Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II

EMBO Journal

Volumn 21, Issue 18, 2002, Pages 4950-4958

  Yang, Jie ^a   Aittomäki, Saara ^a   Pesu, Marko ^a   Carter, Kara ^a   Saarinen, Jussi ^a   Kalkkinen, Nisse ^a   Kieff, Elliott ^a   Silvennoinen, Olli ^a  

^a UNIVERSITY OF TAMPERE   (Finland)

Author keywords

EBV; Interleukin 4; p100 STAT6; Transcription

Indexed keywords

CELL NUCLEUS ANTIGEN; IMMUNOGLOBULIN; INTERLEUKIN 4; PROTEIN P100; RNA POLYMERASE II; STAT6 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BURKITT LYMPHOMA; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL STRAIN COS7; ENZYME SUBUNIT; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CELL FRACTIONATION; CELL LINE; GENES, REPORTER; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RNA POLYMERASE II; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

HUMAN HERPESVIRUS 4;

EID: 0037119969     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf463     Document Type: Article

References (45)

1. Callebaut, I. and Mornon, J.P. (1997) The human EBNA-2 coactivator p 100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development. Biochem. J., 321. 125-132.
2. Chomarat, P. and Banchereau, J. (1997) An update on interleukin-4 and its receptor. Eur. Cytokine Netw., 8, 333-344.
3. Dash, A.B., Orrico, F.C. and Ness, S.A. (1996) The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb. Genes Dev., 10, 1858-1869.
4. Gingras, S., Simard, J., Groner, B. and Pfitzner, E. (1999) p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6. Nucleic Acids Res., 27, 2722-2729.
5. Gires, O. et al. (1999) Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins. EMBO J., 18, 3064-3073.
6. Green, M.R. (2000) TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes. Trends Biochem. Sci., 25, 59-63.
7. Gupta, S., Jiang, M. and Pernis, A.B. (1999) IFN-α activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells J. Immunol., 163, 3834-3841.
8. Hou, J., Schindler, U., Henzel, W.J., Ho, T.C., Brasseur, M. and McKnight, S.L. (1994) An interleukin-4-induced transcription factor: IL-4 Stat. Science, 265, 1701-1706.
9. Johnston, J.A., Kawamura, M., Kirken, R.A., Chen, Y.Q., Blake, T.B., Shibuya, K., Ortaldo, J.R., McVicar, D.W. and O'Shea, J.J. (1994) Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature, 370, 151-153.
10. Kuhn, R., Rajewsky, K. and Muller, W. (1991) Generation and analysis of interleukin-4 deficient mice. Science, 254, 707-710.
11. Leverson, J.D., Koskinen, P.J., Orrico, F.C., Rainio, EM., Jalkanen, K.J., Dash, A.B., Eisenman, R.N. and Ness, S.A. (1998) Pim-1 kinase and p100 cooperate to enhance c-Myb activity. Mol. Cell, 2, 417-425.
12. Lillemeier, B.F., Koster, M. and Kerr, I.M. (2001) STAT1 from the cell membrane to the DNA. EMBO J., 20, 2508-2517.
13. Linja, M.J., Savinainen, K.J., Saramaki, O.R., Tammela, T.L., Vessella, R.L, and Visakorpi, T. (2001) Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer. Cancer Res., 61, 3550-3555.
14. Litterst, C.M. and Pfitzner, E. (2001) Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J. Biol. Chem., 276, 45713-45721.
15. McDonald, C. and Reich, N.C. (1999) Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J. Interferon Cytokine Res., 19, 711-722.
16. Mikita, T., Campbell, D., Wu, P., Williamson, K., and Schindler, U. (1996) Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol., 16. 5811-5820.
17. Mikita, T., Kurama, M. and Schindler, U. (1998) Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP β. J. Immunol., 161, 1822-1828.
18. Moriggl, R. et al. (1997) Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells. Mol. Cell. Biol., 17, 3663-3678.
19. Muchardt, C. and Yaniv, M. (1999) The mammalian SWI/SNF complex and the control of cell growth. Semin. Cell Dev. Biol., 10, 189-195.
20. Nelms, K., Keegan, A.D., Zamorano, J., Ryan, J.J. and Paul, W.E. (1999) The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol., 17, 701-738.
21. Nyman, T.A., Tolo, H., Parkkinen, J. and Kalkkinen, N. (1998) Identification of nine interferon-α subtypes produced by Sendai virus-induced human peripheral blood leucocytes. Biochem. J., 329, 295-302.
