Role of vascular endothelial growth factor in neuronal DNA damage and repair in rat brain following a transient cerebral ischemia

Journal of Neuroscience Research

Volumn 70, Issue 2, 2002, Pages 140-149

  Yang, Zeng Jin ^a   Bao, Wei Li ^a   Qiu, Mei Hong ^a   Zhang, Ling Mei ^a   Lu, Shi Duo ^a   Huang, Ya Lin ^a   Sun, Feng Yan ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Brain; DNA repair; Ischemia; Vascular endothelial growth factor

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MESSENGER RNA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL COUNT; CELL DAMAGE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA HELICASES; DNA REPAIR; ENDOTHELIAL GROWTH FACTORS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISCHEMIC ATTACK, TRANSIENT; LYMPHOKINES; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0037107975     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10380     Document Type: Article

References (37)

1. Bao WL, Lu SD, Wang H, Sun FY. 1999. Intraventricular vascular endothelial growth factor antibbody increases infarct volume following transient cerebral ischemia. Acta Pharmacol Sin 20:313-318.
2. Chen J, Jin K, Chen M, Pei W, Kawaguchi K, Greenberg DA, Simon RP. 1997. Early detection of DNA strand breaks in the brain after transient focal ischemia: implications for the role of DNA damage in apoptosis and neuronal death. J Neurochem 69:232-245.
3. Chen J, Simon RP, Nagayama T, Zhu R, Loeffert JE, Watkins SC, Graham SH. 2000. Suppression of endogenous bcl-2 expression by antisense treatment exacerbates ischemic neuronal death. J Cereb Blood Flow Metab 20:1033-1039.
4. Chopp M, Chan PH, Hsu CY, Cheung ME, Jacobs TP. 1996. DNA damage and repair in central nervous system injury: national institute of neurological disorders and stroke workshop summary. Stroke 27:363-369.
5. Cobbs CS, Chen J, Greenberg DA, Graham SH. 1998. Vascular endothelial growth factor expression in transient focal cerebral ischemia in the rat. Neurosci Lett 249:79-82.
6. Dvorak HF, Brown LF, Detmar M, Dvorak AM. 1995. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis. Am J Pathol 146:1029-1039.
7. Ginsberg MD, Busto R. 1989. Rodent models of cerebral ischemia. Stroke 20:1627-1642.
8. Hayashi T, Abe K, Itotama Y. 1998. Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia. J Cereb Blood Flow Metab 18:887-895.
9. Hayashi T, Abe K, Suzuki H, Itoyama Y. 1997. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke 28:2039-2044.
10. Issa R, Krupinski J, Bujny T, Kumar S, Kaluza J, Kumar P. 1999. Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke. Lab Invest 79:417-425.
11. Jin KL, Mao XO, Greenberg DA. 2000a. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc Natl Acad Sci USA 97:10242-10247.
12. Jin KL, Mao XO, Nagayama T, Goldsmith PC, Greenberg DA. 2000b. Induction of vascular endothelial growth factor and hypoxia-inducible factor-1α by global ischemia in rat brain. Neuroscience 99:577-585.
13. Jin KL, Mao XO, Nagayama T, Goldsmith PC, Greenberg DA. 2000c. Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3′-kinase/Akt signaling by global cerebral ischemia in the rat. Neuroscience 100:713-717.
14. Jin K, Mao XO, Batteur SP, McEachron E, Leahy A, Greenberg DA. 2001. Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor. Neuroscience 108:351-358.
15. Kovacs Z, Ikezaki K, Samoto K, Inamura T, Fukui M. 1996. VEGF and flt expression time kinetics in rat brain infarct. Stroke 27:1865-1872.
