Whence interferon? Variety in the production of interferon in response to viral infection

Journal of Experimental Medicine

Volumn 195, Issue 4, 2002, Pages

  Levy, David E ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON;

ENHANCER REGION; GENE CLUSTER; HUMAN; NOTE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS REPLICATION;

EID: 0037128165     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020075     Document Type: Note

References (38)

1. Interferons and their actions
2. How cells respond to interferons
3. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
4. Role of early cytokines, including α and β interferons (IFN-α/β), in innate and adaptive immune responses to viral infections
5. Interferon mRNA is produced constitutively in the organs of normal individuals
6. Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes
7. STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-γ
8. A weak signal for strong responses: Interferon-α/β revisited
9. Regulation of inducible and tissue-specific gene expression
10. Enhanceosomes
11. Enhancement and diversification of IFN induction by IRF7-mediated positive Feedback
12. Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3
13. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or IκB kinase but is blocked by vaccinia virus E3L protein
14. Induction of IRF-3/-7 kinase and NF-κB in response to double-stranded RNA and virus infection: Common and unique pathways
15. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: Role of IRF-1 and NF-κB
16. A 46-nucleotide promoter segment from an IFN-α gene renders an unrelated promoter inducible by virus
17. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction
18. Differential viral induction of distinct interferon-α genes by positive feedback through interferon regulatory factor-7
19. Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
20. Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of α/β interferon genes by interferon regulatory factors 3 and 7
21. Human natural interferon-α producing cells
22. The nature of the principal type I interferon-producing cells in human blood
23. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
24. + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells
25. Virus induced interferon-α production by a dendritic cell subset in the absence of feedback signaling in vivo
26. Interferon-α/β and interleukin-12 responses to viral infections: Pathways regulating dendritic cell cytokine expression in vivo
27. Promotion of type I interferon induction during in vivo vital infection through IFN-alpha/beta receptors/STAT1 system dependent and independent pathway
28. Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon α genes
29. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes
30. Lymphotoxins and cytomegalovirus cooperatively induce interferon-β establishing host-virus detente
31. Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection
32. Roles of Toll-like receptors in innate immune responses
33. Regulation of Toll-like receptors in human monocytes and dendritic cells
34. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
35. IFNs activate toll-like receptor gene expression in viral infections
36. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
37. A Toll-like receptor recognizes bacterial DNA
38. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway