Development of systemic immunity to glioblastoma multiforme using tumor cells genetically engineered to express the membrane-associated isoform of macrophage colony-stimulating factor

Journal of Immunology

Volumn 163, Issue 10, 1999, Pages 5544-5551

  Graf, Martin R ^a,b   Jadus, Martin R ^b,c   Hiserodt, John C ^b   Wepsic, H Terry ^b,c   Granger, Gale A ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOLOGY; CONTROLLED STUDY; GENE THERAPY; GLIOBLASTOMA; HOST RESISTANCE; IMMUNOREACTIVITY; IMMUNOTHERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; T LYMPHOCYTE; TUMOR REJECTION;

ANIMALS; ANTIGENS, NEOPLASM; CELL MOVEMENT; GLIOBLASTOMA; GRAFT REJECTION; IMMUNITY, NATURAL; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SUBCUTANEOUS; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MEMBRANE PROTEINS; NEOPLASM TRANSPLANTATION; PROTEIN ENGINEERING; PROTEIN ISOFORMS; RATS; RATS, INBRED F344; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0033571457     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Walker, A. E., M. Robins, and F. D. Weinfeld. 1985. Epidemiology of brain tumors: the national survey of intracranial neoplasms. Neurology 35:219.
2. Salcman, M. 1990. Malignant glioma management. Neurosurg. Clin. N. Am. 1:49.
3. Pardoll, D. M. 1993. Cancer vaccines. Immunol. Today 14:310.
4. Colombo, M. P., and G. Forni. 1994. Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now? Immunol. Today 15:48.
5. Colombo, M. P., and G. Forni. 1997. Immunotherapy. I. Cytokine gene transfer strategies. Cancer Metastasis Rev. 16:421.
6. Mackensen, A., A. Lindemann, and R. Mertelsmann. 1997. Immunostimulatory cytokines in somatic cells and gene therapy of cancer. Cytokine Growth Factor Rev. 8:119.
7. Parmiani, G., F. Arienti, J. Sule-Suso, C. Melani, M. P. Colombo, V. Ramakrishna, F. Belli, L. Mascheroni, L. Rivoltini, and N. Cascinelli. 1996. Cytokine-based gene therapy of human tumors: an overview. Folia Biol. 42:305.
8. Bubenik, J. 1996. Cytokine gene-modified vaccines in the therapy of cancer. Pharmacol. Ther. 69:1.
9. McBride, W. H., J. S. Economou, R. G. Syljuasen, C. Parrish, D. Hackman, V. Latham, C. S. Chiang, and G. J. Dougherty. 1996. The effects of cytokine gene transfer into tumors on host cell infiltration and regression. Anticancer Res. 16: 1139.
10. Pardoll, D. M. 1995. Paracrine cytokine adjuvants in cancer immunotherapy. Annu. Rev. Immunol. 13:399.
11. Ram, Z., S. Walbridge, J. D. Heiss, K. W. Culver, R. M. Blaese, and E. H. Oldfield. 1994. In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors. J. Neurosurg. 80:535.
12. Tjuvajev, J., B. Gansbacher, R. Desai, B. Beattie, M. Kaplitt, C. Matei, J. Koutcher, E. Gilboa, and R. Blasberg. 1995. RG-2 glioma growth attenuation and severe brain edema caused by local production of interleukin-2 and interferon-γ. Cancer Res. 55:1902.
13. Fakhrai, H., O. Dorigo, D. L. Shawler, H. Lin, D. Mercola, K. L. Black, I. Royston, and R. E. Sobol. 1996. Eradication of established intracranial rat gliomas by transforming growth factor β antisense gene therapy. Proc. Natl. Acad. Sci. USA 93:2909.
14. Sampson, J. H., D. M. Ashley, G. E. Archer, H. E. Fuchs, G. Dranoff, L. P. Hale, and D. D. Bigner. 1997. Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion. Neurosurgery 41: 1365.
15. Tepper, R. I., D. A. Levinson, B. Z. Stanger, J. Campos-Torres, A. K. Abbas, and P. Leder. 1990. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 62:457.
16. Yu, J. S., M. X. Wei, E. A. Chiocca, R. L. Martuza, and R. I. Tepper. 1993. Treatment of glioma by engineered interleukin 4-secreting cells. Cancer Res. 53:3125.
17. Tepper, R. I., P. K. Pattengale, and P. Leder. 1989. Murine interleukin-4 displays potent anti-tumor activity in vivo. Cell 57:503.
18. Dranoff, G., E. Jaffee, A. Lazenby, P. Golumbek, H. Levitsky, K. Brose, V. Jackson, H. Hamada, D. Pardoll, and R. C. Mulligan. 1993. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA 90:3539.
19. Fujii, S., H. Hamada, K. Fujimoto, T. Shimomura, and M. Kawakita. 1999. Activated dendritic cells from bone marrow cells of mice receiving cytokine-expressing tumor cells are associated with the enhanced survival of mice bearing syngeneic tumors. Blood 93:4328.
20. Dorsch, M., H. Hock, U. Kunzendorf, T. Diamantstein, and T. Blankenstein. 1993. Macrophage colony-stimulating factor gene transfer into tumor cells induces macrophage infiltration but not tumor suppression. Eur. J. Immunol. 23: 186.
21. Kimura, F. 1996. Augmentation of antitumor immunity using genetically M-CSF-expressing L1210 cells. Exp. Hematol. 24:360.
22. Walsh, P., A. Dorner, R. C. Duke, L. J. Su, and L. M. Glode. 1995. Macrophage colony-stimulating factor complementary DNA: a candidate for gene therapy in metastatic melanoma. J. Natl. Cancer Inst. 87:809.