16. Kuroki M, Voest EE, Amano S, Beerepoot LV, Takashima S, Tolentino M, Kim RY, Rohan RM, Colby KA, Yeo KT, Adamis A. 1996. Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo. J Clin Invest 98:1667-1675.
17. Lennmyr F, Ata KA, Funa K, Olsson Y, Terent A. 1998. Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat. J Neuropathol Exp Neurol 57:874-882.
18. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. 1989. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306-1309.
19. Levy AP. 1998. Hypoxic regulation of VEGF mRNA stability by RNA-binding proteins. Trends Cardiovasc Med 8:246-250.
20. Li Y, Chopp M, Jiang N, Yao F, Zaloga C. 1995. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 15:389-397.
21. Ling X, Zhang LM, Huang YL, Bao WL, Sun FY. 1999a. Neuronal ERCC6 mRNA expression in rat brain induced by a transient focal cerebral ischemia. Acta Pharmacol Sin 20:15-20.
22. Ling X, Zhang LM, Lu SD, Li XJ, Sun FY. 1999b. Protective effect of melatonin on injured cerebral neurons is associated with bcl-2 protein over-expression. Acta Pharmacol Sin 20:409-414.
23. Lipton P. 1999. Ischemic cell death in brain neurons. Physiol Rev 79:1431-1568.
24. Longa EZ, Weuinstein PR, Carlson S, Cummins R. 1989. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91.
25. Masood R, Cai J, Zheng T, Smith DL, Naidu Y, Gill PS. 1997. Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kapoosi sarcoma. Proc Natl Acad Sci USA 94:979-984.
26. Orren DK, Dianov GL, Bohr VA. 1996. The human CSB (ERCC6) gene corrects the transcription-couple repair defect in the CHO cell mutant UV61. Nucleic Acids Res 24:3317-3322.
27. Paxinos G, Watson C. 1986. The rat brain in stereotaxic coordinates, 2nd ed. Orlando, FL: Academic press.
28. Plate KH, Beck H, Danner S, Allegrinni PR, Wiessner C. 1999. Cell type specific upregulation of vascular endothelial growth factor in an MCA occlusion model of cerebral infarct. J Neuropathol Exp Neurol 58:654-666.
29. Romashkova JA, Makarov SS, 1999. NF-kappaB is a target of AKT in anti-apoptotic PDGF signaling. Nature 401:86-90.
30. Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA, Wang Y, Schielke JP, Welty DF. 1996. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16:675-686.
31. Satake S, Kuzuya M, Miura H, Asai T, Ramos MA, Muraguchi M, Ohmoto Y, Iguchi A. 1998. Up-regulation of vascular endothelial growth factor in response to glucose deprivation. Biol Cell 90:161-168.
32. Slevin M, Krupinski J, Slowik A, Kumar P, Szczudlik A, Gaffney J. 2000. Serial measurement of vascular endothelial growth factor and transforming growth factor-betal in serum of patients with acute ischemic stroke. Stroke 31:1863-1870.
33. Sun FY, Lin X, Mao LZ, Ge WH, Zhang LM, Huang YL. 2002. Neuroprotection by melatonin against ischemic neuronal injury associated with modulation of DNA damage and repair in the rat following a transient cerebral ischemia. J Pineal Res (in press).
34. Tao F, Lu SD, Zhang LM, Huang YL, Sun FY. 2001. Role of excitatory amino acid transporter 1 in neonatal rat neuronal damage induced by hypoxia-ischemia. Neuroscience 102:503-513.
35. Troelstra C, Odijk H, de Wit J, Westerveld A, Thompon LH, Bootsma D, Hoeijmakers JH. 1990. Molecular cloning of the human DNA excision repair gene ERCC6. Mol Cell Biol 10:5806-5813.
36. Weiss B, Davidkova G, Zhang SP. 1997. Antisense strategies in neurobiology. Neurochem Int 31:321-348.
37. Yin KJ, Sun FY. 1999. Effect of dextromethorphan, a NMDA antagonist, on DNA repair in rat photochemical thrombotic cerebral ischemia. Brain Res 815:29-35.