Regional fat metabolism in human splanchnic and adipose tissues; the effect of exercise

Journal of Physiology

Volumn 543, Issue 3, 2002, Pages 1033-1046

  Van Hall, Gerrit ^a,c   Bülow, Jens ^b   Sacchetti, Massimo ^a   Al Mulla, Nariman ^b   Lyngsø, Dorthe ^b   Simonsen, Lene ^b  

^a Mental Health Services CPH   (Denmark)

^b BISPEBJERG HOSPITAL   (Denmark)

^c Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLYCEROL DERIVATIVE; PALMITIC ACID DERIVATIVE; TRIACYLGLYCEROL; GLYCEROL; PALMITATE C 13; RADIOISOTOPE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ARTERY CATHETER; CONTROLLED STUDY; ESTERIFICATION; EXERCISE; FATTY ACID METABOLISM; HEPATIC VEIN; HUMAN; HUMAN EXPERIMENT; LIPID TRANSPORT; NORMAL HUMAN; PRIORITY JOURNAL; RADIAL ARTERY; REVIEW; SPLANCHNIC BLOOD FLOW; ADULT; ARTICLE; EXERCISE RECOVERY; FATTY ACID TRANSPORT; HUMAN TISSUE; LIVER VEIN; MALE; REESTERIFICATION; SUBCUTANEOUS VEIN; VEIN;

3-HYDROXYBUTYRIC ACID; ABDOMEN; ACETATES; ADIPOSE TISSUE; ADULT; CARBON ISOTOPES; DEUTERIUM; ESTERIFICATION; EXERCISE; FATTY ACIDS; GLYCEROL; HUMANS; LIVER; MALE; PALMITATES; REGIONAL BLOOD FLOW; SPLANCHNIC CIRCULATION; TRIGLYCERIDES;

EID: 0037106408     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.022392     Document Type: Review

References (41)

