Regional acetate kinetics and oxidation in human volunteers

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 6 37-6, 1998, Pages

  Mittendorfer, B ^a   Sidossis, L S ^a,b   Walser, E ^a   Chinkes, D L ^a   Wolfe, R R ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

Acetate correction factor; Fatty acids; Liver; Muscle

Indexed keywords

ACETIC ACID; CARBON; CARBON DIOXIDE;

ADULT; ARTICLE; CARBON DIOXIDE EXCRETION; CHEMICAL REACTION KINETICS; EXTRACTION; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; LIVER METABOLISM; MALE; NORMAL HUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; STEADY STATE;

EID: 0031859472     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.6.e978     Document Type: Article

References (17)

1. Bleiberg, B., T. R. Beers, M. Persson, and J. M. Miles. Systemic and regional acetate kinetics in dogs. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E197-E202, 1992.
2. Bleiberg, B., T. R. Beers, M. Persson, and J. M. Miles. Metabolism of triacetin-derived acetate in dogs. Am. J. Clin. Nutr. 58: 908-911, 1993.
3. Chinkes, D. L., X. J. Zhang, J. A. Romijn, Y. Sakurai, and R. R. Wolfe. Measurement of pyruvate and lactate kinetics across the hindlimb and gut of anesthetized dogs. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E174-E182, 1994.
4. Coppack, S. W., K. N. Frayn, S. M. Humphreys, P. L. Whyte, and D. R. Hockaday. Arteriovenous differences across human adipose and forearm tissues after overnight fast. Metabolism 39: 384-390, 1990.
5. Hellerstein, M. K., M. Christiansen, S. Kaempfer, C. Kletke, K. Wu, J. S. Reid, K. Mulligan, N. S. Hellerstein, and C. H. Shackleton. Measurement of de novo hepatic lipogenesis in humans using stable isotopes. J. Clin. Invest. 87: 1841-1852, 1991.
6. Knowles, S. E., I. G. Jarrett, O. H. Filsell, and F. J. Ballard. Production and utilization of acetate in mammals. Biochem. J. 142: 401-411, 1974.
7. Persson, M., B. Bleiberg, D. Kiss, and J. Miles. Measurement of plasma acetate kinetics using high-performance liquid cromatography. Anal. Biochem. 198: 149-153, 1991.
8. Pomare, E. W., W. J. Branch, and J. H. Cummings. Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood. J. Clin. Invest. 75: 1448-1454, 1985.
9. 13C]acetate. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E58-E64, 1996.
10. Powers, L., M. K. Osborn, D. Yang, C. L. Kien, R. D. Murray, M. Beylot, and H. Brunengraber. Assay of the concentration and stable isotope enrichment of short-chain fatty acids by gas-chromatography/mass spectrometry. J. Moss Spectrum. 30: 747-754, 1995.
11. Scheppach, W., E. W. Pomare, M. Elia, and J. H. Cummings. The contribution of the large intestine to blood acetate in man. Clin. Sci. (Colch.) 80: 177-182, 1991.
12. 14C-acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis. J. Biol. Chem. 266: 6985-6990, 1991.
13. Sidossis, L. S., A. R. Coggan, A. Gastaldelli, and R. R. Wolfe. A new correction factor for use in tracer estimations of plasma fatty acid oxidation. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E649-E656, 1995.
14. Sidossis, L. S., C. A. Stuart, G. I. Shulman, G. D. Lopaschuk, and R. R. Wolfe. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J. Clin. Invest. 98: 2244-2250, 1996.
15. Simoneau, C., E. Pouteau, P. Maugeais, L. Marks, S. Ranganathan, M. Champ, and M. Krempf. Measurement of whole body acetate turnover in healthy subjects with stable isotopes. Biol. Mass Spectrom. 23: 430-433, 1994.
16. Skutches, C. L., C. P. Holroyde, R. N. Myers, P. Paul, and G. A. Reichard. Plasma acetate turnover and oxidation. J. Clin. Invest. 64: 708-713, 1979.
17. 2 during the infusion of C-1 vs C-2-labeled acetate: implications for tracer studies of substrate oxidation. Am. J. Clin. Nutr. 51: 248-252, 1992.