23. Koch, F. 1990. Tumor necrosis factor α maintains the viability of murine epidermal Langerhans cells in culture, but in contrast to granulocyte/macrophage colony-stimulating factor, without inducing their functional maturation. J. Exp. Med. 171:159.
24. Stein, J., and C. W. Rettenmier. 1991. Proteolytic processing of a plasma membrane-bound precursor to human macrophage colony-stimulating factor (CSF-1) is accelerated by phorbol ester. Oncogene 6:601.
25. Alterman, R. L., and E. R. Stanley. 1994. Colony stimulating factor-1 expression in human glioma. Mol. Chem. Neuropathol. 21:177.
26. Stein, J., G. V. Borzillo, and C. W. Rettenmier. 1990. Direct stimulation of cells expressing receptors for macrophage colony-stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1. Blood 76:1308.
27. Jadus, M. R., M. Irwin, M. R. Irwin, R. D. Horansky, K. A. Pepper, D. B. Kohn, and H. T. Wepsic. 1996. Macrophages can recognize and kill tumor cells bearing the membrane isoform of macrophage colony stimulating factor. Blood 87:5232.
28. Jadus, M. R. 1998. Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway. J. Immunol. 160:361.
29. Rossi, M. L., J. T. Hughes, M. M. Esiri, H. B. Coakham, and D. B. Brownell. 1987. Immunohistological study of mononuclear cell infiltrate in malignant gliomas. Acta Neuropathol. (Berlin) 74:269.
30. Leenstra, S., P. K. Das, D. Troost, D. J. de Boer, and D. A. Bosch. 1995. Human malignant astrocytes express macrophage phenotype. J. Neuroimmunol. 56:17.
31. Jennings, M. T. 1991. TGF β1 and TGF β2 are potential growth regulators for low-grade and malignant gliomas in vitro: evidence in support of an autocrine hypothesis. Int. J. Cancer 49:129.
32. Tsunawaki, S. 1988. Deactivation of macrophages by transforming growth factor-β. Nature 334:260.
33. Benda, P., K. Someda, J. Messer, and W. H. Sweet. 1971. Morphological and immunochemical studies of rat glial tumors and clonal strains propagated in culture. J. Neurosurg. 34:310.
34. Liu, S. K., J. G. Jakowatz, R. B. Pollack, C. Ceraldi, R. Yamamoto, C. Dett, F. Lopez, C. Camacho, W. E. Carson, and S. M. Sentovich. 1991. Effects of intracarotid and intravenous infusion of human TNF and LT on established intracerebral rat gliomas. Lymphokine Cytokine Res. 10:189.
35. Barth, R. F. 1998. Rat brain tumor models in experimental neuro-oncology: the 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 gliomas. J. Neurooncol. 36:91.
36. Beckman, W. C. 1987. Differential retention of rhodamine 123 by avian sarcoma virus-induced glioma and normal brain tissue of the rat in vivo. Cancer 59:266.
37. Barlozzari, T., J. Leonhardt, R. H. Wiltrout, R. B. Herberman, and C. W. Reynolds. 1985. Direct evidence for the role of LGL in the inhibition of experimental tumor metastases. J. Immunol. 134:2783.
38. Testa, J. R. 1994. Spontaneous transformation of rat ovarian surface epithelial cells results in well to poorly differentiated tumors with a parallel range of cytogenetic complexity. Cancer Res. 54:2778.
39. Rose, G. S. 1996. Development and characterization of a clinically useful animal model of epithelial ovarian cancer in the Fischer 344 rat. Am. J. Obstet. Gynecol. 175:593.
40. Jadus, M. R. 1983. Functional reactivities of lymphocytes primed in murine graft-versus-host reactions. Transplantation 35:84.
41. Jadus, M. R. 1991. Effects of interleukin 4 upon human tumoricidal cells obtained from patients bearing solid tumors. J. Leukocyte Biol. 49:139.
42. Banati, R. B. 1993. Cytotoxicity of microglia. Glia 7:111.
43. Sutter, A. 1991. Antibody-mediated tumor cytotoxicity of microglia. Pathobiology 59:254.
44. Sawada, M. 1990. Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C. Brain Res. 509:119.
45. Hassan, N. F. 1991. Isolation and flow cytometric characterization of newborn mouse brain-derived microglia maintained in vitro. J. Leukocyte Biol. 50:86.
46. Ulvestad, E. 1994. Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells. J. Leukocyte Biol. 56:732.
47. McCombe, P. A. 1994. Inflammatory cells, microglia and MHC class II antigen-positive cells in the spinal cord of Lewis rats with acute and chronic relapsing experimental autoimmune encephalomyelitis. J. Neuroimmunol. 51:153.
48. Soo Hoo, W., K. A. Lundeen, J. R. Kohrumel, N.-L. Pham, S. W. Brostoff, R. M. Bartholomew, and D. J. Carlo. 1999. Tumor cell surface expression of granulocyte-macrophage colony-stimulating factor elicits antitumor immunity and protects from tumor challenge in the P815 mouse mastocytoma tumor model. J. Immunol. 162:7343.
49. Jadus, M. R., M. R. Graf, H. T. Wepsic, G. A. Granger, and J. C. Hiserodt. 1997. Development of systemic immunity to glioblastoma multiforme using tumor cells genetically engineered to express the membrane-bound isoform of macrophage-colony stimulating factor. J. Immunother. 20:419 (Abstr.).