22. Orphanides, G., Lagrange, T. and Reinberg, D. (1996) The general transcription factors of RNA polymerase II. Genes Dev., 10, 2657-2683.
23. Paukku, K., Valgeirsdottir, S., Saharinen, P., Bergman, M., Heldin, C.H. and Silvennoinen, O. (2000) Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF β-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases. Biochem. J., 345, 759-766.
24. Pesu, M., Takaluoma, K., Aittomaki, S., Lagerstedt, A., Saksela, K., Kovanen, P.E. and Silvennoinen, O. (2000) Interleukin-4-induced transcriptional activation by stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of stat6. Blood, 95, 494-502.
25. Ponting, C.P. (1997) Tudor domains in proteins that interact with RNA. Trends Biochem. Sci., 22, 51-52.
26. Quelle, F.W. et al. (1995) Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol., 15, 3336-3343.
27. Saharinen, P., Ekman, N., Sarvas, K., Parker, P., Alitalo, K., and Silvennoinen, O. (1997) The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta. Blood, 90, 4341-4353.
28. Saharinen, P., Takaluoma, K. and Silvennoinen, O. (2000) Regulation of the Jak2 tyrosine kinase by its pseudokinase domain. Mol. Cell. Biol., 20, 3387-3395.
29. Shang, Y., Hu, X., DiRenzo, J., Lazar, M.A. and Brown, M. (2000) Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell, 103, 843-852.
30. Shankaranarayanan, P., Chaitidis, P., Kuhn, H. and Nigam, S. (2001) Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15- lipoxygenase-1 gene. J. Biol. Chem., 276, 42753-42760.
31. Shen, C.H. and Stavnezer, J. (1998) Interaction of stat6 and NF-κB: direct association and synergistic activation of interleukin-4-induced transcription. Mol. Cell. Biol., 18. 3395-3404.
32. Shen, Y. and Darnell, J.E., Jr (2001) Antiviral response in cells containing Stat1 with heterologous transactivation domains. J. Virol., 75, 2627-2633.
33. Shimoda, K. et al. (1996) Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 380, 630-633.
34. Shuai, K. (2000) Modulation of STAT signaling by STAT-interacting proteins. Oncogene, 19, 2638-2644.
35. Stutz, A.M. and Woisetschlager, M. (1999) Functional synergism of STAT6 with either NF-κB or PU. 1 to mediate IL-4-induced activation of IgE germline gene transcription. J. Immunol., 163, 4383-4391.
36. Thienes, C.P., De Monte, L., Monticelli, S., Busslinger, M., Gould, H.J. and Vercelli, D. (1997) The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4- and CD40-mediated activation of the human epsilon germline promoter. J. Immunol., 158, 5874-5882.
37. Tinnell, S.B., Jacobs-Helber, S.M., Sterneck, E., Sawyer, S.T. and Conrad, D.H. (1998) STAT6, NF-κB and C/EBP in CD23 expression and IgE production. Int. Immunol., 10, 1529-1538.
38. Tong, X., Drapkin, R., Yalamanchili, R., Mosialos, G. and Kieff, E. (1995) The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. Mol. Cell. Biol., 15, 4735-4744
39. Torchia, J., Rose, D.W., Inostroza, J., Kamei, Y., Westin, S., Glass, C.K, and Rosenfeld, M.G. (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature. 387, 677-684.
40. Wang, F., Gregory, C., Sample, C., Rowe, M., Liebowitz, D., Murray, R., Rickinson, A. and Kieff, E. (1990) Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. J. Virol., 64, 2309-2318.
41. Wang, L., Grossman, S.R. and Kieff, E. (2000) Epstein-Barr virus nuclear protein 2 interacts with p300, CBP and PCAF histone acetyltransferases in activation of the LMP1 promoter. Proc. Natl Acad. Sci. USA, 97, 430-435.
42. Witthuhn, B.A., Silvennoinen, O., Miura, O., Lai, K.S., Cwik, C., Liu, E.T. and Ihle, J.N. (1994) Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature, 370, 153-157.
43. Xu, L., Glass, C.K. and Rosenfeld, M.G. (1999) Coactivator and corepressor complexes in nuclear receptor function. Curr. Opin. Genet. Dev., 9, 140-147.
44. Zhang, J.J., Vinkemeier, U., Gu, W., Chakravarti, D., Horvath, C.M. and Darnell, J.E., Jr (1996) Two contact regions between Stat1 and CBP/p300 in interferon γ signaling. Proc. Natl Acad. Sci. USA, 93, 15092-15096.
45. Zhang, J.J., Zhao, Y., Chait, B.T., Lathem, W.W., Ritzi, M., Knippers, R. and Darnell, J.E., Jr (1998) Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation. EMBO J., 17, 6963-6971.