Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum

Brain Research

Volumn 879, Issue 1-2, 2000, Pages 42-49

  Bansal, Arvind K ^a   MacTutus, Charles F ^a   Nath, Avindra ^a,b   Maragos, William ^a,b   Hauser, Kurt F ^a   Booze, Rosemarie M ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Astrocytes; Dopamine; GFAP; In vivo; Striatum

Indexed keywords

DOPAMINE; GLYCOPROTEIN GP 120; TATA BINDING PROTEIN; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DEMENTIA; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOADSORPTION; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SYMPTOM;

ANIMALS; CORPUS STRIATUM; GENE PRODUCTS, TAT; GLIAL FIBRILLARY ACIDIC PROTEIN; HIV ENVELOPE PROTEIN GP120; HIV-1; MALE; MICROINJECTIONS; NEURONS; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 0034613407     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02725-6     Document Type: Article

References (45)

1. Aylward E.H., Henderer J.D., McArthur J.C. Reduced basal ganglia volume in HIV-1 associated dementia: results from quantitative neuroimaging. Neurology. 43:1993;2099-2104.
2. Aylward E.H., Brettschneider P.D., McArthur J.C. Magnetic resonance imaging measurement of grey matter volume reductions in HIV dementia. Am. J. Psychiatry. 152:1995;987-994.
3. Bennett B.A., Rusyniak D.E., Hollingsworth C.K. HIV-1 gp120 induced neurotoxicity to midbrain dopamine cultures. Brain Res. 705:1995;168-176.
4. Berger J., Nath A., Greenburg R., Anderson A., Greene R., Bognar A., Avison M. Cerebrovascular changes in the basal ganglia with HIV dementia. Neurology. 54:2000;921-926.
5. Brack-Werner R. Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS. 13:1999;1-22.
6. Cheng J., Nath A., Knudsen B., Hochman S., Geiger J.D., Ma M., Magnuson D.S.K. Neuronal excitatory properties of Human Immunodeficiency Virus type 1 tat protein. Neuroscience. 82:1998;97-106.
7. Cocchi F., DeVico A.L., Garzigo-Demo A., Cara A., Gallo R.C., Lusso P. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nat. Med. 2:(11):1996;1244-1247.
8. Dallasta L.M., Pisarov L.A., Esplen J.E., Werlet J.V., Moses A.V., Nelson J.A., Achim C.L. Blood-brain barrier tight junction disruption in Human Immunodeficiency virus-1 encephalitis. Am. J. Pathol. 155:(6):1999;1915-1927.
9. E.B. Dreyer, S.A. Lipton, Toxic neuronal effects of the HIV coat protein gp120 may be mediated through macrophage arachidonic acid, (Abstract) Society for Neuroscience Abstract, 20 (1994) 1049.
10. Ensoli B., Buonaguro L., Barilarri G., Fiorelli B., Gendelman R. Release, uptake and effects of extracellular human immunodeficiency virus type-1 tat protein on cell growth and viral replication. J. Virol. 67:1993;277-287.
11. Epstein L.G., Gendelman H.E. Human Immunodeficieny Virus type-1 infection of the nervous system: pathogenic mechanisms. Ann. Neurol. 33:1993;429-436.
12. Filippi C.G., Sze G., Farber S.J., Shahmanesh M., Selwyn P.A. Regression of HIV encephalopathy and basal ganglia signal intensity abnormality at MR imaging in patients with AIDS after the initiation of protease inhibitor therapy. Radiology. 206:1998;491-498.
13. Hayman M., Arbuthnott G., Harkiss G., Brace H., Filippi P., Philippon V., Thomson D., Vigne R., Wright A. Neurotoxicity of peptide analogues of the transactivating protein Tat from maedi-visna virus and human immunodeficiency virus. Neuroscience. 53:1993;1-6.
14. 2+ in human neurons and astrocytes. Neuroscience. 91:1999;1369-1378.
15. Hriso E., Kuhn T., Masdeu J.C., Grundman M. Extrapyramidal symptoms due to dopamine blocking agents in patients with AIDS encephalopathy. Am. J. Psychiatry. 48:(11):1991;1558-1561.
16. Hudson L., Liu J., Nath A., Jones M., Raghavan R., Narayan O., Male D., Everall I. Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues. J. Neurovirol. 6:2000;145-155.
17. Lipton S.A. HIV infected macrophages, gp120 and N-methyl-D-aspartate receptor-mediated toxicity. Ann. Neurol. 33:1993;227-228.
18. Lipton S.A. AIDS related dementia and calcium homeostasis. Ann. NY Acad. Sci. 594:1994;189-196.
19. Lopez O.L., Smith G., Meltzer C.C., Becker J.T. Dopamine systems in Human Immunodeficiency Virus-associated Dementia. Neuropsychiatry Neuropsychol. Behav. Neurol. 12:(3):1999;184-192.
