Identification of a binding site for ganglioside on the receptor binding domain of tetanus toxin

Biochemistry

Volumn 41, Issue 46, 2002, Pages 13644-13652

  Louch, Heather A ^a   Buczko, Ellen S ^a   Woody, Mary A ^a   Venable, Richard M ^a   Vann, Willie F ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTALLOGRAPHIC STRUCTURES;

AMINO ACIDS; CELL MEMBRANES; HYDROGEN BONDS; MUTAGENESIS; NEUROLOGY; X RAY CRYSTALLOGRAPHY;

BIOCHEMISTRY;

AMINO ACID; ASPARTIC ACID; GALAPTIN; GANGLIOSIDE GD 1B; GANGLIOSIDE GT 1B; HISTIDINE; SIALIC ACID; TETANUS TOXIN; TRYPTOPHAN;

AMINO ACID COMPOSITION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; HYDROGEN BOND; MOLECULAR MODEL; NEURITE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; RECEPTOR BINDING; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CIRCULAR DICHROISM; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; GANGLIOSIDES; HISTIDINE; KINETICS; LIGANDS; LIPOSOMES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PC12 CELLS; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; RATS; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; TETANUS TOXIN;

ANIMALIA; BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 0037137250     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020291j     Document Type: Article

References (28)

1. Herreros, J., Lalli, G., Montecucco, C., and Schiavo, G. (1999) Pathophysiological properties of clostridial neurotoxins. in The Comprehensive Sourcebook of Bacterial Protein Toxins (Alouf, J. E., and Freer, J. H., Eds.) 2nd ed., pp 202-228, Academic Press, San Diego.
2. Lacy, D. B., and Stevens, R. C. (1999) Sequence homology and structural analysis of the clostridial neurotoxins, J. Mol. Biol. 291, 1091-1104.
3. Eisel, U., Jarausch, W., Goretzki, K., Henschen, A., Engels, J., Weller, U., Hudel, M., Habermann, E., and Niemann, H. (1986) Tetanus toxin: Primary structure, expression in E. coli, and homology with botulinum toxins, EMBO J. 5, 2495-2502.
4. Schmidt, J. J., Sathyamoorthy, V., and DasGupta, B. R. (1984) Partial amino acid sequence of the heavy and light chains of botulinum neurotoxin type A, Biochem. Biophys. Res. Commun. 119, 900-904.
5. Schmidt, J. J., Sathyamoorthy, V., and DasGupta, B. R. (1985) Partial amino acid sequences of botulinum neurotoxins types B and E. Arch. Biochem. Biophys. 238, 544-548.
6. c of tetanus neurotoxin, Nat. Struct. Biol. 4, 788-792.
7. Lacy, D. B., Tepp, W., Cohen, A. C., DasGupta, B. R., and Stevens, R. C. (1998) Crystal structure of botulinum neurotoxin type A and implications for toxicity, Nat. Struct. Biol. 5, 898-902.
8. Swaminathan, S., and Eswaramoorthy, S. (2000) Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B, Nat. Struct. Biol. 7, 693-699.
9. Halpern, J. L., Habig, W. H., Neale, E. A., and Stibitz, S. (1990) Cloning and expression of functional fragment C of tetanus toxin, Infect. Immun. 58, 1004-1009.
10. Shapiro, R. E., Specht, C. D., Collins, B. E., Woods, A. S., Cotter, R. J., and Schnaar, R. L. (1997) Identification of a ganglioside recognition domain of tetanus toxin using a novel ganglioside photoaffinity ligand, J. Biol. Chem. 272, 30380-30386.
11. Marxen, P., Fuhrmann, U., and Bigalke, H. (1989) Gangliosides mediate inhibitory effects of tetanus and botulinum A neurotoxins on exocytosis in chromaffin cells, Toxicon 27, 849-859.
12. Williamson, L. C., Bateman, K. E., Clifford, J. C. M., and Neale, E. A. (1999) Neuronal sensitivity to tetanus toxin requires gangliosides, J. Biol. Chem. 274, 25173-25180.
13. Herreros, J., Lalli, G., Montecucco, C., and Schiavo, G. (2000) Tetanus toxin fragment C binds to a protein present in neuronal cell lines and motoneurons, J. Neurochem. 74, 1941-1950.
14. c fragment: Ganglioside binding, cell binding and retrograde axonal transport properties, Mol. Microbiol. 37, 1041-1051.
15. c fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding, J. Biol. Chem. 275, 8889-8894.
16. Kamata, Y., Yoshimoto, M., and Kozaki, S. (1997) Interaction between botulinum neurotoxin type A and ganglioside: Ganglioside inactivates the neurotoxin and quenches its tryptophan fluorescence, Toxicon 35, 1337-1340.
17. Sutton, J. M., Chow-Worn, O., Spaven, L., Silman, N. J., Hallis, B., and Shone, C. C. (2001) Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones, FEBS Lett. 493, 45-49.
18. Varghese, J. N., Smith, P. W., Sollis, S. L., Blick, T. J., Sahasrabudhe, A., McKimm-Breschkin, J. L., and Colman, P. M. (1998) Drug design against a shifting target: A structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase, Structure 6, 735-746.
19. Rutenber, E., and Robertus, J. D. (1991) Structure of ricin B-chain at 2.5 Å resolution, Proteins 10, 260-269.
20. Murzin, A. G., Brenner, S. E., Hubbard, T., and Chothia, C. (1995) SCOP: A structural classification of proteins database for the investigation of sequences and structures, J. Mol. Biol. 247, 536-540.
21. May, A. P., Robinson, R. C., Vinson, M., Crocker, P. R., and Jones, E. Y. (1998) Crystal structure of the N-terminal domain of sialoadhesin in complex with 3′ sialyllactose at 1.85 Å resolution, Mol. Cell 1, 719-728.
22. Brooks, B. R., Bruccoleri, R. E., Olafson, B. D., States, D. J., Swaminathan, S., and Karplus, M. (1983) CHARMM: A program for macromolecular energy, minimization, and dynamics calculations, J. Comput. Chem. 4, 187-217.
23. Merritt, E. A., Sarfaty, S., van den Akker, F., L'Hoir, C., Martial, J. A., and Hol, W. G. J. (1994) Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide, Protein Sci. 3, 166-175.
24. Levitt, M., and Lifson, S. (1969) Refinement ot protein contormations using a macromolecular energy minimization procedure, J. Mol. Biol. 46, 269-279.
25. Gabb, H. A., Jackson, R. M., and Sternberg, M. J. E. (1997) Modelling protein docking using shape complementarity, electrostatics and biochemical information, J. Mol. Biol. 272. 106-120.
26. Quiocho, F. A. (1993) Probing the atomic interactions between proteins and carbohydrates, Biochem. Soc. Trans. 21, 442-448.
27. Fotinou, C., Emsley, P., Black, I., Ando, H., Ishida, H., Kiso, M., Sinha, K. A., Fairweather, N. F., and Isaacs, N. W. (2001) The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin, J. Biol. Chem. 276, 32274-32281.
28. Halpern, J. L., and Loftus, A. (1993) Characterization of the receptor-binding domain of tetanus toxin, J. Biol. Chem. 268, 11188-11192.