The development of granulomas in schistosomiasis: Genetic backgrounds, regulatory pathways, and specific egg antigen responses that influence the magnitude of disease

Microbes and Infection

Volumn 1, Issue 7, 1999, Pages 505-510

  Stadecker, Miguel J ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; CYTOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PARASITE ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANTIGEN RECOGNITION; EGG; EXPERIMENTAL MODEL; GRANULOMA; HUMAN; IMMUNOPATHOLOGY; IMMUNOREGULATION; KNOCKOUT MOUSE; LIVER GRANULOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCHISTOSOMA; SCHISTOSOMIASIS;

ANIMALIA; SCHISTOSOMA;

EID: 0032717153     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(99)80089-6     Document Type: Article

References (43)

1. Akhiani A.A., Lycke N., Nilsson L.A., Olling S., Ouchterlony O. Lack of interferon-γ receptor does not influence the outcome of infection in murine schistosomiasis mansoni. Scand. J. Immunol. 43:1996;257-262.
2. Araujo M.I., deJesus A.R., Bacellar O., Sabin E., Pearce E., Carvalho E.M. Evidence of T helper type 2 activation in human schistosomiasis. Eur. J. Immunol. 26:1996;1399-1403.
3. Bogen S., Flores Villanueva P.O., McCusker M.E., Fogelman I., Garifallou M., El Attar S., Kwan P., Stadecker M.J. In situ analysis of cytokine responses in experimental murine schistosomiasis. Lab. Invest. 73:1995;252-258.
4. Boros D.L. Immunoregulation of granuloma formation in murine schistosomiasis mansoni. Ann. NY Acad. Sci. 465:1986;313-323.
5. Bosshardt S.C., Freeman G.L., Secor W.E., Colley D.G. IL-10 deficit correlates with chronic hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni. Parasite Immunol. 8:1997;347-353.
6. Cai Y., Langley J.G., Smith D.I., Boros D.L. A cloned major Schistosoma mansoni egg antigen with homologies to small heat shock proteins elicits Th1 responsiveness. Infect. Immun. 64:1996;1750-1755.
7. Cao M., Chao H., Doughty B.L. Cloning of a cDNA encoding an egg antigen homologue from Schistosoma mansoni, Mol. Biochem. Parasitol. 58:1993;169-177.
8. Cheever A.W., Duvall R.H., Hallack T.A. Variation of hepatic fibrosis and granuloma size among mouse strains infected with Schistosoma mansoni. Am. J. Trop. Med. Hyg. 37:1987;85-97.
9. Chen Y., Boros D.L. Identification of the immunodominant T cell epitope of p38 a major egg antigen and characterization of the epitope-specific Th responsiveness during murine schistosomiasis mansoni. J. Immunol. 160:1998;5420-5427.
10. Chensue S.W., Terebuh P.D., Warmington K.S., Hershey S.D., Evanoff H.L., Kunkel S.L., Higashi G.I. Role of IL-4 and IFNγ in Schistosoma mansoni egg-induced hypersensitivity granuloma formation. Orchestration relative contribution and relationship to macrophage function. J. Immunol. 148:1992;900-906.
11. + T helper type 1 lymphocytes. J. Immunol. 147:1991;3921-3925.
12. + Th1-type lymphocytes. J. Immunol. 150:1993;1413-1421.
13. Colley D.G., Montesano M.A., Eloi-Santos S.M., Powell M.R., Parra J.C., Goes A., Doughty B.L., Correa-Oliveira R., Rocha R.S., Gazzinelli G. Idiotype networks in schistosomiasis. McAdam K.P.W. New Strategies in Parasitology. 1989;179-190 Churchill Livingston Edinburgh.
14. Davis R.S., Kazura J.W., Mahoud A.A., Fanning M.M., Peters P.A. Immunopathology of murine infection with S. mansoni: Relationship of genetic background to hepatosplenic disease and modulation. J. Inf. Dis. 144:1981;148-153.
15. Flores Villanueva P.O., Chikunguwo S.M., Harris T.H., Stadecker M.J. Role of IL-10 on antigen-presenting cell function for schistosomal egg-specific monoclonal T helper cell responses in vitro and in vivo. J. Immunol. 151:1993;3192-3198.
16. Flores Villanueva P.O., Reiser H., Stadecker M.J. Regulation of T helper cell responses in experimental murine schistosomiasis by IL-10. Effect on expression of B7 and B 7-2 costimulatory molecules by macrophages. J. Immunol. 153:1994;5190-5199.
17. Flores Villanueva P.O., Zheng X.X., Strom T., Stadecker M.J. IL-10 and IL-10/Fc treatment down-regulate egg antigen-specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis. J. Immunol. 156:1996;3315-3320.
18. Hernandez H.J., Wang Y., Tzellas N., Stadecker M.J. Expression of class II but not class I major histocompatibility molecules is required for granuloma formation in infection with Schistosoma mansoni, Eur. J. Immunol. 27:1997;1170-1176.
19. Hernandez J., Wang Y., Stadecker M.J. In infection with Schistosoma mansoni B cells are required for Th2 responses but not for granuloma formation. J. Immunol. 158:1997;4832-4837.
