Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis

Journal of Medicinal Chemistry

Volumn 41, Issue 23, 1998, Pages 4521-4532

  Shim, Joong Youn ^a   Collantes, Elizabeth R ^a,d   Welsh, William J ^a   Subramaniam, Babu ^b,e   Hewlett, Allyn C ^b   Eissenstat, Michael A ^c,f   Ward, Susan J ^c,g  

^a UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Sanofi Winthrop   (United States)

^d MONSANTO COMPANY   (United States)

^e Palm Beach Neurological Group   (United States)

^f SAIC FREDERICK INC   (United States)

^g WYETH AYERST RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID RECEPTOR; INDOLE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PRAVADOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTON TRANSPORT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CANNABINOIDS; CYCLOHEXANOLS; INDOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; MORPHOLINES; NAPHTHALENES; RADIOLIGAND ASSAY; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032487921     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980305c     Document Type: Article

References (28)

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