Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of fanconi anemia complementation group C cells to interferon γ, tumor necrosis factor-α, and double-stranded RNA

Blood

Volumn 97, Issue 6, 2001, Pages 1644-1652

  Pang, Qishen ^b   Keeble, Winifred ^b   Diaz, Jane ^b   Christianson, Tracy A ^b   Fagerlie, Sara ^b   Rathbun, Keaney ^b   Faulkner, Gregory R ^b   O'Dwyer, Michael ^b   Bagby Jr , Grover C ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; GAMMA INTERFERON; I KAPPA B; INITIATION FACTOR; MESSENGER RNA; PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CROSS LINKING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FANCONI ANEMIA; GENE OVEREXPRESSION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HYPERSENSITIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA BINDING; SIGNAL TRANSDUCTION; TRANSLATION INITIATION;

EID: 0035869495     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.6.1644     Document Type: Article

References (44)

1. Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells
2. -/- mice
3. Interferon-γ-induced apoptotic responses of Fanconi anemia group C hematopoietic progenitor cells involve caspase 8-dependent activation of caspase 3 family members
4. Tumor necrosis factor-alpha and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice
5. Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
6. Jaks and Stats in signaling by the cytokine receptor superfamily
7. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
8. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by IFN-γ and hematopoietic growth factors
9. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling
10. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
11. PKR: A sentinel kinase for cellular stress
12. IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR
13. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase
14. Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB
15. Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B
16. Hypersensitivity to oxygen is a uniform and secondary defect in Fanconi anemia cells
17. Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-dependent protein kinase (PKR) and differences from its mouse homolog
18. Improved retroviral vectors for gene transfer and expression
19. Cloning of cDNAs for Fanconi's anaemia by functional complementation
20. Ping-pong amplification of a retroviral vector achieves high-level gene expression: Human growth hormone production
21. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
22. Specific repression of granulocyte-macrophage and granulocyte colony-stimulating factor gene expression in interleukin-1-stimulated endothelial cells with antisense oligodeoxynucleotides
23. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
24. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: Role of IRF-1 and NF-kappaB
25. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
26. The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases
27. The Fanconi anemia group C gene product modulates apoptotic responses to tumor necrosis factor-alpha and Fas ligand but does not suppress expression of receptors of the tumor necrosis factor receptor superfamily
28. MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups
29. Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis
30. Suppression of steady state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis
31. Translational control in mammalian cells
32. Studies of interferon as a regulator of hematopoietic cell proliferation
33. The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: Synergism of tumor necrosis factor and interferon-gamma
34. Interferon-induced proteins are elevated in blood samples of patients with chemically or virally induced chronic fatigue syndrome
35. The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis
36. An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells
37. Mechanism of interferon action: Evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein
38. Abrogation of translation initiation factor elF-2 phosphorylation causes malignant transformation of NIH 3T3 cells
39. Inhibition of interferon regulatory factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of Stat1 and Stat3
40. waf1
41. Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex
42. The molecular chaperone hsp40 regulates the activity of P581PK, the cellular inhibitor of PKR
43. Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P581PK inhibitor
44. Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: Involvement of RNase L, protein kinase R, and alternative pathways