PPARγ ligand inhibits osteopontin gene expression through interference with binding of nuclear factors to A/T-rich sequence in THP-1 cells

Circulation Research

Volumn 90, Issue 3, 2002, Pages 348-355

  Oyama, Yuko ^a   Akuzawa, Nobuhiro ^a   Nagai, Ryozo ^b   Kurabayashi, Masahiko ^a  

^a GUNMA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Macrophage; Osteopontin; Peroxisome proliferator activated receptor; Transcription factors

Indexed keywords

LIGAND; MESSENGER RNA; NUCLEAR FACTOR; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN; TROGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; CELL RECEPTOR; CHROMAN DERIVATIVE; NUCLEAR PROTEIN; SIALOGLYCOPROTEIN; SPP1 PROTEIN, HUMAN; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR;

ADIPOCYTE; ANIMAL CELL; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROTIC PLAQUE; BINDING SITE; CELL DIFFERENTIATION; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; EXTRACELLULAR MATRIX; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIGAND BINDING; MACROPHAGE ACTIVATION; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; RECEPTOR BINDING; WESTERN BLOTTING; ANIMAL; AT RICH SEQUENCE; CELL LINE; CELL STRAIN COS1; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; METABOLISM; MONOCYTE; PHYSIOLOGY; RABBIT; REPORTER GENE; SITE DIRECTED MUTAGENESIS;

ANIMALS; AT RICH SEQUENCE; CELL LINE; CHROMANS; COS CELLS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; HYPOGLYCEMIC AGENTS; LIGANDS; MONOCYTES; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; OSTEOPONTIN; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RABBITS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; SIALOGLYCOPROTEINS; TETRADECANOYLPHORBOL ACETATE; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0037154548     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh0302.105098     Document Type: Article

References (34)

1. The pathogenesis of atherosclerosis: A perspective for the 1990s
2. Molecular bases of the acute coronary syndromes
3. Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence
4. 3 integrin, osteopontin, and thrombin
5. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques
6. Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro
7. Calcification of vascular smooth muscle cell cultures: Inhibition by osteopontin
8. PPAR-γ adipogenic regulator and thiazolidinedione receptor
9. A human peroxisome-proliferator-activated receptor-γ is activated by inducers of adipogenesis, including thiazolidinedione drugs
10. Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor γ
11. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs
12. Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor γ (PPARγ) heterodimers: Intermolecular synergy requires only the PPARγ hormone-dependent activation function
13. The RXR heterodimers and orphan receptors
14. Peroxisome proliferator-activated receptor (PPAR) γ: Adipose-predominant expression and induction early in adipocyte differentiation
15. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
16. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
17. PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
18. Troglitazone, a PPARγ ligand, inhibits osteopontin gene expression in human monocytes/macrophage THP-1 cells
19. A variant derived from rabbit aortic smooth muscle: Phenotype modulation and restoration of smooth muscle characteristics in cells in culture
20. BTEB2, a Krüppel-like transcription factor, regulates expression of the SMemb/nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene
21. Novel elements located at -504 to -399 bp of the promoter region regulated the expression of the human macrophage scavenger receptor gene in murine macrophages
22. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
23. Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells
24. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
25. The PPARs: From orphan receptors to drug discovery
26. Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia
27. Peroxisome proliferator-activated receptor γ activators inhibit gene expression and migration in human vascular smooth muscle cells
28. Macrophages in human atheroma contain PPARγ: Differentiation-dependent peroxisomal proliferator-activated receptor γ (PPARγ) expression and reduction of MMP-9 activity through PPARγ activation in mononuclear phagocytes in vitro
29. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction
30. The role of PPAR-γ in macrophage differentiation and cholesterol uptake
31. Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: Pleiotropic effects on CD36 expression and HDL
32. Inhibition of oxidation of low density lipoprotein by troglitazone
33. Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element
34. Activation of the prolactin gene by peroxisome proliferator-activated receptor-α appears to be DNA binding-independent