Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells

Journal of Immunology

Volumn 169, Issue 6, 2002, Pages 3120-3130

  Sharma, Sonia ^a   Grandvaux, Nathalie ^a   Mamane, Yael ^a   Genin, Pierre ^a   Azimi, Nazli ^a   Waldmann, Thomas ^a   Hiscott, John ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM IONOPHORE; CD28 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 4; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PROTEIN P50; SYNAPTOTAGMIN; T LYMPHOCYTE RECEPTOR; TAX PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR REL;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; GENE EXPRESSION REGULATION; GENE MUTATION; GENE TARGETING; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LYMPHOCYTE TRANSFORMATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; T LYMPHOCYTE; TRANSACTIVATION; TRANSCRIPTION REGULATION; VIRUS INFECTION;

EID: 0037105515     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.6.3120     Document Type: Article

References (62)

1. Interferon regulatory factors: The next generation
2. Irf family of transcription factors as regulators of host defense
3. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
4. Regulated expression of a gene encoding a nuclear factor. IRF-1, that specifically binds to IFN-β gene regulatory elements
5. Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription
6. An interferon γ-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class 1 genes
7. How cells respond to interferons
8. Type I interferons: Expression and signalization
9. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator
10. Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)
11. A novel interferon regulatory factor family transcription factor. ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes
12. Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages
13. Interferon consensus sequence binding protein and interferon regulatory factor-4/Pip form a complex that represses the expression of the interferon-stimulated gene-15 in macrophages
14. PU.1/interferon regulatory factor interactions: mechanisms of transcriptional regulation
15. Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4
16. Activation and regulation of interferon regulatory factor 4 in HTLV type 1-infected T lymphocytes
17. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression
18. Repression of IRF-4 target genes in human T cell leukemia virus-1 infection
19. T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor
20. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis
21. Infection and transformation of fresh human umbilical cord blood cells by multiple sources of human T-cell leukemia-lymphoma virus (HTLV)
22. Stable expression of the tax gene of type I human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth
23. Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia
24. Regulation of gene expression by HTLV-I Tax protein
25. Regulation of human T cell leukemia virus expression
26. Persistent activation of NF-κB by the tax transforming protein of HTLV-1: Hijacking cellular IκB kinases
27. Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25
28. Site-directed mutagenesis by overlap extension using the polymerase chain reaction
29. Disruption of NF-κB signaling reveals a novel role for NF-κB in the regulation of TNF-related apoptosis-inducing ligand expression
30. Identification of HTLV-I tax transactivator mutants exhibiting novel transcriptional phenotypes
31. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-κB/Rel transcription factors
32. Identification by in vivo genomic footprinting of a transcriptional switch containing NF-κB and Sp1 that regulates the IκBα promoter
33. In vivo footprinting of a muscle specific enhancer by ligation mediated PCR
34. Effects of different DNA polymerases in ligation-mediated PCR: Enhanced genomic sequencing and in vivo footprinting
35. Inducible expression of IκBα repressor mutants interferes with NF-κB activity and HIV-I replication in Jurkat T cells
36. c-Myc target gene specificity is determined by a post-DNA binding mechanism
37. Persistent activation of NF-κB by the tax transforming protein involves chronic phosphorylation of IκB kinase subunits IKKβ and IKKγ
38. Role of adapter function in oncoprotein-mediated activation of NF-κB: Human T-cell leukemia virus type I Tax interacts directly with IκB kinase γ
39. Transcription factors of the NFAT family: Regulation and function
40. Contingent genetic regulatory events in T lymphocyte activation
41. Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT
42. Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NFAT1, in tax-expressing and type I human T cell leukemia-virus-infected human T cells
43. Activation of the IL-2 gene promoter by HTLV-1 tax involves induction of NF-AT complexes bound to the CD28-responsive element
44. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites
45. Nuclear factor of activated T cells contributes to the function of the CD28 response region of the granulocyte macrophage-colony stimulating factor promoter
46. Identification of a CD28 response element in the CD40 ligand promoter
47. Requirements for interleukin 2 promoter transactivation by the Tax protein of human T-cell leukemia virus type 1
48. Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: Modulation of interferon-regulated gene expression by rel/nuclear factor κB
49. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28
50. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation
51. Activation of nuclear factor of activated T cells in a cyclosporin A-resistant pathway
52. Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells
53. Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-κB site
54. tax protein in the human T-cell line
55. Involvement of NF-AT in type I human T-cell leukemia virus Tax-mediated Fas ligand promoter transactivation
56. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering
57. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I
58. How does interleukin 15 contribute to the pathogenesis of HTLV type I-associated myelopathy/tropical spastic paraperesis?
59. IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients
60. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
61. Deregulation of MUMI/IRF4 by chromosomal translocation in multiple myeloma
62. MUMI/IRF4 expression as a frequent event in mature lymphoid malignancies