FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-γ/TNF-α-mediated cytotoxicity

EMBO Journal

Volumn 20, Issue 16, 2001, Pages 4478-4489

  Pang, Qishen ^a,b   Keeble, Winifred ^b   Christianson, Tracy A ^b   Faulkner, Gregory R ^b   Bagby, Grover C ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

FANCC; Fanconi anemia; Hsp70 IFN and TNF cytotoxicity; Protective function

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; CHAPERONE; FANCONI ANEMIA COMPLEMENTATION GROUP C GENE PRODUCT; GAMMA INTERFERON; GENE PRODUCT; HEAT SHOCK PROTEIN 70; PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; FANCONI ANEMIA; HELA CELL; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATASES; APOPTOSIS; BINDING SITES; CELL CYCLE PROTEINS; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; DNA-BINDING PROTEINS; EIF-2 KINASE; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP C PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS; GLUTATHIONE TRANSFERASE; HEAT-SHOCK PROTEINS; HELA CELLS; HSP40 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INTERFERON-GAMMA, RECOMBINANT; NUCLEAR PROTEINS; PROTEINS; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035881864     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.16.4478     Document Type: Article

References (56)

1. Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex
2. Leukemia and preleukemia in Fanconi anemia patients. A review of the literature and report of the International Fanconi Anemia Registry
3. Hold 'em and fold 'em: Chaperones and signal transduction
4. Is Fanconi anemia caused by a defect in the processing of DNA damage?
5. The ATPase core of a clathrin uncoating protein
6. Cloning of the bovine and rat Fanconi anemia group C cDNA
7. Suppression of apoptosis in hematopoietic factor-dependent progenitor cell lines by expression of the FAC gene
8. Molecular biology of Fanconi anemia: Implications for diagnosis and therapy
9. The Fanconi anaemia group G gene FANCG is identical with XRCC9
10. Isolation of a cDNA representing the Fanconi anemia complementation group E gene
11. The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM
12. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG
13. Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1
14. Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones
15. Fanconi anemia proteins FANCA, FANCC and FANCG/XRCC9 interact in a functional nuclear complex
16. The Fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex
17. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway
18. A Leu554-to-Pro substitution completely abolishes the functional complementing activity of the Fanconi anemia (FACC) protein
19. Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice
20. 2/M arrest in group C Fanconi anemia lymphoblasts reflects normal checkpoint function
21. The Fanconi anemia group C gene product is located in both the nucleus and cytoplasm of human cells
22. Hip, a novel co-chaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle
23. Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression
24. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70
25. Heat-shock proteins protect cells from monocyte cytotoxicity: Possible mechanism of self-protection
26. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases
27. Human major HSP70 protein complements the localization and functional defects of cytoplasmic mutant SV40 T antigen in Swiss 3T3 mouse fibroblast cells
28. Complementation analysis in Fanconi anemia: Assignment of the reference FA-H patient to group A
29. The Fanconi anaemia proteins, FAA and FAC, interact to form a nuclear complex
30. Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation
31. Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA
32. Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function
33. The Fanconi anemia complementation group C protein corrects DNA interstrand cross-link-specific apoptosis in HSC536N cells
34. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity
35. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis
36. Functional activity of the Fanconi anemia protein FAA requires FAC binding and nuclear localization
37. Thymine-thymine dimer bypass by yeast DNA polymerase ζ
38. 70-kDa heat-shock cognate protein colocalizes with karyophilic proteins into the nucleus during their transport in vitro
39. Tumor necrosis factor-α and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice
40. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by IFN-γ and hematopoietic growth factors
41. The role of double-stranded RNA dependent protein kinase (PKR) in mediating hypersensitivity of Fanconi anemia complementation group C cells to IFN-γ, TNF-α and double stranded RNA
42. The Fanconi anemia complementation group C (FANCC) gene product: Structural evidence of multifunctionality
43. Inactivation of the Fanconi anemia group C gene augments interferon-γ-induced apoptotic responses in hematopoietic cells
44. Interferon-γ-induced apoptotic responses of Fanconi anemia group C hematopoietic progenitor cells involve caspase 8-dependent activation of caspase 3 family members
45. Negative regulation of the Apaf-1 apoptosome by Hsp70
46. The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate
47. Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release
48. Cloning of cDNAs for Fanconi's anaemia by functional complementation
49. Positional cloning of a novel Fanconi anemia gene, FANCD2
50. Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adenoassociated virus vector
51. Overexpression of the Fanconi anemia group C gene (FAC) protects hematopoietic progenitors from death induced by Fas-mediated apoptosis
52. Identification of the peptide binding domain of hsc70. 18-Kilodalton fragment located immediately after ATPase domain is sufficient for high affinity binding
53. Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
54. Structure and expression of the human gene encoding major heat shock protein HSP70
55. Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen