2001;950-957.
64. Bost K.L., et al. Modulation of the mRNAs encoding substance P and its receptor in rat macrophages by LPS. Reg. Immunol. 4:1992;105-112.
65. Marriott I., Bost K.L. IL-4 and IFN-γ upregulate substance P receptor expression in murine peritoneal macrophages. J. Immunol. 165:2000;182-191.
66. Elliott D.E., et al. SSTR2A is the dominant somatostatin receptor subtype expressed by inflammatory cells, is widely expressed and directly regulates T cell IFN-γ release. Eur. Respir. J. 29:1999;2454-2463.
67. Elliott D.E., Weinstock J.V. Granulomas in murine Schistosomiasis mansoni have a somatostatin immunoregulatory circuit. Metabolism. 45:1996;88-90.
68. Hesse M., et al. NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease. Am. J. Pathol. 157:2000;945-955.
69. Hoffmann K.F., et al. IFN-γ, IL-12 and TNF-α are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12. J. Immunol. 161:1998;4201-4210.
70. Modolell M., et al. Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by Th1 and Th2 cytokines. Eur. J. Immunol. 25:1995;1101-1104.
71. Stein M., et al. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J. Exp. Med. 176:1992;287-292.
72. Goerdt S., Orfanos C.E. Other functions, other genes: alternative activation of antigen-presenting cells. Immunity. 10:1999;137-142.
73. + T cells correlates with Th1/Th2 phenotype. J. Immunol. 160:1998;5347-5354.
74. Hesse M., et al. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J. Immunol. 167:2001;6533-6544.
75. Dunn M.A., et al. Proline trapping in granulomas, the site of collagen biosynthesis in murine schistosomiasis. Hepatology. 1:1981;28-32.
76. Vanden Sandor M. Granuloma models in immunology. Methods. 3:1996;203. Editorial.
77. Modlin R.L. Th1-Th2 paradigm: insights from leprosy. J. Invest. Dermatol. 102:1994;828-832.
78. Salgame P., et al. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T-cell clones. Science. 254:1991;279-282.