20. Hernandez H.J., Trzyna W.C., Cordingley J.S., Brodeur P.H., Stadecker M.J. Differential antigen recognition by T cell hybridomas from strains of mice developing polar forms of granulomatous inflammation in response to eggs of Schistosoma mansoni, Eur. J. Immunol. 27:1997;666-670.
21. + T helper cell response to dominant epitope peptide of major egg antigen Sm-p40. Exp. Parasitol. 90:1998;122-130.
22. King C.L., Mahanty S., Kumaraswami V., Abrams J.S., Regunathan J., Jayaraman K., Ottesen E.A., Nutman T.B. Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset. J. Clin. Invest. 92:1993;1667-1673.
23. King C.L., Medhat A., Malhotra I., Nafeh M., Helmy A., Khaudary J., Ibrahim S., El-Sherbiny M., Zaky S., Stupi J., Brustoski K., Shehata M., Shata M.T. Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity. J. Immunol. 156:1996;4715-4721.
24. Lukacs N.W., Boros D.L. Utilization of fractionated soluble egg antigens reveals selectively modulated granulomatous and lymphokine responses during murine schistosomiasis mansoni. Infect. Immun. 60:1992;3209-3216.
25. Mahanty S., Nutman T.B. Immunoregulation in human lymphatic filariasis: the role of IL-10. Parasite Immunol. 17:1995;385-392.
26. Malaquias L.C.C., Falcao P.L., Correa Oliveira R., Wilson R.A. IL-10 is an important factor in controlling morbidity in schistosomiasis mansoni. International Symposium on Schistosomiasis Belo Horizonte Brazil. 1997;72.
27. Marquet S., Abel L., Hillaire D., Dessein H., Kalil J., Feingold J., Weissenbach J., Dessein A.J. Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33. Nat. Genet. 2:1996;181-184.
28. Mathew R.C., Boros D.L. Anti-L3T4 antibody treatment suppresses granuloma formation and abrogates antigen induced interleukin 2 production in Schistosoma mansoni infection. Infect. Immun. 54:1986;820-826.
29. Mwatha J.K., Kimani G., Kamau T., Mbugua G.G., Ouma J.H., Mumo J., Fulford A.J.C, Jones F.M., Butterworth A.E., Roberts M.B., Dunne D.W. High levels of TNF soluble TNF receptors soluble ICAM-1 and IFN-γ but low levels of IL-5 are associated with hepatosplenic disease in human schistosomiasis mansoni. J. Immunol. 160:1998;1992-1999.
30. Nene V., Dunne D.W., Johnson K.S., Taylor D.W., Cordingley J.S. Sequence and expression of a major egg antigen from Schistosoma mansoni. Homologies to heat shock proteins and alpha-crystallins. Mol. Biochem. Parasitol. 21:1986;179-188.
31. Pearce E.J., Caspar P., Grzych J.M., Lewis F., Sher A. Down regulation of Th1 cytokine production accompanies induction of Th2 responses by a parasite helminth Schistosoma mansoni. J. Exp. M. 173:1991;159-166.
32. Pearce E.J., Cheever A., Leonard S., Covalesky M., Fernandez-Botran R., Kohler G., Kopf M. Schistosoma mansoni in IL-4-deficient mice. Int. Immunol. 8:1996;435-444.
33. Rezende S.A., Oliveira V.R., Silva A.M., Alves J.B., Goes A.M., Reis L.F.L. Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection. Infect. Immun. 65:1997;3457-3461.
34. Secor W.E., del Corral H., dos Reis M.G., Ramos E.A., Zimon A.E., Matos E.P., Reis E.A., doCarmo T.M., Hirayama K., David R.A., David J.R., Harn D.A. Association of hepatosplenic schistosomiasis with HLA-DQB1, 0201. J. Infect. Dis. 174:1996;1131-1135.
35. Stadecker M.J., Flores Villanueva P.O. Accessory cell signals regulate T helper cell responses: from basic immunology to a model of helminthic disease. Immunol. Today. 15:1994;571-574.
36. Stadecker M.J., Hernandez H.J. The immune response and immunopathology in infection with Schistosoma mansoni: A key role of major egg antigen Sm-p40. Parasite Immunol. 20:1998;217-221.
37. Taylor-Robinson A.W., Phillips R.S. B cells are required for the switch from Th1-to Th2-regulated immune response to Plasmodium chabaudi chabaudi infection. Infect. Immun. 62:1994;2490-2498.
38. + T cell subsets to Plasmodium chabaudi in B cell deficient mice. Int. Immunol. 5:1993;1343-1348.
39. vonLichtenberg F.C. Host response to eggs of Schistosoma mansoni. I. Granuloma formation in the unsensitized laboratory mouse. Am. J. Trop. Med. Hyg. 41:1962;711-731.
40. Wynn T.A., Eltoum I., Cheever A.W., Sher A. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunol. 151:1993;1430-1440.
41. Wynn T.A., Eltoum I., Oswald I.P., Cheever A.W., Sher A. Endogenous IL-12 regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J. Exp. M. 179:1994;1551-1561.
42. Wynn T.A., Jankovic D., Hieny S., Zioncheck K., Jardieu P., Cheever A.W., Sher A. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma. J. Immunol. 154:1995;3999-4009.
43. Yamashita T., Boros D.L. IL-4 influences IL-2 production and granulomatous inflammation in murine schistosomiasis mansoni. J. Immunol. 149:1992;3659-3664.