Dynamics of viral load in plasma and HIV DNA in lymphocytes during highly active antiretroviral therapy (HAART): High viral burden in macrophages after 1 year of treatment

Journal of Chemotherapy

Volumn 13, Issue 2, 2001, Pages 188-194

  Garbuglia, A R ^a   Zaccarelli, M ^a   Calcaterra, S ^a   Cappiello, G ^a   Marini, R ^a   Benedetto, A ^a  

^a NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

Author keywords

CD4+ T cells; HAART; HIV 1; Monocytes

Indexed keywords

ANTIRETROVIRUS AGENT; VIRUS DNA; VIRUS RNA;

ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; LEUKOCYTE COUNT; LYMPHOCYTE; MACROPHAGE; MALE; MONOCYTE; PATIENT MONITORING; TREATMENT OUTCOME; VIRUS LOAD;

EID: 0035054439     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.2001.13.2.188     Document Type: Article

References (28)

1. Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection
2. Rapid turn over of plasma virions and CD4 lymphocytes in HIV-1 infection
3. Report of the NIH Panel to Define Principles of Therapy of HIV Infection and Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents
4. Levels of HIV-infected peripheral blood cells remain stable throughout the natural history of HIV-1 infection
5. Quantification of HIV-1 viral load in lymphoid and blood cells
6. Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure
7. Quantification of integrated and total HIV-1 DNA after long-term highly active antiretroviral therapy in HIV-1-infected patients
8. Decay of HIV-1 DNA in patients receiving suppressive antiretroviral therapy
9. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
10. Decay characteristics of HIV-1 infected compartments during combination therapy
11. Investigation of the dynamics of the spread of human immunodeficiency virus to brain and other tissues by evolutionary analysis of sequences from p17 gag and env genes
12. In vitro activation of HIV RNA expression in peripheral blood lymphocytes as a marker to predict the stability of non progressive status in long-term survivors
13. Biological and biochemical characterization of cloned Leu-3 cell surviving infection with the acquired immunodeficency syndrome retrovirus
14. Human Immunodeficiency Virusinfected individuals contain provirus in small numbers of peripheral mononuclear cells and at low copy number
15. A software tool to extend the quantification power of a virological analysis
16. Identification of reservoir for HIV-1 in patients on highly active antiretroviral therapy
17. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
18. Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy
19. The role of mononuclear phagocytes in HTLV-III/LAV infection
20. Progression of HIV-1 infection. Monitoring of HIV-1 DNA in peripheral blood mononuclear cells by PCR
21. Blood monocytes from most human immunodeficiency virus type 1-infected patients do not carry proviral DNA
22. Latent HIV-1 infection in enriched population of blood monocytes and T cells from seropositive patients
23. HIV-1 in blood monocytes: Frequency of detection of proviral DNA using PCR and comparison with the total CD4 count
24. Macrophages as a source of HIV during opportunistic infections
25. HIV-1 DNA and mRNA concentrations are similar in peripheral blood monocytes and alveolar macrophages in HIV-1-infected individuals
26. Detection of infectious HIV in circulating monocytes from patients on prolonged highly active antiretroviral therapy
27. Relative potency of protease inhibitors in macrophages chronically infected by HIV-1