20. Magnuson D.S., Knudsen B.E., Geiger J.D., Brownstone R.M., Nath A. Human immunodeficiency virus type1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes toxicity. Ann. Neurol. 37:1995;373-380.
21. Ma M., Nath A. Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells. J. Virol. 71:1997;2495-2499.
22. Ma M., Geiger J.D., Nath A. Characterization of a novel binding site for the human immunodeficiency virus type 1 envelope gp120 on human fetal astrocytes. J. Virol. 68:1994;6824-6828.
23. Mactutus C.F., Herman A.S., Booze R.M. Chronic intravenous model for studies of drug (ab)use in the pregnant and/or group-housed rat: An initial study with cocaine. Neurotoxicol. Teratol. 16:1994;183-191.
24. Martin A., Heyes M.P., Salazar A.M. Impaired motor-skill learning, slowed reaction time, and elevated cerebrospinal fluid quinolinic acid in a subgroup of HIV infected people. Neuropsychology. 7:1993;149-157.
25. McArthur J.C., Selnes O.A., Glass J.D., Hoover D.R., Bacellar H. HIV Dementia. Incidence and Risk Factors. Price R.W., Perry S.W. HIV, AIDS and the Brain. 72:1994;251-272 Raven, New York.
26. Mirsattari S.M., Power C., Nath A. Parkinsonism with HIV infection. Mov. Disord. 13:1998;684-689.
27. Nath A. Pathobiology of Human Immunodeficiency Virus dementia. Semin. Neurol. 19:(2):1999;113-127.
28. Nath A., Conant K., Chen P., Scott C., Major E.O. Transient exposure to HIV-1 tat protein results in cytokine production in macrophages and astrocytes: a hit and run phenomenon. J. Biol. Chem. 274:(24):1999;17098-17102.
29. Nath A., Haughey N.J., Jones M., Anderson C., Bell J.E., Geiger J.D. Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine. Ann. Neurol. 47:2000;186-194.
30. Nath A., Geiger J.D. Neurobiological aspects of HIV infections: neurotoxic mechanisms. Prog. Neurobiol. 54:1998;19-33.
31. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 4th Edition :1998;Academic Press, London.
32. Philippon V., Vellutini C., Gambarelli D., Harkiss G., Arbuthnott G., Metzger D., Roubin R., Filippi P. The basic domain of the lentiviral Tat protein is responsible for damages in mouse brain: Involvement of cytokines. Virology. 205:1994;519-529.
33. Podell M., Maruyama K., Smith M., Hayes K.A., Buck W.R., Ruehlmann D.S., Mathes L.E. Frontal lobe neuronal injury correlates to altered function in FIV-infected cats. J. Acquired Immune Defic. Syndr. 22:(1):1999;10-18.
34. Raghavan R., Stephens E.B., Koag S.V., Adany I., Pinson D.M., Li Z., Jai F., Sahni M., Wang C., Leung K., Foresman L., Narayan O. Neuropathogenesis of chimeric simian/human immunodeficiency virus infection in pig-tailed and rhesus macaques. Brain Pathol. 7:1997;851-861.
35. Ramachandran G., Glickman L., Levenson J., Rao C. Incidence of extrapyramidal syndromes in AIDS patients and a comparison group of medically ill patients. J. Neuropsychiatry Clin. Neurosci. 9:(4):1997;579-583.
36. Sardar A.M., Czudek C., Reynolds G.P. Dopamine deficits in the brain: the neurochemical basis of parkinsonian symptoms in aids. Neuroreport. 7:(4):1996;9-12.
37. Skolnick A.A. Protease inhibitors may reverse AIDS dementia. JAMA (News). 279:1998;419.
38. Smith M.L., Booze R.M. Age related loss of cholinergic and GABAergic neurons in the rat nucleus basalis. Neuroscience. 67:1995;679-688.
39. Stephanie M.T., Elizer M., Edward M.R., Glenn F.R., Carmela R.A., Lennert M. Central Nervous System damage produced by expression of HIV-1 coat protein gp120 in transgenic mice. Nature. 367:1994;188-193.
40. UNAIDS, WHO, AIDS epidemic update: December 1999.
41. Vitkovic L., da Cunha A. Role for astrocytosis in HIV-1 associated dementia. Curr. Top. Microbiol. Immunol. 202:1995;105-116.
42. Weis S., Haug H., Budka H. Astroglial changes in the cerebral cortex of AIDS brains: a morphometric and immunohistochemcial investigation. Neuropath. Appl. Neurobiol. 19:1993;329-335.
43. Wiley C.A., Soontornniyomkij V., Radhakrishnan L., Masliah E., Mellors J., Hermann S.A., Dailey P., Achim C.L. Distribution of brain HIV load in AIDS. Brain Pathol. 8:1998;277-284.
44. Winer B.J. Statistical Principles in Experimental Design. 2nd Edition :1971;McGraw Hill, New York.
45. Zauli G., Secchiero P., Rodella L., Gibellini D., Mirandola P., Mazzoni M., Milani D., Dowd D.R., Capitani S., Vitale M. HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells. J. Biol. Chem. 275:2000;4159-4165.