Localization and regulation of IFN-γ production within the granulomas of murine schistosomiasis in IL-4-deficient and control mice

Journal of Immunology

Volumn 160, Issue 10, 1998, Pages 4994-4999

  Rakasz, Eva ^a   Blum, Arthur M ^a   Metwali, Ahmed ^a   Elliott, David E ^a   Li, Jie ^a   Ballas, Zuhair K ^a   Qadir, Khurram ^a   Lynch, Richard ^a   Weinstock, Joel V ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; RECOMBINANT INTERLEUKIN 12; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GRANULOMA; HELPER CELL; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; FEMALE; GRANULOMA; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-4; KILLER CELLS, NATURAL; MICE; MICE, INBRED C57BL; SCHISTOSOMIASIS; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032524989     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Metwali, A., D. Elliott, A. M. Blum, J. Li, M. Sandor, R. Lynch, N. Noben-Trauth, and J. V. Weinstock. 1996. The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice. J. Immunol. 157:4546.
2. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
3. Murphy, E., K. Shibuya, N. Hosken, P. Openshaw, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1996. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med. 183:901.
4. Noben-Trauth, N., N. G. Kohler, K. Burki, and B. Ledermann. 1996. Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line. Transgenic Res. 5:1.
5. Peters, P. A., and K. S. Warren. 1995. A rapid method of infecting mice and other laboratory animals with Schistosoma mansoni: subcutaneous injection. J. Parasitol. 131:558.
6. Elliott, D. E. 1996. Methods used to study immunoregulation of schistosome egg granulomas. ImmunoMethods 9:255.
7. + T cells upon NKR-P1 cross-linking. J. Exp. Med. 183:2391.
8. + T cell responses during infection with the helminth Schistosoma mansoni. J. Immunol. 157:3046.
9. + T cells in vivo. J. Immunol 151:1391.
10. Hernandez, H. J., Y. Wang, N. Tzellas, and N. J. Stadecker. 1997. Expression of class II, but not class I, major histocompatibility complex molecules is required for granuloma formation in infection with Schistosoma mansoni. Eur. J. Immunol 72:1170.
11. Yap, G., A. Cheever, P. Caspar, D. Jankovic, and A. Sher. 1997. Unimpaired down-modulation of the hepatic granulomatous response in CDS T-cell- and γ-interferon-deficient mice chronically infected with Schistosoma mansoni. Infect. Immun. 65:2583.
12. Mocci, S., and R. L. Coffman. 1997. The mechanism of in vitro T helper cell type 1 to T helper cell type 2 switching in highly polarized Leishmania major-specific T cell populations. J. Immunol. 158:1559.
13. Flores-Villanueva, P. O., H. Reiser, and M. J. Stadecker. 1994. Regulation of T helper cell responses in experimental murine schistosomiasis by IL-10: effect on expression of B7 and B7-2 costimulatory molecules by macrophages. J. Immunol. 153:5190.
14. + T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection. J. Immunol. 147:2713.
15. Chensue, S. W., J. H. Ruth, K. Warmington, P. Lincoln, and S. L. Kunkel. 1995. In vivo regulation of macrophage IL-12 production during type 1 and type 2 cytokine-mediated granuloma formation. J. Immunol. 155:3546.
16. Flores-Villanueva, P. O., X. X. Zheng, T. B. Strom, and M. J. Stadecker. 1996. Recombinant IL-10 and IL-10F/c treatment down-regulate egg antigen-specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis. J. Immunol. 156:3315.
17. Kresina, T. F., Q. He, S. D. Esposti, and M. A. Zern. 1994. Gene expression of transforming growth factor β1 and extracellular matrix proteins in murine Schistosoma mansoni infection. Gastroenterology 107:773.
18. Sporn, M. B., and A. B. Roberts. 1992. Transforming growth factor-β: recent progress and new challenges. J. Cell Biol. 119:1017.
19. Christ, M., N. L. McCartney-Francis, A. B. Kulkarni, J. M. Ward, D. E. Mizel, C. L. Mackall, R. E. Gress, K. L. Hines, H. Tian, S. Karlsson, and S. M. Wahl. 1994. Immune dysregulation in TGF-β1-deficient mice. J. Immunol. 153:1936.
20. Strober, W., B. Kelsall, I. Fuss, T. Marth, B. Ludviksson, R. Ehrhardt, and M. Neurath. 1997. Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation. Immunol. Today 18:61.
21. Barral-Netto, M., A. Barral, C. E. Brownell, Y. A. W. Skeiky, L. R. Ellingsworth, D. R. Twardzik, and S. G. Reed. 1992. Transforming growth factor-β in Leishmanial infection: a parasite escape mechanism. Science 257:545.
22. Toossi, Z., P. Gogate, H. Shiratsuchi, T. Young, and J. J. Ellner. 1995. Enhanced production of TGF-β by blood monocytes from patients with active tuberculosis and presence of TGF-β in tuberculous granulomatous lung lesions. J. Immunol. 154:465.
23. + T-cell subsets. Proc. Natl. Acad. Sci. USA 91:18.
24. +) outgrowth in murine schistosomiasis is genetically restricted and is largely due to activation by polyactosamine sugars. J. Immunol. 158:338.
25. Chensue, S. W., K. S. Warmington, J. H. Ruth, P. S. Sanghi, P. Lincoln, and S. L. Kunkel. 1996. Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production. J. Immunol. 157:4602.
26. Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1996. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:317.
27. Rogge, L., L. Barberis-Maino, M. Biffi, N. Passini, D. H. Presky, U. Gubler, and F. Sinigaglia. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825.