1. Ahlborg, G., Gelig, P., Hagenfeldt, L., Hendler, R. & Wahren, J. (1974). Substrate turnover during prolonged exercise in mansplanchnic and leg metabolism of glucose, free fatty acids, and amino acids. Journal of Clinical Investigations 53, 1080-1090.
2. Boberg, J., Carlson, L. A. & Freyschuss, U. (1972). Determination of splanchnic turnover of plasma fatty acids in man. European Journal of Clinical Investigations 2, 123-132.
3. Bl̈ow, J. (2001). Measurement of adipose tissue blood flow. Methods in Molecular Biology 155, 281-293.
4. Bülow, J., Jelnes, R., Atrup, A. & Madsen, J. V. P. (1987). Tissue/blood partition coefficients for xenon in various adipose tissue in man. Scandinavian Journal of Clinical and Laboratory Investigations 47, 1-3.
5. Bülow, J., Simonsen, L., Wiggins, D., Humphreys, S. M., Frayn, K. N., Powell, D. & Gibbons, G. F. (1999). Co-ordination of hepatic and adipose tissue lipid metabolism after oral glucose. Journal of Lipid Research 40, 2034-2043.
6. Campbell, P. J., Carlson, M. G., Hill, J. O. & Nurjhan, N. (1992). Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. American Journal of Physiology 263, E1063-1069.
7. Coppack, S. W., Frayn, K. N., Humphreys, S. M., Whyte, P. L. & Hockaday, D. R. (1990). Arteriovenous differences across human adipose and forearm tissues after overnight fast. Metabolism. 39, 384-390.
8. Coppack, S. W., Persson, M., Judd, R. L. & Miles, J. M. (1999). Glycerol and nonesterified fatty acid metabolism in human muscle and adipose tissue in vivo. American Journal of Physiology 276, E233-240.
9. Diraison, F. & Beylot, M. (1998). Role of human liver lipogenesis and reesterification in triglycerides secretion and FFA reesterification. American Journal of Physiology 274, E321-327.
10. Frayn, K. N., Coppack, S. W., Fielding, B. A. & Humpreys, S.M. (1995). Coordinated regulation of hormone-sensitive lipase and lipoproteinlipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. Advances in Enzyme Regulation 35, 163-178.
11. Folch, J., Lees, M. & Stanley, G. H. (1957). A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 226, 497-510.
12. Frayn, K. N., Fielding, B. A., Samra, J. S. & Summers, L. K. M. (eds) (1997). Extracellular Metabolic Regulation in Adipose Tissue. Physiology, Stress and Malnutrition. Functional Correlates, Nutritional Intervention. Lippincott-Raven Publishers, Philadelphia.
13. Guo, Z. & Jensen, M. D. (1999). Blood glycerol is an important precursor for intramuscular triacylglycerol synthesis. Journal of Biological Chemistry 274, 23702-23706.
14. Havel, R. J. Balasse, E. O., Segel, N. & Basso, L. V. (1970). Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normoxtriglyceridemic and hypotriglyceridemic humans. Journal of Clinical Investigations 49, 2017-2035.
15. Henriksen, J. H. & Winkler, K. (1987). Hepatic blood flow determination. A comparison of 99-Tc-diethyl-IDA and indocyanine green as hepatic blood flow indicator in man. Journal of Hepatology 4, 66-70.
16. Jensen, M. D. (1995). Gender difference in regional fatty acid metabolism before and after meal ingestion. Journal of Clinical Investigations 96, 2297-2303.
17. Jensen, M. D. (1999). Regional and free fatty acid metabolism before and after meal ingestion. American Journal of Physiology 276, E863-869.
18. Jensen, M. D., Ekberg, K. & Landau, B. R. (2001). Lipid metabolism during fasting. American Journal of Physiology Endocrinology and Metabolism 281, E789-793.
19. Kanno, T. & Maekawa, M. (1995). Lactate dehydrogenase M-subunit deficiencies: clinical features, metabolic background, and genetic heterogeneities. Muscle and Nerve, suppl. 3, 54S-60S.
20. Kurpad, A., Khan, K., Calder, A. G., Coppack, S., MacDonald, I. & Elia, M. (1994). Effect of noradrenaline on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clinical Science 86, 177-184.
21. Landau, B. R., Wahren, J., Previs, S. F., Ekberg, K., Chandramouli, V. & Brunengraber, H. (1996). Glycerol production and utilization in humans: sites and quatitation. American Journal of Physiology 271, E1110-1117.
22. Mittendorfer, B., Sidossis, L. S., Walser, E., Chinkes, D. L. & Wolfe, R. R. (1998). Regional acetate kinetics and oxidation in human volunteers. American Journal of Physiology 274, E978-983.
23. Miyajima, H., Takahashi, Y. & Kaneko, E. (1995). Characterization of the glycolysis in lactate dehydrogenase-A deficiency. Muscle and Nerve 18, 874-878.
24. Mulla, N. A., Simonsen, L. & Bülow, J. (2000). Post-exercise adipose tissue and skeletal muscle lipid metabolism in humans: effect of exercise intensities. Journal of Physiology 524, 919-928.
25. Newsholme, E. A. & Crabtree, B. (1976). Substrate cycles in metabolic regulation and in heat generation. Biochemistry Society Symposium 41, 61-109.
26. Romijn, J.A., Klein, S., Coyle, E. F., Sidossis, L. S. & Wolfe, R. R. (1993). Strenuous endurance training increases lipolysis and triglycride-fatty acid cycling at rest. Journal of Applied Physiology 75, 108-113.
27. Ryall, R. L. & Goldrick, R. B. (1977). Glycerol kinase in human adipose tissue. Lipids 12, 272-277.
28. Sacchetti, M., Saltin, B., Osada, T. & van Hall, G. (2002). Intramuscular fatty acid metabolism in contracting and non-contracting human skeletal muscle. Journal of Physiology 540, 387-395.
29. Samra, J.S., Clark, M. L., Humpreys, S. M., Bannister, P. A., Summers, L. K. M., MacDonald, I. A. & Frayn, K. N. (1999). Evidence for glycerol uptake by subcutaneous adipose tissue. Proceedings of the Nutritional Society 58, 164A.
30. Seltzer, W. K., Angelini, C., Dhariwal, G., Ringel, S. P. & McCabe, E. R. B. (1989). Muscle glycerol kinase in Duchenne dystrophy and glycerol kinase deficiency. Muscle and Nerve 12, 307-313.
31. Sidossis, L. S., Coggan, A. R., Gastadelli, A. & Wolfe, R. R. (1995). A new correction factor for use in a tracer estimations of plasma fatty acid oxidation. American Journal of Physiology 269, E649-656.
32. Sidossis, L. S., Mittendorfer, B., Chinkes, D., Walser, E. & Wolfe, R. R. (1999). Effect of hyperglycemia-hyperinsulimia on whole body and regional fatty acid metabolism. American Journal of Physiology 276, E427-434.
33. Sidossis, L. S., Mittendorfer, B., Walser, E., Chinkes, D. & Wolfe, R. R. (1998). Hyperglycemia-induced inhibition of splanchnic fatty acid oxidation increases hepatic triacylglycerol secretion. American Journal of Physiology 275, E798-805.
34. Simonsen, L., Bülow, J. & Madsen, J. (1994). Adipose tissue metabolism in humans determined by vein catherization and microdialysis techniques. American Journal of Physiology 266, E357-365.
35. Steele, R. (1959). Influences of glucose loading and of injected insulin on hepatic glucose output. Annals of the New York Academy of Medical Sciences 82, 420-430.
36. Thomas, E. L., Saeed, N., Hajnal, J. V., Brynes, A., Goldstone, A. P., Frost, G. & Bell, J. D. (1998). Magnetic resonance imaging of total body fat. Journal of Applied Physiology 85, 1778-1785.
37. van Hall, G., (1999). Correction factors for 13C-labelled substrate oxidation at whole-body and muscle level. Proceedings of the Nutritional Society 58, 979-986.
38. van Hall, G., Sacchetti, M., Radegran, G., & Saltin, B. (2002). Human skeletal muscle fatty acid and glycerol metabolism during rest, exercise and recovery. Journal of Physiology 543, 1047-1058.
39. Wahren, J., Sato, Y., Östman, J., Hagenfeldt, L. & Felig, P. (1984). Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise. Journal of Clinical Investigations 73, 1367-1376.
40. Wolfe, R. R. (1992). Radioactive and Stable Isotopes Tracers in Biomedicine. Principles and Practice of Kinetic Analysis. Wiley-Liss, Inc., New York.
41. Wolfe, R. R., Klein, S., Carraro, F. & Weber, J.-M. (1990). Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise. American Journal of Physiology 258, E382-389.