The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni

Journal of Immunology

Volumn 162, Issue 10, 1999, Pages 6080-6085

  Blum, Arthur M ^a   Metwali, Ahmed ^a   Kim Miller, Mindy ^b   Li, Jie ^a   Qadir, Khurram ^a   Elliott, David E ^a   Lu, Bao ^c   Fabry, Zsuzsa ^b   Gerard, Norma ^c   Weinstock, Joel V ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 4; INTERLEUKIN 5; SUBSTANCE P; SUBSTANCE P RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE DISRUPTION; GRANULOMATOUS INFLAMMATION; INFLAMMATORY CELL; LIVER GRANULOMA; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SPLEEN CELL; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; B-LYMPHOCYTES; CYTOKINES; GENES, REPORTER; GRANULOMA; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; INTERFERON TYPE II; LIVER; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; RECEPTORS, NEUROKININ-1; RNA, MESSENGER; SCHISTOSOMIASIS MANSONI; TH2 CELLS;

EID: 0033563013     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Weinstock, J. V., D. Elliott, A. Metwali, A. Blum, J. Lie, K. Qadir, and M. Sandor. 1998. Immunoregulation within the granulomas of murine schistosomiasis mansoni. Res. Immunol. In press.
2. Maggi, C. A. 1997. The effects of tachykinins on inflammatory and immune cells. Regul. Pept. 70:75.
3. Weinstock, J. V., A. Blum, J. Walder, and R. Walder. 1988. Eosinophils from granulomas in murine schistosomiasis mansoni produce substance P. J. Immunol. 141:961.
4. Weinstock, J. V., and D. Elliott. 1998. The substance P and somatostatin interferon-γ immunoregulatory circuit. Ann. NY Acad. Sci. 840:532.
5. Cook, G. A., D. Elliott, A. Metwali, A. M. Blum, M. Sandor, R. Lynch, and J. V. Weinstock. 1994. Molecular evidence that granuloma T lymphocytes in murine schistosomiasis mansoni express an authentic substance P (NK-1) receptor. J. Immunol. 152:1830.
6. Blum, A. M., A. Metwali, G. Cook, R. C. Mathew, D. Elliott, and J. V. Weinstock. 1993. Substance P modulates antigen-induced, IFN-γ production in murine schistosomiasis mansoni. J. Immunol. 151:225.
7. Blum, A. M., A. Metwali, R. C. Mathew, D. Elliott, and J. V. Weinstock. 1993. Substance P and somatostatin can modulate the amount of IgG2a secreted in response to schistosome egg antigens in murine schistosomiasis mansoni. J. Immunol. 151:6994.
8. Kincy-Cain, T., and K L. Bost. 1996. Increased susceptibility of mice to Salmonella infection following in vivo treatment with the substance P antagonist, spantide II. J. Immunol. 157:255.
9. Bozic, C. R., B. Lu, U. E. Hopken, C. Gerard, and N. P. Gerard. 1996. Neurogenic amplification of immune complex inflammation. Science 273:1722.
10. Elliott, D. E. 1996. Methods used to study immunoregulation of schistosome egg granulomas. Methods 9:255.
11. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
12. Metwali, A., D. Elliott, A. M. Blum, J. Li, M. Sandor, R. Lynch, T. Noben, and J. V. Weinstock. 1996. The granulomatous response in murine schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice. J. Immunol. 157:4546.
13. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15:749.
14. Yap, G., A. Cheever, P. Caspar, D. Jankovic, and A. Sher. 1997. Unimpaired down-modulation of the hepatic granulomatous response in CD8 T-cell- and γ interferon-deficient mice chronically infected with Schistosoma mansoni. Infect. Immun. 65:2583.
15. Schratzberger, P., N. Reinisch, W. M. Prodinger, C. M. Kahler, B. A. Sitte, R. Bellmann, R. Fischer-Colbrie, H. Winkler, and C. J. Wiedermann. 1997. Differential chemotactic activities of sensory neuropeptides for human peripheral blood mononuclear cells. J. Immunol. 158:3895.
16. Baluk, P., C. Bertrand, P. Geppetti, D. M. McDonald, and J. A. Nadel. 1995. NK1 receptors mediate leukocyte adhesion in neurogenic inflammation in the rat trachea. Am. J. Physiol. 268:L263.
17. Nguyen, L. S., A. C. Villablanca, and J. C. Rutledge. 1995. Substance P increases microvascular permeability via nitric oxide-mediated convective pathways. Am. J. Physiol. 268:R1060.
18. Levite, M., L. Cahalon, R. Hershkoviz, L. Steinman, and O. Lider. 1998. Neuropeptides, via specific receptors, regulate T cell adhesion to fibronectin. J. Immunol. 160:993.
19. Kahler, C. M., M. Herold, N. Reinisch, and C. J. Wiedermann. 1996. Interaction of substance P with epidermal growth factor and fibroblast growth factor in cyclooxygenase-dependent proliferation of human skin fibroblasts. J. Cell. Physiol. 166:601.
20. Ho, W. Z., J. P. Lai, X. H. Zhu, M. Uvaydova, and S. D. Douglas. 1997. Human monocytes and macrophages express substance P and neurokinin-1 receptor. J. Immunol. 159:5654.
21. Elliott, D. E., A. M. Blum, J. Li, A. Metwali, and J. V. Weinstock. 1998. Preprosomatostatin messenger RNA is expressed by inflammatory cells and induced by inflammatory mediators and cytokines. J. Immunol. 160:3997.
22. Blum, A. M., D. E. Elliott, A. Metwali, J. Li, K. Qadir, and J. V. Weinstock. 1998. Substance P regulates somatostatin expression in inflammation. J. Immunol. 161:6316.